Rna Stability
Mostrando 13-24 de 2023 artigos, teses e dissertações.
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13. Platelets can be a biological compartment for the Hepatitis C Virus
Although HCV has hepatic tropism, the presence of the virus in extra-hepatic compartments has been well documented. Platelets have been described as carriers of the virus in the circulation and may be a natural reservoir for the virus. However, few studies have been performed to evaluate the levels of HCV RNA in plasma and platelets are equal or differ in so
Braz. J. Microbiol.. Publicado em: 2015-06
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14. NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) me
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-11
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15. Characterization of Bacteriocin like inhibitory substance produced by a new Strain Brevibacillus borstelensis AG1 Isolated from 'Marcha'
In the present study, a bacterium isolated from Marcha- a herbal cake used as traditional starter culture to ferment local wine in North East India, was evaluated for bacteriocin like inhibitory substance production and was tested against six food borne/spoilage causing pathogens viz. Listeria monocytogenes MTCC 839, Bacillus subtilis MTCC 121, Clostridium p
Braz. J. Microbiol.. Publicado em: 2014-09
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16. Target-directed catalytic metallodrugs
Most drugs function by binding reversibly to specific biological targets, and therapeutic effects generally require saturation of these targets. One means of decreasing required drug concentrations is incorporation of reactive metal centers that elicit irreversible modification of targets. A common approach has been the design of artificial proteases/nucleas
Braz J Med Biol Res. Publicado em: 02/07/2013
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17. Imunoproteção de ilhotas pancreáticas microencapsuladas em biomateriais inovadores e seu potencial terapêutico no diabetes mellitus tipo 1 / Immunoprotection of pancreatic islets microencapsulated in inovative biomaterials and its therapeutic potential in type 1 Diabetes Mellitus
Transplantation of microencapsulated islets represents an attractive therapeutical approach to treat type 1 Diabetes Mellitus, accounting for an improved glycemic control and the abolishment of immunosuppressive therapies. However, maintenance of long-term β-cell viability remains a major problem. During islet isolation, the loss of extracellular matrix
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/05/2012
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18. Biogênese, estabilidade e localização sub-celular de RNAs não-codificadores longos expressos em regiões intrônicas do genoma humano / Biogenesis, stability and sub-cellular localization of long non-coding RNAs expressed in intronic regions of the human genome
Trabalhos recentes indicam que a maior parte do transcriptoma de células de mamíferos é composto por RNAs não-codificadores de proteínas (ncRNAs). Nosso grupo tem identificado e caracterizado ncRNAs longos (>200 nt), sem splicing, expressos em regiões intrônicas de genes codificadores de proteína. Contudo, a biogênese, processamento e localização
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/03/2012
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19. Screening and isolation of halophilic bacteria producing industrially important enzymes
Halophiles are excellent sources of enzymes that are not only salt stable but also can withstand and carry out reactions efficiently under extreme conditions. The aim of the study was to isolate and study the diversity among halophilic bacteria producing enzymes of industrial value. Screening of halophiles from various saline habitats of India led to isolati
Braz. J. Microbiol.. Publicado em: 2012-12
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20. The zinc finger protein TcZFP2 binds target mRNAs enriched during Trypanosoma cruzi metacyclogenesis
Trypanosomes are parasitic protozoa in which gene expression is primarily controlled through the regulation of mRNA stability and translation. This post-transcriptional control is mediated by various families of RNA-binding proteins, including those with zinc finger CCCH motifs. CCCH zinc finger proteins have been shown to be essential to differentiation eve
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-09
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21. Influência da integridade dos barorreceptores nos ajustes morfofuncionais cardíacos à hipertensão espontânea em ratos / Influence of baroreceptor integrity on cardiac morpho-functional adjustments to spontaneous hypertension in rats
It has been demonstrated that reduced baroreflex sensitivity is an independent marker of mortality risk. The arterial baroreflex plays an important role in the maintenance of the moment-to-moment stability of blood pressure (BP). Although the contribution of blood pressure variability (BPV) to cardiovascular morbidity and mortality is well established, the m
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/07/2011
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22. Hypothyroidism decreases proinsulin gene expression and the attachment of its mRNA and eEF1A protein to the actin cytoskeleton of INS-1E cells
The actions of thyroid hormone (TH) on pancreatic beta cells have not been thoroughly explored, with current knowledge being limited to the modulation of insulin secretion in response to glucose, and beta cell viability by regulation of pro-mitotic and pro-apoptotic factors. Therefore, the effects of TH on proinsulin gene expression are not known. This led u
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-10
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23. Mechanisms and role of microRNA deregulation in cancer onset and progression
MicroRNAs are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20-23 nucleotide (nt) length that control gene expression in many cellular processes. These molecules typ
Genetics and Molecular Biology. Publicado em: 2011
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24. Identification of reference genes for expression analysis by real-time quantitative PCR in drought-stressed soybean.
Abstract ? The objective of this work was to validate, by quantitative PCR in real time (RT-qPCR), genes to be used as reference in studies of gene expression in soybean in drought-stressed trials. Four genes commonly used in soybean were evaluated: GmB-actin, GmGAPDH, GmLectin and GmRNAr18S. Total RNA was extracted from six samples: three from roots in a hy
Pesquisa Agropecuária Brasileira. Publicado em: 2011