Regulatory Function
Mostrando 13-24 de 3523 artigos, teses e dissertações.
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13. Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia
Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effector T cell activation is an important mechanism in the pathogenesis of ITP. Regulatory T cells (Treg) have a strong immunosuppressive function for T cell activation and their importance in the pathophysiology and clinical treatment of ITP has been confirmed.
Braz J Med Biol Res. Publicado em: 16/02/2017
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14. Regulation of gene expression: Cryptic β-glucoside (bgl) operon of Escherichia coli as a paradigm
Bacteria have evolved various mechanisms to extract utilizable substrates from available resources and consequently acquire fitness advantage over competitors. One of the strategies is the exploitation of cryptic cellular functions encoded by genetic systems that are silent under laboratory conditions, such as the bgl (β-glucoside) operon of E. coli. The bg
Braz. J. Microbiol.. Publicado em: 2014-12
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15. Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome
In this study, biomarkers and transcriptional factor motifs were identified in order to investigate the etiology and phenotypic severity of Down syndrome. GSE 1281, GSE 1611, and GSE 5390 were downloaded from the gene expression ominibus (GEO). A robust multiarray analysis (RMA) algorithm was applied to detect differentially expressed genes (DEGs). In order
Braz J Med Biol Res. Publicado em: 08/08/2014
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16. Ethylene response factors gene regulation and expression profiles under different stresses in rice
Stresses can cause large yield reductions in cultivated plants. The response to these stresses occurs via a plethora of signalling pathways, where a large number of genes is induced or repressed. Among the environmental stress responsive genes, there are the members of the ethylene response factors (ERF) gene family. The mRNA levels of different ERF are regu
Theor. Exp. Plant Physiol.. Publicado em: 2013-12
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17. Functional characterization of sugarcane mustang domesticated transposases and comparative diversity in sugarcane, rice, maize and sorghum
Transposable elements (TEs) account for a large portion of plant genomes, particularly in grasses, in which they correspond to 50%-80% of the genomic content. TEs have recently been shown to be a source of new genes and new regulatory networks. The most striking contribution of TEs is referred as “molecular domestication”, by which the element coding seq
Genetics and Molecular Biology. Publicado em: 05/07/2012
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18. Thymopoiesis and regulatory T cells in healthy children and adolescents
OBJECTIVES: The purpose of this study was to investigate the association between T cell receptor excision circle levels in peripheral blood mononuclear cells and regulatory T cells that co-express CD25 and Foxp3 in healthy children and adolescents of different ages. MATERIALS AND METHODS: The quantification of signal-joint T-cell receptor excision circle lev
Clinics. Publicado em: 2012
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19. Papel de SOCS2 na resposta imune e função cardíaca durante a infecção experimental por Trypanosoma cruzi
Infection with Trypanosoma cruzi induces robust inflammation that limits parasite proliferation but may result in Chagas heart disease. The 5-Lipoxygenase pathway induces suppressor of cytokine signaling(SOCS)2 expression, an important regulator of immune responses. Here, we investigated the role of SOCS2 for the pathogenesis of T. cruzi infection. We invest
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011
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20. Estudos funcionais da proteína reguladora humana Ki-1/57 e seus parceiros de interação / Functional studies of the human regulatory protein Ki-1/57 and its interaction partners
The protein Ki-1/57 was discovered through cross reactivity of the monoclonal antibody Ki-1 in cells of Hodgkin lymphoma. Previously studies demonstrated that Ki-1/57 interacts with RACK-1 protein, undergoes phosphorylation by PKCs and methylation by PRMT1, an arginine methyltransferase that modulates several RNA binding proteins. Studies have shown that Ki-
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/07/2011
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21. Avaliação do efeito de contraceptivos hormonais sobre o sistema complemento / Evaluation of the effect of hormonal contraceptives on the complement system
The occurrence of thrombosis is often associated with the presence of one or more risk factors, which may be genetic and/or acquired, such as hormonal changes that occur during pregnancy, hormone replacement therapy and the use of combined hormonal contraceptives (CHC). The inflammation in turn, is an important body\ s response to the aggression and involves
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2011
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22. O novo perfil da culpa na responsabilidade civil: a culpa como critério para gradação da indenização / The new profile of negligence on torts: negligence as a criterion for defining the indemnity
This thesis aims to conduct a technical study of the structural and functional profiles of negligence based on the new regulatory framework introduced into Brazilian Law by the sole paragraph of Article 944 of the Civil Code. By examining the regulations regarding negligence in the field of torts, it is shown in this paper that, notwithstanding the rise in t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/03/2011
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23. Imunodetecção do receptor metabotrópico mGluR8 no núcleo arqueado do hipotálamo de ratos Wistar e estudo dos efeitos, no receptor, resultantes da exposição oral sub-crônica ao glutamato monossódico / Imunodetecction of mGluR8 receptor in the arcuate nucleus of the hypothalamus of Wistar rats and study of the effects, on the receptor, resulting from sub-chronic exposure to monosodium glutamate
Food is part of human culture not only associated to physiological needs. Food is composed of several molecules among them amino acids. Glutamate (GLU) is the anion of one of the main amino acids found in foods that, besides being part of the food composition, is a molecule essential for human physiology. It can also be ingested due to the use of the food ad
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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24. Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants
Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has recently become appreciated. Physiological cardiac hypertrophy involves complex cardiac remodeling that occ
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-09