Pten
Mostrando 1-12 de 188 artigos, teses e dissertações.
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1. Prevalence of ERG expression and PTEN loss in a Brazilian prostate cancer cohort
PTEN is the most commonly inactivated tumor suppressor gene in primary prostate cancer (PCa) and its loss is associated with poor clinical outcomes. ERG rearrangement is a genomic alteration frequently found in PCa and its prognostic significance has yielded mixed results. Although the association of PTEN and ERG biomarkers has potential impact on clinical o
Braz J Med Biol Res. Publicado em: 05/12/2019
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2. FSH receptor binding inhibitor up-regulates ARID1A and PTEN genes associated with ovarian cancers in mice
Experiments were conducted to determine if the follicle-stimulating hormone (FSH) receptor binding inhibitor (FRBI) impacts the expression levels of AT-rich interactive domain-containing protein 1A (ARID1A) and phosphatase and tensin homolog (PTEN) in ovaries and blood, as well as expressions of follicle-stimulating hormone cognate receptor (FSHR) gene and p
Braz J Med Biol Res. Publicado em: 19/06/2019
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3. Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change
Abstract: Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma,
An. Bras. Dermatol.. Publicado em: 2019-02
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4. Association between decreased expression of estrogen receptor alpha, androgen receptor and phosphatase and tensin homolog immunoexpression in the canine prostate
RESUMO: A glândula prostática canina é um órgão dependente de hormônio, e o desequilíbrio na expressão dos receptores de estrógeno e andrógeno estão diretamente associados com o desenvolvimento de diferentes doenças. Devido à falta de informação sobre o comportamento desses receptores no câncer prostático canino (PC), este estudo tem por obj
Pesq. Vet. Bras.. Publicado em: 2019-01
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5. The role of Phosphatidylinositol 3 kinase (PI3K) and Cycloxygenase-2 (COX2) in carcinogenesis of colorectal polyps
RESUMO Objetivos: Determinar a expressão imuno-histoquímica de Fosfatase homóloga a tensina (PTEN), Fosfatidilinositol-3-cinase (PI3K), Ciclooxigenase-2 (COX2) e um marcador de proliferação (Ki67) em pólipos colorretais e correlacionar com dados clínicos e patológicos buscando sua correspondência na carcinogênese. Métodos: Revisados 297 pólipos
J. Coloproctol. (Rio J.). Publicado em: 2018-03
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6. Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LPS)-induced apoptosis and inflammation in human renal tubular epithelial cells, and to evaluate the potential r
Braz J Med Biol Res. Publicado em: 11/12/2017
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7. Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells
Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including tumor invasion, metastasis, and drug resistance. In this stu
Braz J Med Biol Res. Publicado em: 13/11/2017
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8. Análise imuno-histoquímica da apoptose e proliferação celular em pulmões de prematuros com doença pulmonar crônica (displasia broncopulmonar)
RESUMO Introdução: A fisiopatologia da doença pulmonar crônica, clinicamente conhecida como displasia broncopulmonar (DBP), ainda é incerta. Acredita-se que mecanismos de proteção, como liberação de mediadores inflamatórios e ativação de processos apoptóticos e/ou proliferativos, são acionados no tecido pulmonar de prematuros na tentativa de r
J. Bras. Patol. Med. Lab.. Publicado em: 2016-12
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9. Modelagem molecular proteica dos marcadores genéticos do câncer de tireoide
RESUMO Introdução: Os avanços nos estudos de biologia molecular da tireoide não fornecem apenas uma visão sobre as doenças tireoidianas, mas um diagnóstico preciso do câncer de tireoide. Objetivo: Realizar um tutorial sobre modelagem molecular proteica dos marcadores genéticos do câncer de tireoide. Métodos: As proteínas foram selecionadas uti
J. Bras. Patol. Med. Lab.. Publicado em: 2016-10
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10. Potential therapeutic strategies for non - muscle invasive bladder cancer based on association of intravesical immunotherapy with P-MAPA and systemic administration of cisplatin and doxorubicin
ABSTRACT The present study describes the histopathological and molecular effects of P-MAPA (Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride) intravesical immunotherapy combined with systemic doxorubicin or cisplatin for treatment of non-muscle invasive bladder cancer (NMIBC) in an appropriate animal model. Our results showed an u
Int. braz j urol.. Publicado em: 2016-10
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11. Mir-190b negatively contributes to the Trypanosoma cruzi- infected cell survival by repressing PTEN protein expression
Chagas disease, which is caused by the intracellular protozoanTrypanosoma cruzi, is a serious health problem in Latin America. The heart is one of the major organs affected by this parasitic infection. The pathogenesis of tissue remodelling, particularly regarding cardiomyocyte behaviour after parasite infection, and the molecular mechanisms that occur immed
Mem. Inst. Oswaldo Cruz. Publicado em: 2015-12
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12. Concurrent Down-Regulation of PTEN and NKX3.1 Expression in Iranian Patients with Prostate Cancer
ABSTRACT NKX3.1 and PTEN genes are involved in the development and progression of prostate cancer (PCa). Here, in line with other studies that correlated the expression of these two genes, we aimed at evaluating the expression pattern of these genes in clinical PCa samples. Collectively, 81 tissue samples including 45 human PCa and 36 benign prostatic hyperp
Int. braz j urol.. Publicado em: 2015-10