Release Of Drug
Mostrando 13-24 de 843 artigos, teses e dissertações.
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13. Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats
Abstract Objective: To investigate the use of polymethyl methacrylate (PMMA) electrospun fiber mats containing different amounts of polyethylene oxide (PEO) as a doxycycline delivery system and to test antibacterial activity against an oral pathogen. Methodology: PMMA powders or PEO (mol wt 200 Kd) (10,20,30% w/w/) were dissolved in N, N-dimethylformamide
J. Appl. Oral Sci.. Publicado em: 07/10/2019
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14. Preparation and evaluation of 2-methoxyestradiol-loaded pH-sensitive liposomes
The development and clinical application of 2-methoxyestradiol (2-ME) as a new type of antitumor drug are limited due to its poor solubility, rapid metabolism in vivo, and large oral dosage. 2-ME-loaded pH-sensitive liposomes (2-ME-PSLs) was prepared containing the lipids, Lipoid E-80 (E-80), cholesteryl hemisuccinate (CHEMS), and cholesterol (CHOL) via thin
Braz. J. Pharm. Sci.. Publicado em: 03/10/2019
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15. Effectiveness of a low-dose Norgestomet ear implant in short-term protocols to induce estrus in ewes during the non-breeding season in Brazil.
ABSTRACT The objective of this study was to evaluate the reproductive performance of ewes subjected to a short-term protocol for estrus induction using 1 mg of Norgestomet during the non-breeding season in Brazil. A total of 84 ewes were randomly divided into two equal groups (n = 42 per group). Controlled Internal Drug Release (CIDR) containing 330 mg proge
R. Bras. Zootec.. Publicado em: 03/10/2019
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16. Study of erythrocytes as a novel drug carrier for the delivery of artemether
Resealed erythrocytes have been explored in various dimensions of drug delivery, owing to their high biocompatibility and inability to initiate immune response. The present research was designed to evaluate the drug delivery potential of erythrocytes by loading a hydrophobic anti-malarial drug, Artemether. Three different loading techniques were applied to a
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
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17. CONTROLLED RELEASE OF THEOPHYLLINE-CHITOSAN COMPOSITE PARTICLES PREPARED USING SUPERCRITICAL ASSISTED ATOMIZATION
Abstract This study investigated the formation of composite particles of chitosan (CS) and theophylline (TPH) via supercritical assisted atomization (SAA) using aqueous ethanol (50%, v/v) as the solvent and supercritical CO2 as the spraying medium. According to XRD, DSC, and FTIR analyses, the crystal form of the SAA-treated TPH from the as-received TPH was
Braz. J. Chem. Eng.. Publicado em: 30/09/2019
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18. HYDROXYAPATITE - CARBON NANOTUBE COMPOSITES FOR DRUG DELIVERY APPLICATIONS
Abstract The aim of this study was the synthesis of composites containing hydroxyapatite (Hap) or silicon substituted hydroxyapatite (HapSi), carboxyl functionalized carbon nanotubes (fMWCNT) and gelatin (G) in different ratios. Ibuprofen (IBU) was chosen as a model drug for the formulation of extended-release dosage forms. The obtained composites were chara
Braz. J. Chem. Eng.. Publicado em: 30/09/2019
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19. Mass Variation Rate, in Acidic Environment, of Polyhydroxybutyrate and Chitosan matrices with Potential Application as Controlled Drug Delivery System
Polymers such as the biocompatible polyhydroxybutyrate (PHB) and the polysaccharide chitosan (Chi), a pH-sensitive polymer, have been studied for drug delivery applications and scaffolds production. In this work, matrices of PHB and Chi were produced by compression molding (SPHB-Chi) and loaded with a broad-spectrum biocide chlorhexidine (CHX) (SPHB-Chi-CHX)
Mat. Res.. Publicado em: 30/09/2019
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20. Development and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy
Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines. However, anatomy of the eye and its natural protective mechanisms create challenges for ocular drug delivery. Rapid elimination of antihistamine substances due to short residency times fol
Braz. J. Pharm. Sci.. Publicado em: 23/09/2019
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21. The efficacy of sustained-release chitosan microspheres containing recombinant human parathyroid hormone on MRONJ
Abstract Treatment of patients with bisphosphonate usage is a significant concern for oral surgeons because it interferes with jaw bone turnover and regeneration. In case of adverse effects manifesting related to bisphosphonate use, oral surgeons are usually treating and keep the patient’s symptoms under control. In this study, we aimed to investigate a ne
Braz. oral res.. Publicado em: 29/08/2019
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22. HISTORICAL PERSPECTIVE OF GASTROESOPHAGEAL REFLUX DISEASE CLINICAL TREATMENT
RESUMO CONTEXTO: A doença do refluxo gastroesofágico (DRGE) é uma das doenças gastrointestinais mais prevalentes, resultando em limitações significativas na qualidade de vida dos pacientes e, também, relevante utilização de recursos médicos. Um melhor entendimento da fisiopatologia da doença nas últimas cinco décadas tem favorecido a evoluçã
Arq. Gastroenterol.. Publicado em: 26/08/2019
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23. Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery
The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A mod
Braz. J. Pharm. Sci.. Publicado em: 15/08/2019
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24. Study on influence of polymer and surfactant on in vitro performance of biodegradable aqueous-core nanocapsules of tenofovirdisoproxil fumarate by response surface methodology
The major objective of this study was to investigate the effect of biodegradable polymer type and surfactant concentration on various characteristics viz. particle size, entrapment efficiency and drug release rate constant of aqueous core nanocapsules (ACNs) containing tenofovirdisoproxil fumarate. In this study, the nanocapsules were prepared by modified mu
Braz. J. Pharm. Sci.. Publicado em: 12/08/2019