Sandwich Type Structure
Mostrando 13-15 de 15 artigos, teses e dissertações.
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13. Crystal structure of the membrane-exposed domain from a respiratory quinol oxidase complex with an engineered dinuclear copper center.
Cytochrome oxidase is a membrane protein complex that catalyzes reduction of molecular oxygen to water and utilizes the free energy of this reaction to generate a transmembrane proton gradient during respiration. The electron entry site in subunit II is a mixed-valence dinuclear copper center in enzymes that oxidize cytochrome c. This center has been lost du
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14. Hot-spot mutants of p53 core domain evince characteristic local structural changes
Most of the oncogenic mutations in the tumor suppressor p53 map to its DNA-binding (core) domain. It is thus a potential target in cancer therapy for rescue by drugs. To begin to understand how mutation inactivates p53 and hence to provide a structural basis for drug design, we have compared structures of wild-type and mutant p53 core domains in solution by
The National Academy of Sciences.
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15. Native topology determines force-induced unfolding pathways in globular proteins
Single-molecule manipulation techniques reveal that stretching unravels individually folded domains in the muscle protein titin and the extracellular matrix protein tenascin. These elastic proteins contain tandem repeats of folded domains with β-sandwich architecture. Herein, we propose by stretching two model sequences (S1 and S2) with four-stranded β-bar
The National Academy of Sciences.