Rankl
Mostrando 13-24 de 184 artigos, teses e dissertações.
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13. Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis
Abstract Objective: This study aimed to evaluate the effect of avocado/soybean unsaponifiables (ASU) on periodontal repair in rats with induced periodontitis and arthritis. Methodology: Forty-five rats were submitted to periodontitis induction by insertion of ligatures into the upper second molars, maintained for 15 days. These animals were randomly alloca
J. Appl. Oral Sci.. Publicado em: 09/09/2019
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14. Clinical attachment loss and molecular profile of inflamed sites before treatment
Abstract Objective: To monitor early periodontal disease progression and to investigate clinical and molecular profile of inflamed sites by means of crevicular fluid and gingival biopsy analysis. Methodology: Eighty-one samples of twenty-seven periodontitis subjects and periodontally healthy individuals were collected for the study. Measurements of clinica
J. Appl. Oral Sci.. Publicado em: 09/09/2019
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15. Treatment of bisphosphonate-related osteonecrosis using platelet-rich plasma: microtomographic, microscopic, and immunohistochemical analyses
Abstract The present study aimed to investigate the use of platelet-rich plasma (PRP) on tooth extraction sites in rats treated with bisphosphonates. Thirty Albinus Wistar male rats were administered 0.035 mg/kg zoledronic acid intravenously for 8 weeks, divided into four administrations with a 2-week interval between each application, after which their uppe
Braz. oral res.. Publicado em: 01/07/2019
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16. Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage
Abstract Objectives: Infection, inflammation and bone resorption are closely related events in apical periodontitis development. Therefore, we sought to investigate the role of cyclooxygenase (COX) in osteoclastogenesis and bone metabolism signaling in periapical bone tissue after bacterial lipopolysaccharide (LPS) inoculation into root canals. Methodology
J. Appl. Oral Sci.. Publicado em: 03/06/2019
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17. Effect of risperidone on proliferation and apoptosis of MC3T3-E1 cells
This aim of this study was to assess the molecular mechanism of osteoporosis in schizophrenia patients with risperidone use. Here, we investigated the effects of risperidone on cellular proliferation and apoptosis of a preosteoblast cell line, MC3T3-E1. Cell viability and apoptotic rate of MC3T3-E1 were detected by cell counting kit-8 and flow cytometry at a
Braz J Med Biol Res. Publicado em: 25/02/2019
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18. Gliclazide reduced oxidative stress, inflammation, and bone loss in an experimental periodontal disease model
Abstract Objective The aim of this study was to evaluate the effects of gliclazide on oxidative stress, inflammation, and bone loss in an experimental periodontal disease model. Material and Methods Male albino Wistar rats were divided into no ligature, ligature, and ligature with 1, 5, and 10 mg/kg gliclazide groups. Maxillae were fixed and scanned usin
J. Appl. Oral Sci.. Publicado em: 21/02/2019
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19. Effect of ProRoot MTA® and Biodentine® on osteoclastic differentiation and activity of mouse bone marrow macrophages
Abstract Objectives This investigation aimed to assess the differentiation inhibitory effects of ProRoot MTA® (PMTA) and Biodentine® (BIOD) on osteoclasts originated from murine bone marrow macrophages (BMMs) and compare these effects with those of alendronate (ALD). Materials and Methods Mouse BMMs were cultured to differentiate into osteoclasts with ma
J. Appl. Oral Sci.. Publicado em: 07/01/2019
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20. A novel effect of geraniin on OPG/RANKL signaling in osteoblasts
In this study, the effects of geraniin on osteoprotegerin/receptor activator of nuclear factor-κB ligand(OPG/RANKL) in regulating the proliferation of osteoblasts and suppression of osteoclast-like cells (OLC) in OLC-osteoblast co-cultured system in vitro were investigated. Osteoblasts were cultured and identified with alkaline phosphatase (ALP), gomori sta
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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21. Immunohistochemical expression of RANKL in oral giant cell lesions is predictive of aggressiveness
Abstract The aim of this study was to evaluate the immunohistochemical expression of receptor activator of nuclear factor kappa-B ligand (RANKL) and of osteoprotegerin (OPG), important proteins correlated with osteoclastogenesis, in central giant cell lesions (CGCL) and peripheral giant cell lesions (PGCL) and to compare their expression with the histologica
Braz. oral res.. Publicado em: 29/10/2018
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22. Experimental furcal perforation treated with mineral trioxide aggregate plus selenium: immune response
Abstract The aim of this study is to evaluate the expression of cytokines in response to mineral trioxide aggregate (MTA) plus selenium in germ-free mice with experimental furcal perforation. The first left maxillary molar was opened, and the furcal area was perforated and treated with post-MTA-Se (experimental group). The same surgical intervention was perf
Braz. oral res.. Publicado em: 11/10/2018
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23. Up-regulated expression of CD147 gene in malignant bone tumor and the possible induction mechanism during osteoclast formation
It is increasingly evident that the microenvironment of bone can influence cancer phenotype in many ways that favor growth in bone. CD147, a transmembrane protein of the immunoglobulin (Ig) superfamily, was identified independently in different species and has many designations across different species. However, expression levels of CD147 mRNA in bone cancer
Braz J Med Biol Res. Publicado em: 23/07/2018
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24. Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice
Abstract Objective To evaluate and correlate, in the same research, the mRNA expression and the staining of RANK, RANKL, OPG, TLR2 and MyD88 by immunohistochemistry in the apical periodontitis (AP) progression in mice. Material and Methods AP was induced in the lower first molars of thirty-five C57BL/6 mice. They were assigned to four groups according to
J. Appl. Oral Sci.. Publicado em: 10/07/2018