Sickle Cell Anemia Complications
Mostrando 13-22 de 22 artigos, teses e dissertações.
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13. COMPARISON OF MAGNETIC RESONANCE IMAGING AND HISTOPATHOLOGY IN ESTIMATED HEPATIC IRON OVERLOAD IN PATIENTS WITH SICKLE CELL DISEASE. / COMPARAÇÃO ENTRE RESSONÂNCIA MAGNÉTICA E HISTOPATOLOGIA NA ESTIMATIVA DA SOBRECARGA DE FERRO HEPÁTICO EM PORTADORES DE ANEMIA FALCIFORME.
The aim of this cross-sectional study was to compare MRI with liver biopsy as a tool for identification and quantification of liver iron overload in patients with sickle cell anemia using blood transfusions. We compared the results of the baseline serum ferritin in the absence of acute complications, the estimated liver iron concentration by magnetic resonan
Publicado em: 2010
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14. Haptoglobin genotypes in sickle cell disease / Genotipos da haptoglobina nas doenças falciformes
Oxidative stress, particularly in the endothelium, exerts a strong influence on the genesis of sickle cell disease (SCD) vasoocclusion and, consequently, on patients clinical evolution and survival. The pathophysiology of SCD is centered on the polymerization property of the desoxy-hemoglobin (Hb) S, but genetic factors can act as modulators of its clinical
Publicado em: 2009
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15. Diagnóstico de hipertensão pulmonar em indivíduos adultos com doença falciforme / Diagnosis of pulmonary hypertension in adults with sickle cell disease
INTRODUCTION: Patients with sickle cell disease (SCD) and other haemolytic anaemia have increased prevalence of pulmonary hypertension (PH) that is related to higher mortality. The aim of this stdy was to determine the prevalence of PH and, its clinical, laboratorial and hemodynamic features. METHODS: In a crosssectional study, we evaluated 80 consecutive pa
Publicado em: 2008
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16. The use of genetic algorithm to calculate brain perfusion MRI maps and its application to sickle-cell disease. / O uso do algoritmo genético na construção de mapas de perfusão cerebral e sua aplicação em pacientes com anemia falciforme
Magnetic Resonance Imaging (MRI) has become a powerful clinical tool for evaluation of brain anatomy. Several recently techniques have made possible the characterization of brain function via assessment of metabolic parameters. One of these techniques is the cerebral perfusion, which describes passage of blood through the brains vascular network, and al- low
Publicado em: 2008
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17. Vivencias da gravidez relatadas por mulheres com anemia falciforme : um estudo clinico-qualitativo
As propostas de políticas de saúde para a população negra têm uma história recente no cenário político brasileiro, com um destaque especial para o Programa Nacional de Anemia Falciforme. A anemia falciforme é a doença hereditária mais comum no Brasil e constitui um problema de saúde pública. Alguns trabalhos buscaram destacar a relevância do en
Publicado em: 2007
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18. The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease
Sickle cell disease (SCD) is one of the most common inherited diseases in the world and the patients present notorious clinical heterogeneity. It is known that patients with SCD present activation of the blood coagulation and fibrinolytic systems, especially during vaso-occlusive crises, but also during the steady state of the disease. We determined if the p
Brazilian Journal of Medical and Biological Research. Publicado em: 09/08/2006
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19. Avaliação de indicadores para complicações cardiovasculares em pacientes com anemia falciforme
INTRODUCTION: Sickle cell anemia is highly associated to cardiovascular co-morbidities, contributing to a decreased life expectancy and life quality in this group. The most important risk factors for cardiovascular disease include positive family history, hypertension, hypercholesterolemia, obesity, diabetes mellitus and smoking. OBJECTIVE: To evaluate cardi
Publicado em: 2006
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20. "Um biossusceptômetro supercondutor AC para quantificar o ferro hepático". / A Superconductor AC Susceptometer to Quantify Liver Iron.
This work consisted in the development of a system to measure the magnetization of large paramagnetic and diamagnetic samples. The main application was susceptometric measurements of the hepatic tissue for quantification of the iron overload. Iron excess is commonly observed in thalassemic and sickle cell anemia patients who have repeatedly received red bloo
Publicado em: 2001
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21. In vivo blood flow abnormalities in the transgenic knockout sickle cell mouse
The accepted importance of circulatory impairment to sickle cell anemia remains to be verified by in vivo experimentation. Intravital microscopy studies of blood flow in patients are limited to circulations that can be viewed noninvasively and are restricted from deliberate perturbations of the circulation. Further knowledge of sickle blood flow abnormalitie
American Society for Clinical Investigation.
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22. A recombinant bisphosphoglycerate mutase variant with acid phosphatase homology degrades 2,3-diphosphoglycerate.
To date no definite and undisputed treatment has been found for sickle cell anemia, which is characterized by polymerization of a deoxygenated hemoglobin mutant (HbS) giving rise to deformed erythrocytes and vasoocclusive complications. Since the erythrocyte glycerate 2,3-bisphosphate (2,3-DPG) has been shown to facilitate this polymerization, one therapeuti