Rosuvastatin
Mostrando 13-24 de 26 artigos, teses e dissertações.
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13. Development and validation of a stability-indicating UPLC method for rosuvastatin and its related impurities in pharmaceutical dosage forms
The present work describes a novel stability-indicating reversed-phase ultra performance liquid chromatography method for the separation and quantification of rosuvastatin (RSV) and its related impurities in the pharmaceutical dosage forms under forced degradation conditions. An unknown degradation impurity detected in the acid degradation was identified by
Química Nova. Publicado em: 2011
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14. Suco de laranja tem efeito sinérgico à estatina e ao genfibrozila no tratamento da aterosclerose / Orange juice has a synergic effect to statin and gemfibrozil in the treat-ment of atherosclerosis
FUNDAMENTO: O suco de laranja (Citrus sinensis) é rico em vitami-na C, folatos e seu principal flavonóide, a hesperidina, cuja conformação es-pacial é semelhante à genisteína de soja que tem ação favorável sobre o aparelho cardiovascular. A vitamina C é conhecida como potente inibidor da peroxidação lipídica. Mas sua capacidade por possuir efei
Publicado em: 2010
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15. Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study
We investigated whether chronic rosuvastatin administration could improve the abnormalities of the circulating levels of vascular dysfunction markers in pulmonary arterial hypertension (PAH). Sixty patients, aged 13 to 60 years, with idiopathic (N = 14) or congenital heart disease-associated PAH (N = 46) were equally but randomly assigned to rosuvastatin tre
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-08
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16. Estatinas hipolipêmicas e novas tendências terapêuticas
Statins are the most used drugs for the treatment of hyperlipidemia in primary and secondary prevention, with the aim of decreasing the levels of plasmatic cholesterol- lipoproteins. Owing to their structural similarity to the substrate HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), they inhibit the HMG-CoA reductase enzyme, disrupting the cholesterol biosynthesi
Química Nova. Publicado em: 2007-04
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17. Comparative study on effects of rosuvastatin and atrovastatin in plasmatic lipidids, lipidic peroxidation, tissuel cholesterol and endothelium disfunction in hypercholesterolemic rabbits / Estudo comparativo dos efeitos da rosuvastatina e atorvastatina nos lipides plasmaticos, peroxidação lipidica e função endotelial em coelhos hipercolesterolemicos
Objective: The aim of this study was to detect the effect of the rosuvastatin on plasmatic lipids, lipidic peroxidation, tis sueI cholesterol, and endothelium disfunction and to compare its effect with the atorvastatin in hypercholesterolemic rabbits. Methods: Forty male New Zealand white rabbits were randomized in Four Groups: Group Hypercholesterolemic (GH
Publicado em: 2007
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18. Estimation of rosuvastatin in human plasma by HLPC tandem mass spectroscopic method and its application to bioequivalence study
Um método empregando LC-MS/MS foi desenvolvido para a análise de rosuvastatina em plasma humano, usando atorvastatina como padrão interno. Rosuvastatina é um fármaco para redução de lipídeos e prescrita para o tratamento do hipercolesterolemia e de dislipidimia. A extração em fase sólida (SPE) foi usada para purificação e pré-concentração do
Journal of the Brazilian Chemical Society. Publicado em: 2005-10
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19. Rosuvastatin 20 mg restores normal HDL-apoA-I kinetics in type 2 diabetes
Catabolism of HDL particles is accelerated in type 2 diabetes, leading to a reduction in plasma residence time, which may be detrimental. Rosuvastatin is the most powerful statin to reduce LDL-cholesterol, but its effects on HDL metabolism in type 2 diabetes remain unknown. We performed a randomized double-blind cross-over trial of 6-week treatment period wi
American Society for Biochemistry and Molecular Biology.
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20. Effects of rosuvastatin on electronegative LDL as characterized by capillary isotachophoresis: the ROSARY Study
Electronegative LDL, a charge-modified LDL (cm-LDL) subfraction that is more negatively charged than normal LDL, has been shown to be inflammatory. We previously showed that pravastatin and simvastatin reduced the electronegative LDL subfraction, fast-migrating LDL (fLDL), as analyzed by capillary isotachophoresis (cITP). The present study examined the effec
The American Society for Biochemistry and Molecular Biology.
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21. Rosuvastatin (Crestor) and rhabdomyolysis
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22. Rosuvastatin doesn't work for older people with ischaemic heart failure
BMJ Publishing Group Ltd..
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23. No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin
Blackwell Science Inc.
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24. Effects of Rosuvastatin and Atorvastatin on LDL and HDL Particle Concentrations in Patients With Metabolic Syndrome: A randomized, double-blind, controlled study
American Diabetes Association.