Receptors Serotonin
Mostrando 1-12 de 224 artigos, teses e dissertações.
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1. Short-term oral administration of risperidone induces pancreatic damage and hyperamylasemia in Sprague-dawley rats
Risperidone is an atypical antipsychotic acting mainly as a dopamine D2 and serotonin 5-HT2 receptors antagonist prescribed in the treatment of schizophrenia and various affective disorders. Risperidone has been reported to be associated with weight gain, panreatitis and type 2 diabetes mellitus. Various mechanisms of risperidone-induced toxicities have been
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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2. Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents
Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with several neurological and mental disorders, including abnorma
Braz J Med Biol Res. Publicado em: 14/06/2018
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3. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect
Abstract Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acut
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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4. Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation
Pharmacological treatment of inflammatory pain is usually done by administration of non-steroidal anti-inflammatory drugs (NSAIDs). These drugs present high efficacy, although side effects are common, especially gastrointestinal lesions. One of the pharmacological strategies to minimize such effects is the combination of drugs and natural products with syner
Braz J Med Biol Res. Publicado em: 20/06/2016
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5. Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice
ABSTRACT The most recently identified serotonin (5-HT) receptor is the 5-HT7 receptor. The antinociceptive effects of a 5-HT7 receptor agonist have been shown in neuropathic and inflammatory animal models of pain. A recent study demonstrated the functional expression of 5-HT7 receptors in the substantia gelatinosa (SG) of the trigeminal subnucleus caudalis,
J. Appl. Oral Sci.. Publicado em: 2016-06
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6. Efeitos da restrição proteica gestacional em hipocampo de ratos machos adultos : avaliação da estrutura dendrítica tridimensional, do comportamento e de componentes neuroquímicos = Effects of gestational protein restriction in hippocampus of adult male rats / Effects of gestational protein restriction in hippocampus of adult male rats : evaluation of three-dimensional dendritic structure of hippocampal neurons, behavior and neurochemical components
Studies have demonstrated that maternal nutritional restriction during pregnancy or in early postnatal life results in hippocampus cognitive impairment and structural abnormalities in the 16-wk-old offspring. In an attempt to analyze whether gestational protein restriction might induce learning and memory impairment associated with structural changes in the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/07/2012
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7. Efeito da microinjeção do agonista dos receptores 5-HT1A, F15599, na região ventro-orbital do córtex pré-frontal no comportamento agressivo de camundongos machos submetidos à provocação social
The serotonergic system has long been linked to aggressive behavior and particularly 5-HT1A receptor subtype is involved in modulation of aggressiveness. Previous studies using agonists that act selectively on these receptors showed both reduction and increased aggression. It is known that these receptors are found in several brain regions where they act as
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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8. Efeito ansiolítico do ondansetron, antagonista dos receptores 5-HT3, injetado na amídala de camundongos submetidos à exposição e reexposição no labirinto em cruz elevado
Against of stimuli that are dangerous, animals manifest defense reactions that cause fear and anxiety. These stimuli activate the serotonergic system, which sends projections to structures involved in defense mechanisms such as the septum, hypothalamus, hippocampus, amygdala and periaqueductal gray modulates the behavioral changes that can be characterized a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2011
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9. Avaliação do papel da 5-hidroxitriptamina (5-HT) no processamento periférico da resposta nociceptiva
5-Hydroxytryptamine (5-HT, serotonin) is a cell-derived vasoactive amine, released primarily by platelets (in humans), mast cells (in rodents) and endothelial cells. It is a regulator of smooth muscle in the cardiovascular and gastrointestinal systems, an enhancer of platelet aggregation, and a neurotransmitter in the central nervous system. Although 5-HT is
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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10. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO / ANTIDEPRESSANT-LIKE PHARMACOLOGICAL PROFILE OF 3-(4- FLUOROPHENYLSELENYL)-2,5-DIPHENYLSELENOPHENE: INVOLVEMENT OF SEROTONERGIC SYSTEM
Depression is a serious, recurrent and incapacitating psychiatric condition with a heavy social burden. The pharmacological approach to this disorder employs therapy with antidepressant drugs, which have side effects and numerous limitations. In view of the promising pharmacological properties of containing-selenium molecules, this study evaluated the effect
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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11. InvestigaÃÃo da aÃÃo central do carvacrol em modelos de ansiedade, depressÃo e convulsÃo em camundongos e possÃveis mecanismos farmacolÃgicos envolvidos. / Investigation of central actions of carvacrol in animal models of anxiety, depression and convulsion in mice and possible pharmacological mechanisms involved.
Carvacrol (5-Isopropyl-2-methylphenol) is a monoterpenic phenol present in the essencial oil of many plants. It is the major component of the essential oil fraction of oregano and thyme. This work presents the behavioral effects of carvacrol in animal models of anxiety, depression, sedation and convulsion, such as, elevated plus maze (EPM), open field, rota
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/01/2010
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12. Effect of carotid and aortic baroreceptors on cardiopulmonary reflex: the role of autonomic function
We determined the sympathetic and parasympathetic control of heart rate (HR) and the sensitivity of the cardiopulmonary receptors after selective carotid and aortic denervation. We also investigated the participation of the autonomic nervous system in the Bezold-Jarish reflex after selective removal of aortic and carotid baroreceptors. Male Wistar rats (220-
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07