Quantitative Genetics
Mostrando 1-12 de 163 artigos, teses e dissertações.
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1. Evaluation of the promoter methylation status of hypoxia factor 3A and interleukin-6 genes and expression levels of mir-130b and mir-146b in childhood obesity
SUMMARY OBJECTIVE: Obesity, which causes many serious diseases, is increasing exponentially in childhood across the world. Epigenetic changes, as well as genetics, play an important role in the process of adipogenesis. Therefore, we aimed to examine the expression levels of obesity-related MicroRNA-130b and MicroRNA-146b and the methylation status of hypoxi
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. The study of copy number variations in the regions of PRKAB2 and PPM1K among congenital heart defects patients
RESUMO OBJETIVO: Este estudo teve como objetivo avaliar a associação genética do número de cópias em dois genes (PRKAB2 e PPM1K) localizados em duas regiões (tetralogia de Fallot e comunicação interventricular) em uma população chinesa da etnia Han. METODOLOGIA: Um total de 200 pacientes com doença cardíaca congênita (100 pacientes com tetralo
Rev. Assoc. Med. Bras.. Publicado em: 22/07/2019
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3. Evaluating the current state of the art of Huntington disease research: a scientometric analysis
Huntington disease (HD) is an incurable neurodegenerative disorder caused by a dominant mutation on the 4th chromosome. We aim to present a scientometric analysis of the extant scientific undertakings devoted to better understanding HD. Therefore, a quantitative study was performed to examine the current state-of-the-art approaches that foster researchers’
Braz J Med Biol Res. Publicado em: 11/01/2018
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4. Genomic dissection of inbreeding depression: a gate to new opportunities
ABSTRACT Inbreeding depression, reduction in performance of quantitative traits, including reproduction and survival, caused by inbreeding, is a well-known phenomenon observed in almost all experimental, domesticated, and natural populations. In spite of its importance to the fate of a small population and numerous research performed in the last century, the
R. Bras. Zootec.. Publicado em: 2017-09
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5. Quantitative genetics theory for genomic selection and efficiency of genotypic value prediction in open-pollinated populations
ABSTRACT: Quantitative genetics theory for genomic selection has mainly focused on additive effects. This study presents quantitative genetics theory applied to genomic selection aiming to prove that prediction of genotypic value based on thousands of single nucleotide polymorphisms (SNPs) depends on linkage disequilibrium (LD) between markers and QTLs, assu
Sci. agric. (Piracicaba, Braz.). Publicado em: 2017-02
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6. Quantitative genetics theory for genomic selection and efficiency of breeding value prediction in open-pollinated populations
ABSTRACT To date, the quantitative genetics theory for genomic selection has focused mainly on the relationship between marker and additive variances assuming one marker and one quantitative trait locus (QTL). This study extends the quantitative genetics theory to genomic selection in order to prove that prediction of breeding values based on thousands of si
Sci. agric. (Piracicaba, Braz.). Publicado em: 2016-06
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7. VARIABILIDAD GENÉTICA DE PARENTALES Y POBLACIONES F1 INTER E INTRAESPECÍFICAS DE Physalis peruviana L. Y P. floridana Rydb.
ABSTRACTCape gooseberry, Physalis peruviana, is an Andean fruit of great importance for export markets; its main limitation for production in Colombia is the vascular wilt caused by Fusarium oxysporum. The present study proposed the generation of F1 populations between contrasting pathogen response parents and their evaluation at molecular level to support
Rev. Bras. Frutic.. Publicado em: 2015-03
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8. Efeito do fluoreto no osso de camundongos com diferentes susceptibilidades genéticas à fluorose: uma análise proteômica / Effect of fluoride on bone of mice with different genetic susceptibilities to fluorosis: a proteomic analysis
Genetic factors have been shown to influence bone and enamel responses to fluoride (F), but the molecular mechanisms involved remain unclear. In this study, a label-free proteomics approach was employed to identify and evaluate changes in bone protein expression of two mouse strains with different susceptibilities to fluorosis (A/J a susceptible strain, 129P
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/06/2012
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9. Modelo hierárquico bayesiano na determinação de associação entre marcadores e QTL em uma população F2 / Bayesian hierarchical model in the determination of association between markers and QTL in a F2 population
O objetivo do mapeamento de QTL (Quantitative Trait Loci ) e identificar sua posição no genoma, isto e, identificar em qual cromossomo esta e qual sua localização nesse cromossomo, bem como estimar seus efeitos genéticos. Uma vez que as localizações dos QTL não são conhecidas a priori, marcadores são usados frequentemente para auxiliar no seu mapea
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2012
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10. Caracterização agronômica e seleção de linhagens de soja destinadas ao consumo humano
Soybean is the most important crop to man, because it contains in the grain, about 20% of oil and 40% of protein of low cost of production. Brazil is the second largest world producer of soybeans; however the most of the production is destined for industries of vegetable oil and the exportation in the form of grain. Even reducing the risk of chronic diseases
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2012
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11. Método de Haseman-Elston e suas modificações no estudo de genes controladores de característica quantitativa / Haseman-Elston methodology and modifications on the study genes underlining quantitative trait loci
QTL mapping allows to study loci that play a role in complex traits, as well to determine their chromosomal locations. For this purpose, a set of methods useful for the study of quantitative traits are those based on Haseman-EIston regression, that is quite used in human genetics. These are robustness regression methods for linkage analysis that can be used
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/01/2012
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12. Epistasia para a produção de grãos e caracteres da planta em milho / Epistasis for yield and plant traits in maize
It is known that epistasis may have important effects in the populations dynamics and in the evolutionary process of the species, and that it is involved in manifestation of important biological phenomena, such as overdominance, inbreeding depression and heterosis. However, epistasis is considered one of the more complex aspects of quantitative genetics sinc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/12/2011