Rmd
Mostrando 13-24 de 26 artigos, teses e dissertações.
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13. Fludarabine induces apoptosis in chronic lymphocytic leukemia - the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins
The expression of P53, Bcl-2, Bax, Bag-1, and Mcl-1 proteins in CD5/CD20-positive B-chronic lymphocytic leukemia (B-CLL) cells from 30 typical CLL patients was evaluated before and after 48 h of incubation with 10-6 M fludarabine using multiparametric flow cytometric analysis. Protein expression was correlated with annexin V expression, Rai modified clinical
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-03
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14. Projeto e implementação do controle de posição de uma antena de radar meteorológico através de servomecanismos. / Design and implementation of a weather-radar antenna position control using servomechanisms.
A classical radar antenna is basically composed of a primary source mounted at the focal point of a parabolic reflector. The illumination rule is established so that the desired beam-shape is attained, as precisely as possible. The physical motion of the set guarantees the coverage of the desired volume of exploitation. The actual text studies the design and
Publicado em: 2006
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15. Avaliação da densidade mineral ossea na espondilite anquilosante
Bone mineral density (BMD) of lumbar spine and femoral neck was measured in 42 male patients with Ankylosing Spondylitis (AS) by dual-energy X-ray absoptiometry (DEXA). Patient?s mean age was 36 years, mean age at onset was 23,4 years and mean disease duration was 12,6 years. HLA-B27 was positive in 76,2% of patients. All patients underwent clinical and radi
Publicado em: 1998
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16. Sintese de oligomeros acrilados de uretana e estudo da degradação termica de resinas fotocuraveis por ultravioleta a base desses oligomeros
The urethane acrylate oligomers are utilized in the formulation of radiation curable coatings for optical fibers. In this work were synthesized two types of the urethane acrylate oligomers with the purpose to develop coating with long "useful" lifetime and to evaluate the thermal degradation process of cured films based on this oligomers. These resins are UV
Publicado em: 1992
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17. Expansion of a Unique Region in the Marek's Disease Virus Genome Occurs Concomitantly with Attenuation but Is Not Sufficient To Cause Attenuation
Pathogenic Marek's disease viruses (MDVs) have two head-to-tail copies of a 132-bp repeat. As MDV is serially passaged in cell culture, the virus becomes attenuated and the number of copies of the 132-bp repeat increases from 2 to often more than 20 copies. To determine the role of the repeats in attenuation, we used five overlapping cosmid clones that spann
American Society for Microbiology.
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18. Marek's Disease Virus-Encoded vIL-8 Gene Is Involved in Early Cytolytic Infection but Dispensable for Establishment of Latency
Marek's disease, a lymphoproliferative disease of chickens, is caused by an alphaherpesvirus, Marek's disease virus (MDV). This virus encodes a virokine, vIL-8, with general homology to cellular CXC chemokines such as interleukin-8 (IL-8) and Gro-α. To study the function of vIL-8 gene, we deleted both copies of vIL-8 residing in the terminal repeat long and
American Society for Microbiology.
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19. Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication
Marek's disease virus (MDV) causes an acute lymphoproliferative disease in chickens, resulting in T cell lymphomas in visceral organs and peripheral nerves. Earlier studies have determined that the repeat regions of oncogenic serotype 1 MDV encode a basic leucine zipper protein, Meq, which structurally resembles the Jun/Fos family of transcriptional activato
National Academy of Sciences.
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20. Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis.
Structures of insulin in different crystal forms exhibit significant local and nonlocal differences, including correlated displacement of elements of secondary structure. Here we describe the solution structure and dynamics of a monomeric insulin analogue, des-pentapeptide-(B26-B30)-insulin (DPI), as determined by two-dimensional NMR spectroscopy and distanc
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21. Pharmacokinetics, Safety, and Tolerability of Oral Posaconazole Administered in Single and Multiple Doses in Healthy Adults
The pharmacokinetics, safety, and tolerability of posaconazole, an investigational triazole antifungal, were evaluated following the administration of rising single and multiple oral doses. A total of 103 healthy adults were enrolled in two phase I trials. Each study had a double-blind, placebo-controlled, parallel-group design with a rising single-dose (RSD
American Society for Microbiology.
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22. Rescue of a pathogenic Marek's disease virus with overlapping cosmid DNAs: Use of a pp38 mutant to validate the technology for the study of gene function
Marek's disease virus (MDV) genetics has lagged behind that of other herpesviruses because of the lack of tools for the introduction of site-specific mutations into the genome of highly cell-associated oncogenic strains. Overlapping cosmid clones have been successfully used for the introduction of mutations in other highly cell-associated herpesviruses. Here
The National Academy of Sciences.
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23. The effect of visual training for patients with visual field defects due to brain damage: a systematic review
The objective of this review was to evaluate whether systematic visual training leads to (1) a restitution of the visual field (restoration), (2) an increase in the visual search field size or an improvement in scanning strategies (compensation) and (3) a transfer of training‐related improvements in activities of daily living such as reading. To retrieve r
BMJ Group.
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24. Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)2
The solution structure of the dodecamer duplex d(CTTTTGCAAAAG)2 and its 2:1 complex with the bis-benzimidazole Hoechst 33258 has been investigated by NMR and NOE-restrained molecular dynamics (rMD) simulations. Drug molecules are bound in each of the two A-tracts with the bulky N-methylpiperazine ring of each drug located close to the central TG (CA) step, b
Oxford University Press.