Rhodopsin
Mostrando 1-12 de 401 artigos, teses e dissertações.
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1. Genetic analysis reveals candidate species in the Scinax catharinae clade (Amphibia: Anura) from Central Brazil
Abstract Scinax (Anura: Hylidae) is a species-rich genus of amphibians (113 spp.), divided into five species groups by morphological features. Cladistic analyses however revealed only two monophyletic clades in these groups: Scinax catharinae and Scinax ruber. Most species from the S. catharinae clade are found in Atlantic rainforest, except for Scinax canas
Genet. Mol. Biol.. Publicado em: 2016-03
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2. Estudo in vitro do potencial de diferenciação das células tronco imaturas da polpa dentária humana em neurônios retinais. / Study of in vitro differentiation of human immature dental pulp stem cells into retinal neurons cells.
A retina é composta por células neuronais especializadas, que quando danificadas são incapazes de se regenerar. CTIPD são uma promissória fonte para substituir o tecido lesado pois são capazes de se diferenciar em quase todos os tipos celulares. O objetivo do estudo é avaliar o potencial de diferenciação das CTIPD em neurônios retinais. As CTIPD fo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/10/2012
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3. Efeito de α-MSH sobre a expressão gênica de rodopsina, tirosinase e do receptor de α-MSH, subtipo MC1R, em melanócito B16 de Mus musculus / α-MSH effects on rhodopsin, tyrosinase and MC1R genes in B16 Mus musculus melanocytes
A coloração dos vertebrados deve-se a presença de pigmentos, sintetizados e/ou armazenados em células denominadas células pigmentares cutâneas. A mudança de cor nos vertebrados é principalmente regulada por α-MSH e uma família de enzimas melanossômicas, que incluem tirosinase e as proteínas relacionadas à tirosinase 1 e 2 (TRP-1 e TRP-2, re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/09/2012
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4. Finding new approaches to treat retinitis pigmentosa caused by mutations in the photoreceptor rhodopsin. / Em busca de novos métodos de tratamento para a retinose pigmentar causada por mutações na rodopsina.
Retinitis Pigmentosa (RP) is an inherited disease that progressively leads to blindness. More than 150 mutations associated with RP are known in rhodopsin, causing its misfolding. This thesis tested the hypothesis that small molecules can rescue folded rhodopsin and/or reduce photoreceptor cell death. RP mutations, N15S and P23H, revealed differences in char
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/07/2012
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5. Modulation of rhodopsin gene expression and signaling mechanisms evoked by endothelins in goldfish and murine pigment cell lines
Endothelins (ETs) and sarafotoxins (SRTXs) belong to a family of vasoconstrictor peptides, which regulate pigment migration and/or production in vertebrate pigment cells. The teleost Carassius auratus erythrophoroma cell line, GEM-81, and Mus musculus B16 melanocytes express rhodopsin, as well as the ET receptors, ETB and ETA, respectively. Both cell lines a
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-09
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6. Expressão gênica e protéica de rodopsina em células pigmentares e mecanismos de sinalização intracelular da sua modulação por endotelinas / Modulation of rhodopsin expression and signaling mechanisms evoked by endothelins in in pigment cell lines
Endothelins (ETs) and sarafotoxins (SRTXs) belong to a family of vasoconstrictor peptides, which can regulate pigment migration and/or production in vertebrate pigment cells (chromatophores). In teleostean fish, ETs/SRTXs induce pigment migration. In human melanocytes, ETs promote melanogenesis and mitogenesis. ETs also regulate the transcription of several
Publicado em: 2009
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7. Estudo da modelagem molecular do receptor canabinóide CB1 e suas interações com o ∆9 - THC / Molecular modeling study of CB1 cannabinoid receptor and its interaction with delta-9-THC
Marijuana (Cannabis sativa) is a widely used plant and its various applications have important benefits. The plant Cannabis sativa has been used by man for centuries for eating, medicinal practices and religious rituals. In human subjects, its effects include analgesia, alterations in perceptions, cognition, memory and psychomotor activity. The cannabinoid c
Publicado em: 2009
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8. Estudo citogenetico e das relações filogeneticas de Engystomops petersi e Engystomops sp. (Anura, Leiuperidae) / Cytogenetics and phylogenetics studies of Engystomops petersi and Engystomops sp. (Anura, Leiuperidae)
The frog Engystomops petersi is widely distributed in the Amazon basin. Genetic divergence and speciation mechanisms of E. petersi populations have been inferred mainly from mitochondria DNA (mtDNA) and microsatellite polymorphisms, male advertisement call and sexual selection. In spite of the significant progress resulting from these studies, many cytogenet
Publicado em: 2009
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9. Pupil size following dark adaptation in patients with retinitis pigmentosa
According to the equivalent light hypothesis, molecular defects in the photoreceptor lead to a continuous activation of the photoreceptor cascade in a manner equivalent to real light. The consequences in diseases such as retinitis pigmentosa (RP) are as disruptive to the cells as real light. Two forms of the equivalent light hypothesis can be distinguished:
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-08
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10. Structure and function in rhodopsin: Asymmetric reconstitution of rhodopsin in liposomes
We report on preparation of rhodopsin proteoliposomes with the cytoplasmic domain of rhodopsin facing the exterior of the proteoliposomes. Rhodopsin purified from rod outer segments of bovine retinae by immunoaffinity chromatography in octyl glucoside was reconstituted into liposomes prepared from soybean phospholipids by detergent dialysis. The orientation
The National Academy of Sciences.
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11. Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.
We report here the high-level expression of a synthetic gene for bovine rhodopsin in transfected monkey kidney COS-1 cells. Rhodopsin is produced in these cells to a level of 0.3% of the cell protein, and it binds exogenously added 11-cis-retinal to generate the characteristic rhodopsin absorption spectrum. We describe a one-step immunoaffinity procedure for
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12. Structure and function in rhodopsin: covalent crosslinking of the rhodopsin (metarhodopsin II)-transducin complex--the rhodopsin cytoplasmic face links to the transducin alpha subunit.
We prepared rhodopsin mutants that contained a single reactive cysteine residue per rhodopsin molecule at position 65, 140, 240, or 316 on the cytoplasmic face. A carbene-generating photoactivatable group was linked by a disulfide bond to the cysteine sulfhydryl group of each of the rhodopsin mutants. The resulting derivative was then light-activated at lamb