Regulatory Function
Mostrando 1-12 de 3523 artigos, teses e dissertações.
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1. Baicalein restrains proliferation, migration, and invasion of human malignant melanoma cells by down-regulating colon cancer associated transcript-1
Baicalein (BAI) is an acknowledged flavonoids compound, which is regarded as a useful therapeutic pharmaceutical for numerous cancers. However, its involvement in melanoma is largely unknown. This study aimed to examine the anti-melanoma function of BAI and unraveled the regulatory mechanism involved. A375 and SK-MEL-28 were treated with BAI for 24 h. Then,
Braz J Med Biol Res. Publicado em: 25/11/2019
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2. Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity
Obesity is often associated with changes in cardiac function; however, the mechanisms responsible for functional abnormalities have not yet been fully clarified. Considering the lack of information regarding high-saturated-fat diet-induced obesity, heart function, and the proteins involved in myocardial calcium (Ca2+) handling, the aim of this study was to t
Braz J Med Biol Res. Publicado em: 27/05/2019
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3. Estado, políticas sociais e direitos sociais: descompasso do tempo atual
Resumo: O artigo apresenta reflexão sobre o descompasso do tempo atual entre a perspectiva dos direitos sociais, as políticas públicas e a ação estatal. Compõe a reflexão discussão sobre os sentidos do público e a falência das políticas sociais e da sua função regulatória e protetiva, no que se refere ao enfrentamento das desigualdades sociais.
Serv. Soc. Soc.. Publicado em: 20/05/2019
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4. Cinco modelos de adjudicação administrativa (Justiça Administrativa)
Resumo Regimes regulatórios e de distribuição de benefícios ocasionam um grande número de disputas individuais entre agências governamentais e particulares. Cada país precisa de um sistema de adjudicação administrativa para solucionar essas disputas corretamente, com justiça e eficiência. Esses sistemas geralmente compreendem três fases - decisã
Rev. Investig. Const.. Publicado em: 15/04/2019
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5. Relationships Between Phenotype and Function of Blood CD4+ T-Cells and Ascending Thoracic Aortic Aneurysm: an Experimental Study
Abstract Introduction: Non-familial ascending thoracic aorta dilation and aneurysms (TAAs) are silent diseases in elderly patients. Histopathology revealed that functionally polarized infiltrating CD4+ T-cells play a key role in aortic wall weakening. Objective: To evaluate the possible associations between phenotype and cytokine production of circulating
Braz. J. Cardiovasc. Surg.. Publicado em: 2019-02
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6. Downregulation of Notch4 - a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma
Resumo Introdução: O carcinoma verrucoso de cavidade oral é uma forma especial de carcinoma de células escamosas bem diferenciada que tem características clínicas, morfológicas e citocinéticas específicas que diferem de outros tipos de cânceres orais. Por essa razão, o diagnóstico requer grande experiência em histopatologia. Portanto, é certam
Braz. j. otorhinolaryngol.. Publicado em: 2019-02
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7. Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge
Among the novel class of endogenous long non-coding RNAs, circular RNA (circRNA) is known as a key regulator in the development and progression of different cancers. Its function and mechanism in the tumorigenesis of colorectal cancer, however, has not been well studied. This study thus aimed to investigate potential regulation of colorectal cancer by circRN
Braz J Med Biol Res. Publicado em: 01/11/2018
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8. Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases
Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Huma
Clinics. Publicado em: 06/09/2018
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9. Imbalance of γδT17/γδTreg cells in the pathogenesis of allergic asthma induced by ovalbumin
We aimed to explore the imbalance between the T helper 17 γδT cells (γδT17) and the regulatory γδT cells (γδTreg) in asthmatic mice. Male Balb/c mice were randomly divided into the normal control group and the asthmatic model group. The asthmatic model group mice were intraperitoneally injected with the mixture of ovalbumin (OVA)/Al(OH)3 and then act
Braz J Med Biol Res. Publicado em: 10/07/2018
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10. HIF-1alpha and infectious diseases: a new frontier for the development of new therapies
ABSTRACT The aim of this review is to show the significant role of HIF-1alpha in inflammatory and infectious diseases. Hypoxia is a physiological characteristic of a wide range of diseases from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydrolase enzymes, which control the protein stability of hypoxia-inducible factor alpha 1 (HIF-1a
Rev. Inst. Med. trop. S. Paulo. Publicado em: 21/12/2017
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11. Immune Regulatory Effects of Enteromorphaclathrata Polysaccharides on Nd Attenuated Vaccine in a Chicken Model Infected with Reticuloendotheliosis Virus
ABSTRACT Reticuloendotheliosis virus (REV) infection has frequently affected the poultry industry in recent years. The infection with REV weakens the immune responses of the infected poultry. It is reported that Enteromorphaclathrata polysaccharides are capable of regulating immune function. In order to investigate the immuno regulatory effects of Enteromorp
Rev. Bras. Cienc. Avic.. Publicado em: 2017-12
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12. Expression analysis of the Arabidopsis thaliana AtSpen2 gene, and its relationship with other plant genes encoding Spen proteins
Abstract Proteins of the Split ends (Spen) family are characterized by an N-terminal domain, with one or more RNA recognition motifs and a SPOC domain. In Arabidopsis thaliana, the Spen protein FPA is involved in the control of flowering time as a component of an autonomous pathway independent of photoperiod. The A. thaliana genome encodes another gene for a
Genet. Mol. Biol.. Publicado em: 28/08/2017