Rhbmp 2
Mostrando 13-24 de 24 artigos, teses e dissertações.
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13. Cultivo de células da medula óssea humana sobre membranas de colágeno bovino e arcabouços de ácido poliglicóico polilático (PLGA)
O estroma da medula óssea, além de conter uma população heterogênea de células conjuntivas, nervosas e hematopoiéticas, mantém uma quantidade de células com características de células tronco (células mesenquimais indiferenciadas). Estas possuem capacidade de se diferenciarem em qualquer célula de natureza conjuntiva quando estimuladas pelo organ
Publicado em: 2007
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14. Influência de diferentes superfícies de titânio na adesão, proliferação e diferenciação de células semelhantes a osteoblastos em culturas, na presença ou não de proteína morfogenética óssea-7 (BMP-7) / Influence of different titanium surface on the adhesion, proliferation and differentiation of osteoblast-like cells cultured in the presence or absence of bone morphogenetic protein-7 (BMP-7)
O objetivo deste trabalho foi avaliar a influência das características química e de rugosidade da superfície de titânio sobre a adesão, proliferação e diferenciação de células semelhantes aos osteoblastos de rato (Osteo-1), cultivados em meio de cultura adicionado de BMP-7. MATERIAL E MÉTODO: Células Osteo-1 foram cultivadas sobre discos de tit�
Publicado em: 2007
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15. Estudo imunoistoquimico da incorporação de enxerto alogeno com proteina morfogenetica do osso-2 na mandibula de rato
Large bone defects can be managed by autogenous graft; however limitations in this source have induced research for new materials to replace autogenous graft. The incorporation of autoclaved alogenous bone graft associated to recombinant human bone morphogenetic protein 2 (rhBMP-2) was the objective of this study. The study animals were 75 Wistar rats distri
Publicado em: 2004
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16. rhBMP-2 Modulation of Gene Expression in Infected Segmental Bone Defects
The osteoinductive capability of BMPs appears diminished in the setting of acute infection. We applied rhBMP-2 to a segmental defect in a rat femur and measured the expression of key bone formation genes in the presence of acute infection. Types I and II collagen, osteocalcin, and BMP Type II receptor mRNA expression were characterized in 72 Sprague-Dawley r
Springer-Verlag.
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17. Can rhBMP-2 Containing Collagen Sponges Enhance Bone Repair in Ovariectomized Rats?: A Preliminary Study
With an aging population the frequency of postmenopausal fractures is increasing. Methods to enhance the repair of osteoporotic bone repair therefore become more important to reduce the society burden of care. We asked if absorbable collagen sponges containing recombinant human bone morphogenetic protein-2 (rhBMP-2) have the potential to enhance bone repair.
Springer-Verlag.
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18. Effect of a freeze-dried CMC/PLGA microsphere matrix of rhBMP-2 on bone healing
The hypothesis of this research was that implants of poly(lactide-co-glycolide) (PLGA) microspheres loaded with bone morphogenetic protein-2 (rhBMP-2) and distributed in a freeze-dried carboxymethylcellulose (CMC) matrix would produce more new bone than would matrix implants of non-protein-loaded microspheres or matrix implants of only CMC. To test this hypo
Springer-Verlag.
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19. Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15
Oocyte-derived growth factors are critically involved in multiple ovarian processes via paracrine actions. Although recombinant proteins have been applied to dissect the physiological functions of these factors, variation of activities among different protein preparations remains an issue. To further elucidate the roles of one of these growth factors, bone m
Oxford University Press.
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20. Porous bone morphogenetic protein-2 microspheres: Polymer binding and in vitro release
This research compared the binding and release of recombinant human bone morphogenetic protein 2 (rhBMP-2) with a series of hydrophobic and hydrophilic poly-lactide-co-glycolide (PLGA) copolymers. Porous microspheres were produced via a double emulsion process. Binding and incorporation of protein were achieved by soaking microspheres in buffered protein sol
Springer-Verlag.
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21. Correlation of Computed Tomography with Histology in the Assessment of Periprosthetic Defect Healing
Computed tomography (CT) may more accurately assess the healing of grafted osteolytic lesions around acetabular components compared with plain radiographs, although clinical validation is lacking. To determine whether clinical or micro-CT imaging could assess accurately the grafted lesion compared with histology, we therefore quantified bone healing and ingr
Springer-Verlag.
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22. Stimulation of Ectopic Bone Formation in Response to BMP-2 by Rho Kinase Inhibitor: A Pilot Study
The small GTPase Rho and Rho-associated protein kinase (Rho kinase, ROCK) signal participates in a variety of biological functions including vascular contraction, tumor invasion, and penile erection. Evidence also suggests Rho-ROCK is involved in signaling for mesenchymal cellular differentiation. However, whether it is involved in osteoblastic differentiati
Springer-Verlag.
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23. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression.
Subcutaneous implantation of demineralized bone matrix initiates a sequence of developmental events, which culminate in endochondral bone formation. During early stages of development of matrix-induced implants, ED1, Ia-positive monocytes-macrophages were observed, suggesting that in the initial phases of the endochondral bone formation cascade, the bone-ind
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24. Successful Spinal Fusion by E. coli-derived BMP-2-adsorbed Porous β-TCP Granules: A Pilot Study
Bone morphogenetic proteins (BMPs) were originally identified as osteoinductive proteins. With cloning of BMP genes, studies of BMPs and their clinical application have advanced. However, with increasing clinical applications, drug delivery systems and production costs have become more important issues. To address these issues, we asked whether E. coli-deriv
Springer-Verlag.