Sedative Hypnotic Effect
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Propofol inhibits proliferation, migration, and invasion but promotes apoptosis by regulation of Sox4 in endometrial cancer cells
Propofol is an intravenous sedative hypnotic agent of which the growth-inhibitory effect has been reported on various cancers. However, the roles of propofol in endometrial cancer (EC) remain unclear. This study aimed to explore the effects of propofol on EC in vitro and in vivo. Different concentrations of propofol were used to treat Ishikawa cells. Colony
Braz J Med Biol Res. Publicado em: 26/02/2018
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2. Neuropharmacological effects of the ethanolic extract of Sida acuta
ABSTRACT Sida acuta Burm. f., Malvaceae, is regarded as astringent, tonic and useful in treating urinary diseases and blood disorders, bile, liver and as treatment for nervous diseases. Different methods were developed: sodium pentobarbital-induced sleeping time, anxiolytic activity, test for muscle-effects, pentylenetetrazole (PTZ)-induced seizures, effect
Rev. bras. farmacogn.. Publicado em: 2016-04
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3. Chemical composition of hydroethanolic extracts from five species of the Passiflora genus
The diversified genus Passiflora is well distributed all over Brazil, and many species have been long used as medicinal plants, mainly against anxiety disturbances. This effect has been attributed to its rich flavonoid composition. Flavonoids’ main class, flavonoid glycosides, has presented central action, particularly as sedative-hypnotic, anxiolytic and
Rev. bras. farmacogn.. Publicado em: 18/09/2012
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4. Estudo comparativo dos efeitos dos Ãleos essenciais de Cymbopogon citratus e Cymbopogon winterianus (POACEAE) no sistema nervoso central de camundongos. / Comparative study of the effect of the essentials oils from Cymbopogon citratus and Cymbopogon winterianus (POACEAE) in the central nervous system of mice.
The main objective of the present work was to study in a comparative manner the effect of two essential oils, isolated from the leaves of Cymbopogon citratus (Cc) and Cymbopogon winterianus (Cw), medicinal herbs that belong to the Poaceae family and are common to the Northeast Region of Brazil. Their EOs effects were studied on the mice central nervous syste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2009
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5. Estudo da ação psicofarmacológica de Herissantia crispa (L.) Brizicky (Malvaceae)
Herissantia crispa (L.) Brizicky popularly know as malvaísco is a plant which belongs to the Malvaceae family. There arent many reports about H. crispa, however, steroids, flavonoids and glycosidic flavonoids with pharmacological activity have been isolated from this species. Other species of Malvaceae have been used in traditional medicine and many studies
Publicado em: 2009
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6. Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease
Disturbed sleep is common in chronic obstructive pulmonary disease (COPD). Conventional hypnotics worsen nocturnal hypoxemia and, in severe cases, can lead to respiratory failure. Exogenous melatonin has somnogenic properties in normal subjects and can improve sleep in several clinical conditions. This randomized, double-blind, placebo-controlled study was c
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-10
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7. Avaliação do efeito hipnótico/sedativo e ansiolítico de um extrato seco nebulizado de passiflora alata curtis (passifloraceae) / Evaluation of hypnotic/sedative and anxiolytic effects of a spray-dried extract from Passiflora alata Curtis (PASSIFLORACEAE)
O objetivo deste trabalho foi avaliar a toxicidade e ação hipnótico/sedativa e ansiolítica de um extrato seco nebulizado de Passiflora alata (PA) (2,6 % flavonóides totais), administrado pela via oral, nos testes de potenciação do sono barbitúrico, locomoção espontânea, coordenação motora, indução de catatonia, labirinto em cruz elevado, convu
Publicado em: 2007
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8. Study of Pharmacological Effects of (O-Methyl)-N-2,6-dihydroxy-benzoyl-tyramine (riparin III) from Aniba riparia (Nees) Mez (Lauraceae) on behavioral models of anxiety and depression in mice / Estudo dos efeitos farmacolÃgicos de (O-METIL)-N-2,6-Dihidroxi-benzoil Tiramina (Riparina III) de Aniba Riparia (NEES) mez (Lauraceae) em modelos comportamentais de ansiedade e depressÃo em camundongos
Riparin III, an alkamide isolated from unripe fruit of Aniba riparia, was evaluated in animal classical models for screening of new drugs in anxiety, depression, sedation and convulsion, such as, open field, rota rod, plus maze, hole board, forced swimming, tail suspension, apomorphine-induced hypothermia, pentobarbital-induced sleeping time and pentilenotet
Publicado em: 2006
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9. PARTIAL CHARACTERIZATION OF THE EFFECT OF THE ALCOHOLIC EXTRACT OF LEVES OF HYPTIS FRUTICOSA IN THE CENTRAL NERVOUS SYSTEM OF MICE / CARACTERIZAÇÃO PARCIAL DOS EFEITOS DO EXTRATO HIDROALCOÓLICO DAS FOLHAS DA Hyptis fruticosa Salzm. (ex) Benth. NO SISTEMA NERVOSO CENTRAL DE CAMUNDONGOS
O presente trabalho trata de um estudo sobre os efeitos fitoterápicos do extrato hidroalcoólico das folhas da Hyptis fruticosa. Planta típica do nordeste do Brasil utilizada como aromatizante e descongestionante, provavelmente, de Araújo e colaboradores, 1974, foram os primeiros a relatar estudo dos extratos metanólicos extraídos das raízes da planta,
Publicado em: 2006
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10. PARTIAL CHARACTERIZATION OF THE EFFECT OF THE ALCOHOLIC EXTRACT OF LEVES OF HYPTIS FRUTICOSA IN THE CENTRAL NERVOUS SYSTEM OF MICE / CARACTERIZAÇÃO PARCIAL DOS EFEITOS DO EXTRATO HIDROALCOÓLICO DAS FOLHAS DA Hyptis fruticosa Salzm. (ex) Benth. NO SISTEMA NERVOSO CENTRAL DE CAMUNDONGOS
O presente trabalho trata de um estudo sobre os efeitos fitoterápicos do extrato hidroalcoólico das folhas da Hyptis fruticosa. Planta típica do nordeste do Brasil utilizada como aromatizante e descongestionante, provavelmente, de Araújo e colaboradores, 1974, foram os primeiros a relatar estudo dos extratos metanólicos extraídos das raízes da planta,
Publicado em: 2006
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11. Efeito do diazepam na secreção salivar e na atividade metabolica da glandula submandibular de ratos
The flow of saliva plays a role in the pathogenesis of dental caries. Xerostomia induced by drugs can increase dental caries. ln this research we studied the effect of a sedative hypnotic drug (diazepan in rats salivary glands). It were used 115 rats with 21 days years old. The rats received daily injection of diazepan (0,28mg/kg) or NaCl 0,9% during 30 days
Publicado em: 1989
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12. Diazepam-induced changes in sleep: Role of the α1 GABAA receptor subtype
Ligands acting at the benzodiazepine (BZ) site of γ-aminobutyric acid type A (GABAA) receptors currently are the most widely used hypnotics. BZs such as diazepam (Dz) potentiate GABAA receptor activation. To determine the GABAA receptor subtypes that mediate the hypnotic action of Dz wild-type mice and mice that harbor Dz-insensitive α1 GABAA receptor
The National Academy of Sciences.