Receptors Muscarinic
Mostrando 13-24 de 334 artigos, teses e dissertações.
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13. Participation of the muscarinic receptors and of the nitric oxide pathway in the spasmolytic effect of the total alkaloids fraction obtained from Solanum paludosum Moric. (SOLANACEAE) / Participação de receptores muscarínicos e da via do óxido nítrico no efeito espasmolítico da fração de alcalóides totais obtida de Solanum paludosum Moric: (Solanaceae)
Solanum paludosum Moric. (Solanaceae) é uma espécie herbácea, conhecida popularmente como jurubeba-roxa no Nordeste do Brasil (AGRA; BHATTACHARYYA, 1999). O estudo químico e farmacológico com a casca da raiz desta espécie mostrou a presença de glicoalcalóides, e que o extrato etanólico e a fase aquosa obtidos da mesma parte mostraram atividade espas
Publicado em: 2009
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14. Trypanosoma cruzi infection induces up-regulation of cardiac muscarinic acetylcholine receptors in vivo and in vitro
The pathogenesis of chagasic cardiomyopathy is not completely understood, but it has been correlated with parasympathetic denervation (neurogenic theory) and inflammatory activity (immunogenic theory) that could affect heart muscarinic acetylcholine receptor (mAChR) expression. In order to further understand whether neurogenic and/or immunogenic alterations
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-09
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15. Participação da área septal medial nas respostas sialogoga, dipsogênica e cardiovascular induzidas pela pilocarpina
Peripheral injection of pilocarpine (PILO, 1 mg/Kg of body weight), muscarinic cholinergic agonist, induce salivation, water intake and pressor response. The medial septal area (MSA) is an important brain area involved in cardiovascular regulation and hydroelectrolytic control. In this present study, we investigated: 1) the effect of MSA electrolytic lesion
Publicado em: 2008
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16. Development of fetal nicotine and muscarinic receptors in utero
The role of acetylcholine in the central and peripheral nervous systems is well established in adults. Cholinergic modulation of vascular functions and body fluid balance has been extensively studied. In the embryo-fetus, cholinergic receptors are widespread in the peripheral and central systems, including smooth muscle and the epithelial lining of the cardi
Brazilian Journal of Medical and Biological Research. Publicado em: 26/03/2007
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17. A fadiga no exercício físico é modulada pela neurotransmissão colinérgica nos núcleos ventromediais hipotalâmicos, em ambiente frio
Cholinergic blockade in the ventromedial hypothalamic nucleus (VMH) reduces tail heat loss and induces a higher increase in the heat storage rate during physical exercise, antecipating the onset of fatigue in 37%. Although the evidences indicating the involvement of VMH cholinergic receptors on thermoregulation during the exercise until fatigue, the control
Publicado em: 2007
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18. O exercício físico induz ajustes termorregulatórios e cardiovasculares que são mediados pela neurotransmissão colinérgica dos núcleos ventromediais hipotalâmicos
The aim of this study was to evaluate the participation of cholinergic muscarinic receptors in the ventromedial hypothalamic nuclei (VMH) on heat balance, cardiovascular adjustments and central fatigue during treadmill exercise (24 m.min1, 5% inclination). Rats were submitted to two experimental situations separated by an interval of at least two days. Tail
Publicado em: 2006
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19. Influência do Sistema Colinérgico na sensibilização ao efeito estimulante do etanol. / Influência do Sistema Colinérgico na sensibilização ao efeito estimulante do etanol.
Various neurotransmission systems have influence on the behavioral sensitization process developed after repeated administration of some drugs of abuse, among them the cholinergic system, which modulates the dopaminergic pathways functioning. In this study we evaluated the influence of scopolamine (an antagonist of cholinergic muscarinic receptors) on the de
Publicado em: 2006
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20. Efeito do treinamento físico na cardiomiopatia induzida por hiperatividade simpática em camundongos com ablação dos receptores alpha 2A/alpha 2C- adrenérgicos / Effect of exercise training on cardiomyopathy induced by sympathetic hiperactivity in mice lacking a2A/a2C- adrenoceptors
Presynaptic a2-adrenoceptors (a2 AR) regulate the cardiovascular function by inhibiting neurotransmitter release on the sympathetic nerve terminals. We have recently reported that disruption for both a2A and a2C AR subtypes in mice (KO) leads to sympathetic hyperactivity with evidence of cardiac dysfunction by 4 mo of age. These mice provide a model system f
Publicado em: 2006
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21. Negative inotropic and chronotropic effects on the guinea pig atrium of extracts obtained from Averrhoa carambola L. leaves
It has been reported that star fruit can lead to a fatal outcome in uremic patients. The intoxication syndrome consists of hiccups, mental confusion, dizziness, and vomiting. On the other hand, folk medicine uses teas and infusions of carambola leaves to treat headache, vomiting, cough, insomnia, and diabetes. This motivated us to determine if Averrhoa caram
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-07
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22. Ação de drogas agonistas e antagonistas dos sistemas colinérgico e dopaminégico: estudo comportamental e neuroquímico em corpo estriado de rato. / The action of the agonists and antagonists drugs of cholinergic and dopaminergic systems: behavioral and neurochemical study in striatum of rats
In the study, the interaction between the dopaminergic and cholinergic systems through the study of behavioral (open field and catalepsy) and neurochemical (density of dopaminergic receptor (D1 and D2-like) and muscarinic (M1+M2-like)) effect in striatum rat was evaluated. The following drugs were used: mazindol (indirect dopaminergic agonist), apomorphine (
Publicado em: 2005
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23. Effects of Levetiracetam on pilocarpine-induced seizures in mice / Efeitos do levetiracetan no modelo de convulsões induzidas por pilorcarpina em camundongos
Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures and in experimental models of seizures, including pilocarpine-induced seizures in rodents. Objectifying to clarify if anticonvulsant activity of LEV occurs near cholinergic muscarinic alterations, adult male mice received LEV injections before muscarinic agon
Publicado em: 2005
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24. Evaluation of the central effects of yangambin isolated from Ocotea duckei Vattimo: Behavioral and neurochemical study in mice motor cortex and striatum / Avaliação dos efeitos centrais da iangambina isolada de Ocotea duckei Vattimo: Estudo comportamental e neuroquímico em córtex motor e corpo estriado de camundongo
The effects of the acute administration of yangambin (25, 50 and 75 mg/kg intraperitoneal and oral), were studied in some animals behavioral models (open field, rotarod, forced swimming test, barbiturate-induced sleeping time, hole board, elevated plus maze, pentilenotetrazole-induced convulsion). Binding in vitro with differents concentrations of yangambin
Publicado em: 2005