S Nitrosothiols
Mostrando 1-12 de 48 artigos, teses e dissertações.
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1. Effects of oral administration of S-nitrosothiols and knectic evaluation of the kinetic propensity and resistance to diet induced obessity / Efeitos da administração orogástrica de s-nitrosotióis e avaliação cinética da propensão e resistência à obsidade induzida por dieta
In the present study, the nitric oxide (NO)-associated physiological actions obtained topically on the gastric mucosa and systemically in oral administrations of two NO donors-S-nitrosothiols (RSNOs), S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylcysteine (SNAC) were investigated in animal models. The topical ex vivo administration of RSNOs solutions on
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/07/2011
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2. In vitro inhibition of linoleic acid peroxidation by primary S-nitrosothiols
O óxido nítrico (•NO) é um antioxidante efetivo na inibição da peroxidação lipídica e circula in vivo principalmente como S-nitrosotióis primários (RSNOs). Neste trabalho, a peroxidação in vitro de comicelas do ácido linileico-SDS (LA-SDS) catalisada por lipoxigenase de soja (SLO) e íons FeII foi monitorada na presença e na ausência de trê
Journal of the Brazilian Chemical Society. Publicado em: 2010
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3. Preparação, caracterização morfologica e aplicações de hidrogeis de P(N-isopropilacrilamida-co-acido acrilico) / Preparation, morphological characterization of P(NIPAAM-CO-AAc) hydrogels
Hydrogels composed of polymeric networks are of great interest as biomaterials. In this work hydrogels of poly(N-isopropilacrilamide) copolimerized with acrylic acid (P(NIPAAm-co-AAc)) and cross-linked with metilene-bisacrilamide (MBAAm) at different cross-linking degrees, interpenetrated (IPNs) and semi-IPNs with PVA. The presence of AAc allowed increasing
Publicado em: 2008
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4. S-nitrosothiols effect on blocking of the lipid peroxidation / Efeito dos S-nitrosotiois no bloqueio da peroxidação lipidica
Óxido nítrico (?NO) produzido endogenamente em humanos é considerado um antioxidante efetivo na inibição da peroxidação lipídica. Todavia, no plasma e em células mamíferas, ?NO circula principalmente como S-nitrosotióis primários (RSNOs). Neste trabalho, a peroxidação in vitro de comicelas do ácido linoleico-SDS (AL-SDS) e da lipoproteína de
Publicado em: 2007
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5. Preparation, characterization and applications of nitric oxide releasing biomaterials / Preparação, caracterização e aplicações de biomateriais liberadores de oxido nitrico
O óxido nítrico (NO) está envolvido em vários processos fisiológicos como o controle do tônus vascular, a inibição da agregação plaquetária e da replicação de células musculares lisas, a resposta do sistema imune e a comunicação neuronal. Várias doenças têm sido associadas a disfunções da produção endógena de NO. Há assim, um grande
Publicado em: 2006
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6. Revestimento de stents com filmes de PVA eluidores de S-nitrosoglutationa / Stents coating with S-nitrosoglutathione-eluting poly (vynyl alcohol) films
Stents are expansible wire mesh tubes used in angioplasty procedures in order to widening the luminal diameter of the coronary arteries. There is currently a great interest in the development of stents coated with drug-eluting polymeric matrices, which are able to prevent future closure of artery (restenosis). S-nitrosothiols which are nitric oxide (NO) dono
Publicado em: 2006
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7. CHARACTERIZATION AND KINETIC STUDIES OF ALBUMIN TREATED WITH NITROGEN OXIDE DERIVED REACTIVE SPECIES: ABSORPTION SPECTROSCOPY AND FLUORESCENCE / CARACTERIZAÇÃO E ESTUDOS CINÉTICOS DE ALBUMINA TRATADA COM ESPÉCIES REATIVAS DERIVADAS DE ÓXIDOS DE NITROGÊNIO: ESPECTROSCOPIA DE ABSORÇÃO E FLUORESCÊNCIA
The discovery of the importance of nitric oxide to the human physiology expanded the investigation of mechanisms involved in the interactions of nitrogen oxide reactive species with biomolecules. S-nitrosothiols are a convenient source of nitric oxide for in vivo applications. Acid treatment with nitrite of compounds containing the SH group, including protei
Publicado em: 2005
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8. Nitric oxide release from the S-nitrosothiol zinc phthalocyanine complex by flash photolysis
The photogeneration of nitric oxide (NO) using laser flash photolysis was investigated for S-nitroso-glutathione (GSNO) and S-nitroso-N-acetylcysteine (NacySNO) at pH 6.4 (PBS/HCl) and 7.4 (PBS). Irradiation of S-nitrosothiol with light (lambda = 355 nm followed by absorption spectroscopy) resulted in the homolytic decomposition of NacySNO and GSNO to genera
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
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9. Lipid peroxidation and nitric oxide inactivation in postmenopausal women
OBJECTIVE: To assess the effect of endogenous estrogens on the bioavailability of nitric oxide (·NO) and in the formation of lipid peroxidation products in pre- and postmenopausal women. METHODS: NOx and S-nitrosothiols were determined by gaseous phase chemiluminescence, nitrotyrosine was determined by ELISA, COx (cholesterol oxides) by gas chromatography,
Arquivos Brasileiros de Cardiologia. Publicado em: 2003-04
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10. Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension
The objective of the present study was to identify disturbances of nitric oxide radical (·NO) metabolism and the formation of cholesterol oxidation products in human essential hypertension. The concentrations of·NO derivatives (nitrite, nitrate, S-nitrosothiols and nitrotyrosine), water and lipid-soluble antioxidants and cholesterol oxides were measured in
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-11
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11. Protection from Lipopolysaccharide-induced Lung Injury by Augmentation of Airway S-Nitrosothiols
Rationale: S-Nitrosothiols (SNO) inhibit immune activation of the respiratory epithelium and airway SNO levels are decreased in inflammatory lung disease. Ethyl nitrite (ENO) is a gas with chemical properties favoring SNO formation. Augmentation of airway SNO by inhaled ENO treatment may decrease lung inflammation and subsequent injury by inhibiting activati
American Thoracic Society.
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12. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
We have recently shown that nitric oxide or authentic endothelium-derived relaxing factor generated in a biologic system reacts in the presence of specific protein thiols to form S-nitrosoprotein derivatives that have endothelium-derived relaxing factor-like properties. The single free cysteine of serum albumin, Cys-34, is particularly reactive toward nitrog