Rational
Mostrando 13-24 de 1517 artigos, teses e dissertações.
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13. A IMPORTÂNCIA DAS CUMARINAS PARA A QUÍMICA MEDICINAL E O DESENVOLVIMENTO DE COMPOSTOS BIOATIVOS NOS ÚLTIMOS ANOS
Coumarins are natural products characterized as 2H-chromen-2-one, according to IUPAC nomenclature, largely distributed in plants, as well as, in species of fungi and bacteria. Nowadays, many synthetic procedures allow the discovery of coumarins with expanded chemical space. The ability to exert non-covalent interactions with many enzymes and receptors in liv
Quím. Nova. Publicado em: 2021-02
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14. A rational pharmacologic approach toward a biologically meaningful subtype of autism spectrum disorder,
Abstract Objective: To verify the relationship between sleep characteristics and motor development in low-birth-weight preterm infants during infancy and preschool years. Method: Forty-one healthy preterm infants (<37 weeks’ gestation) with low birth weight (≤1500 g) were assessed longitudinally at three different time points: at 6 months of corrected
J. Pediatr. (Rio J.). Publicado em: 2021-02
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15. Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
ABSTRACT BACKGROUND: The World Health Organization has declared that a pandemic situation exists in relation to the disease caused by the new coronavirus, COVID-19. So far, the absence of a vaccine against the new coronavirus has led people worldwide to seek various therapeutic alternatives, including use of cholecalciferol. DESIGN AND SETTING: Narrative
Sao Paulo Med. J.. Publicado em: 2021-02
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16. Reliability and geotechnical safety applied to deep foundations in precast concrete piles - case study
Abstract The Brazilian standard pertinent to the design and execution of foundations, NBR 6122/2019, establishes that the safety inspection of foundations of a given project must be conducted based on compliance with specified safety factors. Safety factor verification is imperative to meet regulatory requirements; however, it is not enough to guarantee the
REM, Int. Eng. J.. Publicado em: 2021-01
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17. Teleconsultation and Teletreatment Protocol to Diagnose and Manage Patients with Benign Paroxysmal Positional Vertigo (BPPV) during the COVID-19 Pandemic
Abstract Introduction Telehealth consists in the application of technology to provide remote health service. This resource is considered safe and effective and has attracted an exponential interest in the context of the COVID pandemic. Expanded to dizzy patients, it would be able to provide diagnosis and treatment, minimizing the risk of disease transmissio
Int. Arch. Otorhinolaryngol.. Publicado em: 2021-01
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18. Health-related quality of life in patients treated with atypical antipsychotics
Objective: To assess health-related quality of life and associated factors in patients treated with atypical antipsychotics, as well as to determine utility values using the EuroQol-5D-3L instrument. Methods: A cross-sectional study was conducted at a state-run pharmacy in the Brazilian National Health System. Individuals were included if they were using a
Braz. J. Psychiatry. Publicado em: 2020-12
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19. Production of functional products using grape processing residuals
Abstract The viticulture – winemaking of Azerbaijan has a rich history and traditions. Grapes have been cultivated and wine made in these places since the ancient times. In the 1980s, the field was in a boom period and provided economic benefits at a level comparable to the country's oil industry revenues. Although the area is currently experiencing a rece
Food Sci. Technol. Publicado em: 2020-12
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20. Peculiarities of drilling and blasting in underground small-scale mines
Abstract Artisanal and Small-scale Mining (ASM) is a prominent activity in the extractive industry: considering only gold, it produces about 20% of the world market supply. Despite this fact, ASM is generally associated with the negative aspects of its environ mental impact, and operational research is generally neglected. This article empha sizes the peculi
REM, Int. Eng. J.. Publicado em: 2020-09
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21. Mechanistic Investigation of DBU-Based Ionic Liquids for Aza-Michael Reaction: Mass Spectrometry and DFT Studies of Catalyst Role
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-based ionic liquids (ILs) has exhibited a high catalytic activity in the aza-Michael reactions compared to conventional catalysts and with imidazole-based ILs. In the present work DBU-based ILs showed high catalytic potential for aza-Michael addition of aromatic amines to 2-cyclohexen-1-one under solvent-free conditio
J. Braz. Chem. Soc.. Publicado em: 2020-09
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22. On the possibility of obtaining high-quality lyophilized collagen hydrolysate and its applicability in the sausage production
Abstract The paper discusses the issues of rational use of secondary collagen-containing raw material in the food industry, namely cattle by-products. The technology of obtaining collagen hydrolysate from this type of raw material with the subsequent freeze-drying is proposed, which maximizes the level of preservation of native properties and the expands the
Food Sci. Technol. Publicado em: 2020-09
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23. SYNERGISMS BETWEEN METAL AND PHOTOREDOX CATALYSIS: DECONVOLUTING COMPLEX SYSTEMS
This review briefly describes the evolution of organometallic chemistry and photoredox catalysis as independent fields; followed by a more in-depth presentation and discussion of representative examples derived from their synergistic combination, which generally leads to powerful cross-coupling protocols. In this context, the rational deconvolution of these
Quím. Nova. Publicado em: 20/07/2020
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24. EVOLUÇÃO DIRIGIDA DE ENZIMAS: PEQUENAS MODIFICAÇÕES, MELHORES BIOCATALISADORES
Biocatalysis is now a mature field, both in the laboratory and industrial scale. This approach counts on enzyme high selectivity, biodegradability, elegant control over the outcome of reaction conditions and as a possible solution to address some challenges in Green Chemistry faced by synthetic organic chemists. However, many wild-type ready-to-use enzymes w
Quím. Nova. Publicado em: 2020-06