Rosiglitazone
Mostrando 13-24 de 64 artigos, teses e dissertações.
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13. Rosiglitazone may induce renal injury in normal rats but not in hypercholesterolemic rats / Rosiglitazone pode causar lesão tubular renal em ratos normais mas não em ratos hipercolesterolêmicos
Introdução: Rosiglitazone (RGL) é um ligante dos receptores PPAR e vem sendo usada no tratamento do Diabetes Mellitus tipo 2 e nas doenças inflamatórias. Mas, RGL pode reduzir a filtração glomerular (FG), a carga excretada de sódio na urina (UVNa) e aumentar a expressão da Na+,K+- ATPase na medula renal. Então, RGL pode causar edema e insuficiênci
Publicado em: 2009
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14. Relação entre a Síndrome Metabólica, teor de gordura intramiocelular e os níveis plasmáticos da Adiponectina: papel da Rosiglitazona / Relationship between the Metabolic Syndrome, intramyocellular fat and plasma Adiponectin: role of Rosiglitazone
Insulin resistance (IR) is associated with intramyocellular lipid (IMCL) content and low serum adiponectin (ADP) levels. ADP is also involved in muscle fat oxidation but the relationship between them is still controversial. We aimed to further explore the relationship between ADP and IMCL content in non-diabetic adults and the role of rosiglitazone (RSG) in
Publicado em: 2009
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15. Rosiglitazona, agonista do PPAR-y "Peroxisome Proliferator-Activated Receptor-y" reverte a nefrotoxicidade induzida pelo tenofovir-DF / The peroxisome proliferator-activated receptor-y agonist rosiglitazone reverses tenofovir-induced nephrotoxicity
Objective: To characterize the mechanisms of tenofovir disoproxil fumarate (TDF)- induced nephrotoxicity and the protective effects of rosiglitazone (RSG), a peroxisome proliferator-activated receptor-y agonist. Methods: Rats were treated for 30 days with one of two TDF doses (50 or 300 mg/kg of food), to which RSG (92 mg/kg of food) was added for the last 1
Publicado em: 2008
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16. Síntese e avaliação farmacológica de derivados fenóxi-acetoacetatos em receptores ativadados por proliferadores peroxissomais e em receptores de hormônio tireoideano
Nuclear receptors (NRs) are of great importance for the worldwide drug market since they are involved in mechanisms which influence several diseases that affect humanity like, for instance, diabetes mellitus (DM2), obesity, dislypemia and atherosclerosis. Peroxisome Proliferator-Activated Receptors (PPAR) and Thyroid Hormone Receptors (TR) control important
Publicado em: 2008
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17. Vitamin E: characterization of the biological activity and relation with the nuclear receptor PPARy. / Vitamina E: caracterização da atividade biológica na resposta inflamatória induzida pelo LPS e sua relação com o receptor nuclear PPARy.
Vitamin E, a generic term to describe a group of structurally lipophilic molecules (tocopherols and tocotrienols), is one of the most known antioxidants and it has been studied also because its non-antioxidant roles. By the way, depending on the administered dose, -tocopherol can exert antagonic effects in vitro. Its known that PPAR, a nuclea
Publicado em: 2007
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18. Efeito da rosiglitazona e da lovastatina na resistencia insulinica da dieta hiperlipidica / Effects of rosiglitazone and lovastatin in insulin resistance of high-fat fed rats
A insulina é o principal hormônio anabólico, que atua através da ativação de transportadores, regulação de enzimas e expressão de genes que codificam enzimas envolvidas na captação e armazenamento de substratos. Para exercer suas ações, a insulina emprega duas vias principais de sinalização intracelular: a via da PI 3-quinase e a via da MAPK.
Publicado em: 2007
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19. Efeitos da rosiglitazona sobre marcadores de risco cardiovascular e função da celula beta em diabeticos tipo 2 virgens de tratamento / Rosiglitazone effects on cardiovascular risk markers and beta cell function in drug naive type 2 diabetic patients
A principal causa de mortalidade entre os portadores de Diabetes tipo 2 é a doença cardiovascular. Estudos têm cada vez mais procurado alterações inerentes ao diabetes tipo 2 que justifiquem a maior incidência de doença cardiovascular nesse grupo. A presença de resistência à insulina, redução de adiponectina, aumento de PCR, disfunção endotelia
Publicado em: 2007
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20. SÃntese, modelagem molecular e atividade hipoglicemiante de novas arilideno-tiazolidinadionas
The glitazones, also referred to as insulin sensitizers, are generically a class of thiazolidinediones (TZDs) that possess hypoglycemic activity and are orally administered in patients with type II diabetes mellitus. Two of these thiazolidinediones are rosiglitazone and pioglityazone. We synthesized 12 arylideno-thiazolidinediones (ATZDs) of 5-benzylideno-3-
Publicado em: 2006
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21. Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature
Oxidative stress contributes to cardiovascular complications of diabetes, in part, by reducing the bioavailability of nitric oxide (NO). We investigated the mechanisms whereby the insulin sensitizer rosiglitazone may ameliorate oxidative stress in the vasculature of spontaneously hypertensive rats (SHR). Nine-week-old SHR were treated by gavage for 7 wk with
American Physiological Society.
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22. Peroxisome Proliferator-activated Receptor γ Agonist Rosiglitazone Increases Expression of Very Low Density Lipoprotein Receptor Gene in Adipocytes*♦
Apolipoprotein E (apoE) and its receptor, very low density lipoprotein receptor (VLDLR), are involved in fat accumulation in adipocytes. Here, we investigated the effect of a peroxisome proliferator-activated receptor (PPAR) γ agonist, rosiglitazone, on regulation of VLDLR expression both in white adipose tissue (WAT) of obese mice and in cultured adipocyte
American Society for Biochemistry and Molecular Biology.
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23. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
Adipose tissue plays a central role in the control of energy homeostasis through the storage and turnover of triglycerides and through the secretion of factors that affect satiety and fuel utilization. Agents that enhance insulin sensitivity, such as rosiglitazone, appear to exert their therapeutic effect through adipose tissue, but the precise mechanisms of
American Society for Clinical Investigation.
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24. Rosiglitazone Is Associated with Mortality in Chronic Hemodialysis Patients
Recent studies have associated rosiglitazone, a thiazolidinedione drug, with adverse cardiovascular outcomes in the general population with diabetes. Using data from the Dialysis Outcomes and Practice Patterns Study in the United States, we examined cardiovascular hospitalization and mortality associated with prescription of rosiglitazone, compared with othe
American Society of Nephrology.