Quasispecies
Mostrando 1-12 de 216 artigos, teses e dissertações.
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1. Evolution of equine influenza viruses (H3N8) during a Brazilian outbreak, 2015
Abstract Equine influenza is one of the major respiratory infectious diseases in horses. An equine influenza virus outbreak was identified in vaccinated and unvaccinated horses in a veterinary school hospital in São Paulo, SP, Brazil, in September 2015. The twelve equine influenza viruses isolated belonged to Florida Clade 1. The hemagglutinin and neuramini
Braz. J. Microbiol.. Publicado em: 2018-06
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2. Caracterização molecular de recombinantes intersubtipos do vírus da imunodeficiência humana tipo 1(HIV-1) em pacientes provenientes da epidemia do estado de São Paulo. / Molecular characterization of recombinant intersubtipos of human immunodeficiency virus type 1 (HIV-1) in patients from the epidemic in the state of Sao Paulo, Brazil.
The extensive HIV-1 genetic diversity has several implications on the viral adaptive and evolutionary capabilities. This diversity is due to intensive mutational rates derived from error-prone activity of viral reverse transcriptase and RNA genomic instability, generating a highly diverse and heterogeneous viral population named quasispecies. However, even t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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3. Simulação Computacional e Análise de um Modelo Fenotípico de Evolução Viral. / Computer Simulation and Analysis of a Phenotypic Model of Viral Evolution
A large amount of viruses of medical importance such as HIV, respiratory syncytial virus, the hepatitis C virus, influenza A (H1N1) and polio virus, has RNA genome. These viruses exhibit extremely high mutational rate, fast replicative kinetics, large population of particles and high genetic diversity. Manifested during the infectious process, these features
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2011
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4. Identificação e caracterização do vírus da imunodeficiência felina de amostras obtidas de felinos mantidos em um abrigo na cidade de São Paulo / Characterization of isolates of FIV from an open shelter in Sao Paulo
O vírus da imunodeficiência felina (FIV) é um lentivirus que infecta gatos domésticos (Felis catus), causando uma imunodeficiência progressiva análoga a AIDS (Síndrome da Imunodeficiência Adquirida Humana). A ampla heterogeneidade molecular do FIV e a alta capacidade de promover mutações sob pressões imunológicas, farmacológicas ou ambientais s�
Publicado em: 2010
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5. Quasispecies detection in human respiratory syncytial virus (HRSV) samples in absence and presence of polyclonal serum / Detecção de quasispecies em amostras de vírus respiratório sincicial humano (HSRV) na ausência e na presença de soros policlonais
Human respiratory syncytial virus (HRSV) is one of the most important clinical respiratory pathogens, since 64 millions children in the world are infected by this agent every year. Host immunity and viral genetic variability are important factors to a vaccine development, besides quasispecies presence in the viral population. In this work, HRSV quasispecies
Publicado em: 2009
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6. Effects of physical exercise on the glutamate receptors expression on the rat brain. / Efeitos do exercicio físico sobre a expressão de receptores de glutamato no encéfalo de ratos.
Este estudo visou observar os efeitos plásticos induzidos pelo exercício a curto prazo em regiões motoras do encéfalo de ratos. Observou-se a expressão das subunidades GluR1 e GluR2/3. Os animais foram divididos em grupos de: 3 dias(COR3), 7 dias(COR7) e 15 dias(COR15); e um grupo controle(CONT). Empregaram-se as técnicas de imuno-histoquímica e immun
Publicado em: 2009
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7. Variabilidade genética do vírus da hepatie [i.e. hepatite] C em pacientes em hemodiálise no Brasil central
A infecção pelo vírus da hepatite C (HCV) ocorre com freqüência elevada em pacientes com insuficiência renal crônica (IRC) em hemodiálise. O objetivo deste estudo foi caracterizar a variabilidade genética do HCV circulante em pacientes em hemodiálise no Brasil Central. Na primeira etapa deste estudo, os genótipos e subtipos do HCV foram identifica
Publicado em: 2009
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8. Viróides e virusóides: relíquias do mundo de RNA
Até meados do século XX, os vírus eram considerados os representantes mais simples da escala biológica. A descoberta dos RNAs satélites e dos viróides por volta de 1970 foi surpreendente, pois comprovou-se a existência de uma nova classe de moléculas auto-replicativas ainda mais simples, denominada agentes sub-virais. Há indícios de que os viróide
Fitopatologia Brasileira. Publicado em: 2006-06
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9. Cooperação e Conflito em Modelos de Vesículas Pré-Bióticas / Cooperation and Conflict in Prebiotic Vesicle Models
The primordial genetic information crisis as defined by the Eigens quasispecies model, which can be used as a paradigm here, has been a challenge to any theory about the origin of life and prebiotic evolution for more than three decades. Despite several tentative solutions proposed along this period, theres no consensual solution to the scientific commun
Publicado em: 2006
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10. Molecular biology and clinical implication of hepatitis C virus
Hepatitis C virus (HCV) was first described in 1989 as the putative viral agent of non-A non-B hepatitis. It is a member of the Flaviviridae family and has been recognized as the major causative agent of chronic liver disease, including chronic active hepatitis, cirrhosis and hepatocellular carcinoma. HCV is a positive RNA virus with a genome containing appr
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-05
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11. CD81 binding regions of hepatitis C virus remain conserved after liver transplantation
CD81 is a surface-associated protein expressed in the membranes of mammalian cells. It has been suggested that CD81 interacts with hepatitis C virus E2 protein, and thus might facilitate the entry of HCV into hepatocytes. The envelope-binding site appears to involve amino acids (aa) 480-493 and 544-551 within the E2 glycoprotein. Little is known about the qu
Brazilian Journal of Infectious Diseases. Publicado em: 2004-04
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12. "Hepatite colestática associada ao vírus da hepatite C pós-transplante hepático: estudo virológico, histopatológico e imuno-histoquímico" / Severe recurrent cholestatic hepatitis after liver transplantation : virological, histological and immuno-histochemical evaluation
Following liver transplantation (OLT) HCV-related disease severity is highly variable, with a minority of cases progressing to an extremely severe form of cholestatic hepatitis, in which the pathogenesis is not yet understood. We aim to compare virological, histological and immunohistological changes in patients developing mild and severe post-OLT HCV recurr
Publicado em: 2004