Protection from Lipopolysaccharide-induced Lung Injury by Augmentation of Airway S-Nitrosothiols

AUTOR(ES)

Marshall, Harvey E.

FONTE

American Thoracic Society

RESUMO

Rationale: S-Nitrosothiols (SNO) inhibit immune activation of the respiratory epithelium and airway SNO levels are decreased in inflammatory lung disease. Ethyl nitrite (ENO) is a gas with chemical properties favoring SNO formation. Augmentation of airway SNO by inhaled ENO treatment may decrease lung inflammation and subsequent injury by inhibiting activation of the airway epithelium.

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