Rat Platelets
Mostrando 1-12 de 62 artigos, teses e dissertações.
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1. Brain ischemia alters platelet ATP disphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats
The effects of transient forebrain ischemia, reperfusion and ischemic preconditioning on rat blood platelet ATP diphosphohydrolase and 5'- nucleotidase activities were evaluated. Adult Wistar rats were submitted to 2 or 10 min of single ischemic episodes, or to 10 min of ischemia 1 day after a 2-min ischemic episode (ischemic preconditioning) by the four-ves
Publicado em: 2010
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2. Modulação da adesão plaquetaria de ratos tratados com lipopolissacarideo por especies reativas de oxigenio e nitrogenio / Reactive oxygen and nitrogen species modulate the ex-vivo effects of LPS on platelet adhesion to fibrinogen
Platelets are known as hemostatic regulators, but multiple studies have shown that platelets are important in inflammatory reactions including sepsis. Lipopolysaccharide (LPS) is a component of the outer membrane of Gram negative bacteria and has a pivotal role in inducing Gram negative sepsis. LPS triggers the production of various substances including nitr
Publicado em: 2010
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3. Avaliação do efeito relaxante do BAY 41-2272 em detrusor isolado de coelhos / Evaluation of relaxant effect of BAY 41-2272 in rabbit isolated detrusor
Overactive bladder (OAB) is a highly prevalent condition that affects millions of people worldwide with a profound effect on quality of life. The bladder overactivity is related to spontaneous contractions of the detrusor smooth muscle causing an increase in the intravesical pressure and consequently stimulation of the micturirion reflex. Evidences suggest t
Publicado em: 2009
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4. Modulation in pharmacological action of botropics and crotalics PLA2 in presence of an lectin isolated from marine alga Bryothammion triquetrum / Modulação da ação farmacologica de PLA2 botropicas e crotalicas em presença de uma lectina isolada da alga marinha Bryothamnion triquetrum
Lectins are proteins that bind specifically and reversibly to carbohydrates. They are widely distributed among living organisms and show many activities of biological and medical interest. In this work, two isoforms of lectins isolated from the red marine alga Bryothamnion triquetrum were purified by ion exchange followed by reverse phase chromatographies. T
Publicado em: 2007
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5. Brain ischemia alters platelet ATP diphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats
The effects of transient forebrain ischemia, reperfusion and ischemic preconditioning on rat blood platelet ATP diphosphohydrolase and 5'-nucleotidase activities were evaluated. Adult Wistar rats were submitted to 2 or 10 min of single ischemic episodes, or to 10 min of ischemia 1 day after a 2-min ischemic episode (ischemic preconditioning) by the four-vess
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-11
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6. Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures.
A growth factor (HGF) stimulating DNA synthesis of adult rat hepatocytes in primary culture was found in rat platelets. HGF was purified from rat platelets to homogeneity by a three-step procedure: stimulation of its release from platelets by thrombin, cation-exchanger fast protein liquid chromatography on a Mono S column, and heparin-Sepharose chromatograph
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7. Platelets of the Wistar Furth rat have reduced levels of alpha-granule proteins. An animal model resembling gray platelet syndrome.
Rats of the Wistar Furth (WF) strain have hereditary macrothrombocytopenia (large mean platelet volume [MPV] with increased platelet size heterogeneity and reduced platelet count). Ultrastructural studies suggest that this anomaly results from erratic subdivision of megakaryocyte cytoplasm into platelets. In this study, we have examined protein profiles of p
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8. Interaction of rat platelets with Listeria monocytogenes.
Listeria monocytogenes induced aggregation of rat platelets in vitro and stimulated the nonlytic release of [3H]serotonin. Listeria-induced platelet aggregation and serotonin release required the presence of intact Listeria, was maximal at a 1:1 Listeria/platelet ratio, required a plasma cofactor, and was not inhibited by indomethacin, acetylsalicylic acid,
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9. Catecholamine Uptake, Accumulation, and Release in Acute Porphyria
Hypertension and tachycardia are well known features of acute porphyria and have been shown to be related to increased circulating catecholamines. The mechanism by which circulating catecholamines are increased was studied using the isolated perfused rat heart and human platelets as a model of adrenergic neuronal function. It was found that neither δ-aminol
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10. Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery.
Intimal lesion formation was investigated in rats made thrombocytopenic by a single i.p. injection of a polyclonal antibody made against rat platelets that reduced circulating platelet counts to less than 1% of normal. The carotid artery was then denuded of endothelium with a 2 French balloon catheter, after which no platelets were found adhering to the expo
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11. Platelets mediate neutrophil-dependent immune complex nephritis in the rat.
Neutrophils and platelets are frequently present in glomeruli in immune glomerulonephritis (GN). No role for the platelet in acute neutrophil-mediated renal injury has been defined. We investigated a neutrophil-mediated model of subendothelial immune complex GN in the rat. Rats were platelet-depleted (mean platelet less than 10,000/microliter) with goat anti
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12. Cytochemical localization of lysosomal enzymes in rat megakaryocytes and platelets.
Platelets secrete lysosmal enzymes during the "platelet release reaction" early in clot formation. This study was undertaken to identify primary lysosomes of platelets and to detemine their origin in megakaryocytes. Using electron microscopy and cytochemistry, we localized two lysosomal enzymes, arylsulfatase and acid phosphatase, in megakaryocytes and plate