Radiochemical Analysis
Mostrando 1-12 de 23 artigos, teses e dissertações.
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1. Functional investigation of bone implant viability using radiotracers in a new model of osteonecrosis
OBJECTIVES: Conventional imaging methods are excellent for the morphological characterization of the consequences of osteonecrosis; however, only specialized techniques have been considered useful for obtaining functional information. To explore the affinity of radiotracers for severely devascularized bone, a new mouse model of isolated femur implanted in a
Clinics. Publicado em: 2016-10
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2. Synthesis and antimicrobial evaluation of two peptide LyeTx I derivatives modified with the chelating agent HYNIC for radiolabeling with technetium-99m
Abstract Background Current diagnostic methods and imaging techniques are not able to differentiate septic and aseptic inflammation. Thus, reliable methods are sought to provide this distinction and scintigraphic imaging is an interesting option, since it is based on physiological changes. In this context, radiolabeled antimicrobial peptides have been inve
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/05/2016
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3. Alternative chromatographic system for the quality control of lipophilic technetium-99m radiopharmaceuticals such as [99mTc(MIBI)6]+
Knowledge of the radiochemical purity of radiopharmaceuticals is mandatory and can be evaluated by several methods and techniques. Planar chromatography is the technique normally employed in nuclear medicine since it is simple, rapid and usually of low cost. There is no standard system for the chromatographic technique, but price, separation efficiency and s
Braz J Med Biol Res. Publicado em: 03/03/2015
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4. Utilização de líquens como bioindicadores de contaminação atmosférica por radionuclídeos naturais e metais em região impactada por TENORM / The use of lichens as bioindicators of atmospheric contamination by natural radionuclides and metals in a region impacted by TENORM
The main aim of this thesis is to study the possibility of using lichen as bioincicator of atmospheric pollution in regions contaminated by radionuclides, metals and rare earth elements. Two regions were chosen, one in Pirapora do Bom Jesus, where a tin and lead industry is located, and a second one in Cubatão, where a phosphate fertilizer industrial comple
Publicado em: 2010
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5. EVALUATION OF RADIOLABELING OF ANNEXIN A5 WITH TECHNETIUM-99m: INFLUENCE OF THE LABELING METHODS ON PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF THE COMPOUNDS / Avaliação da radiomarcação da anexina A5 com Tecnécio-99m: influência do método de marcação nas propriedades físicos-químicas e biológicas do composto
Annexin A5 (ANXA5) is an intracellular human protein of 36 kDa with high affinity for membrane-bound phosphatidylserine that is selectively exposed on the surface of cells undergoing apoptosis. Apoptosis is important in normal physiology and innumerous pathologic states. Clinical applications for ANXA5 imaging are being developed in oncology, organ transplan
Publicado em: 2009
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6. Síntese, análise, purificação e biodistribuição em modelo animal do Radiofármaco 177Lu3+-dotatato para uso diagnóstico e terapêutico em tumores neuroendócrinos / SYNTHESIS, ANALYSIS, PURIFICATION AND BIODISTRIBUTION IN AN ANIMAL MODEL OF RADIOPHARMACEUTICAL 177Lu3+- DOTATATO FOR DIAGNOSTIC AND THERAPEUTIC USE IN NEUROENDOCRINE TUMORS
The aim of this work was to propose rationalization in the synthesis, analysis and purification of radiopharmaceutical 177Lu3+-DOTATATO for diagnostic and therapeutic use in neuroendocrine tumors, as well as for evaluating biodistribution of this radiopharmaceutical in an animal-model. The complexation reaction for the synthesis of radiopharmaceutical was ca
Publicado em: 2009
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7. Participação de complexos de lantanídeos entre as fases de reservatório de petróleo
Traçadores são utilizados na explotação de reservatórios de petróleo para fornecer informações que auxiliam na otimização das operações envolvidas. Esta utilização já é comumente praticada fora do Brasil, sendo os mais empregados os radioativos, que apresentam sobre os compostos químicos as vantagens da simplicidade e sensibilidade de detec�
Publicado em: 2007
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8. Talinum patens: Análise por ativação neutrônica instrumental e prospecção fitoquímica
The use of plants for many diseases treatment is a millenary knowledge. These are the great importance for the formation of actual medicine bases. Actually, more than 25 % of the all drugs prescribed in the world are obtained from plants. The medicinal plants and other vegetable materials market reach to around two billions dollars. The researches of natural
Publicado em: 2005
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9. Structure of the heavy chain of the H-2Kk histocompatibility antigen.
We have used radiochemical techniques to characterize the heavy chain (Mr 46,000) of the murine H-2Kk histocompatibility antigen in terms of six fragments (I-VI) obtained after cleavage of the polypeptide chain with CNBr. The tentative order of the fragments, which account for more than 90% of the heavy chain, was assigned by radiochemical sequence analysis
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10. Identification of phosphorylated 422(aP2) protein as pp15, the 15-kilodalton target of the insulin receptor tyrosine kinase in 3T3-L1 adipocytes.
[32P]pp15, the [32P]phosphorylated form of a specific cytosolic substrate of the insulin receptor tyrosine kinase, was purified to homogeneity from mouse 3T3-L1 adipocytes incubated with 32Pi. Evidence presented here and previously indicates that pp15 contains a single phosphotyrosine residue. Alkylated [32P]pp15 was subjected to limited digestion with tryps
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11. Mercury and selenium concentrations and their interrelations in organs from dental staff and the general population.
Mercury (Hg) and selenium (Se) concentrations were determined by radiochemical neutron activation analysis in samples from the pituitary glands, occipital cortices, renal cortices, abdominal muscles, and thyroid glands of cadavers. Samples were retrieved from dental staff occupationally exposed to Hg and from the general population. Increased concentrations
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12. Aerobic degradation of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) by Alcaligenes eutrophus A5.
Biotransformation of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) by Alcaligenes eutrophus A5 was demonstrated by analysis of ethyl acetate-extracted products from resting cell cultures. Gas chromatography-mass spectrometry characterization of the neutral extracts revealed two hydroxy-DDT intermediates (m/z = 370) with retention times at 19.55 and 19.