Prostanoids
Mostrando 1-12 de 75 artigos, teses e dissertações.
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1. The Relationship between Serum Ischemia-Modified Albumin Levels and Uterine Artery Doppler Parameters in Patients with Primary Dysmenorrhea
Abstract Objective Primary dysmenorrhea occurs due to abnormal levels of prostanoids, uterine contractions, and uterine blood flow. However, the reasons for pain in primary dysmenorrhea have not yet been clarified. We examined the blood flow alterations in patients with primary dysmenorrhea and determined the relationship between ischemia-modified albumin (
Rev. Bras. Ginecol. Obstet.. Publicado em: 2020-10
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2. Eicosanoids and cancer
Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and inflammatory responses. In recent years, studies have shown the importance of eicosanoids in the control of physiol
Clinics. Publicado em: 09/08/2018
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3. Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
Background: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weigh
Braz. J. Phys. Ther.. Publicado em: 12/06/2015
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4. Cellular and molecular studies of the effects of a selective COX-2 inhibitor celecoxib in the cardiac cell line H9c2 and their correlation with death mechanisms
Cardiovascular disease is one of the leading causes of death worldwide, and evidence indicates a correlation between the inflammatory process and cardiac dysfunction. Selective inhibitors of cyclooxygenase-2 (COX-2) enzyme are not recommended for long-term use because of potentially severe side effects to the heart. Considering this and the frequent prescrib
Braz J Med Biol Res. Publicado em: 29/11/2013
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5. Maternal serum progesterone, estradiol and estriol levels in successful dinoprostone-induced labor
Hormone-mediated quiescence involves the maintenance of a decreased inflammatory responsiveness. However, no study has investigated whether labor induction with prostanoids is associated with changes in the levels of maternal serum hormones. The objective of this study was to determine whether labor induction with dinoprostone is associated with changes in m
Braz J Med Biol Res. Publicado em: 11/01/2013
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6. Caracterização funcional e estrutural de uma nova fosfolipase A2 ácida de Bothrops moojeni / Functional and structural characterization of a new acidic phospholipase A2 from Bothrops moojeni
The phospholipase A2 (PLA2s) are enzymes that induce various pharmacological effects and usually correspond to a higher percentage of the protein content of snake venoms. Thus, isolation, biochemical, functional and structural characterization of PLA2s may generate important information for a better understanding of the pharmacological effects and toxicity i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/01/2012
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7. Consequências dos tratamentos realizados com celecoxibe, -tocoferol ou losartan sobre a reatividade em carótidas de ratos submetidos à lesão com cateter balão / Consequences of the treatments performed with celecoxib, -tocopherol or losartan on the carotid of reactivity in rats subjected to injury with balloon catheter.
The injury by balloon catheter is a procedure commonly used to study the mechanisms of restenosis. The mechanical stress produced by the passage of the balloon promotes changes both in the injured artery in the contralateral artery. There was an increased density of neurons containing neuropeptides such as substance P (SP) and the Gene Related Peptide of Cal
Publicado em: 2009
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8. Biochemical and functional studies of twenty sildenafil analogues in human platelets and in the rabbit corpus cavernosum and aorta / Estudos funcionais e bioquimicos de vinte analogos do sildenafil em plaquetas humanas, corpo cavernoso e aorta de coelho
Sildenafil, a cGMP-specific phosphodiesterase-5 (PDE5) inhibitor, is used for the treatment of erectile dysfunction. In the search for a potent and selective PDE5 inhibitor, new sildenafil analogues (6a-v), characterized by the presence on the sulphonyl group in the 5 position of novel N-4-substituted piperazines or ethylenediamine moiety, were synthesized.
Publicado em: 2008
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9. Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta
Previous studies have shown that the vascular reactivity of the mouse aorta differs substantially from that of the rat aorta in response to several agonists such as angiotensin II, endothelin-1 and isoproterenol. However, no information is available about the agonists bradykinin (BK) and DesArg9BK (DBK). Our aim was to determine the potential expression of k
Brazilian Journal of Medical and Biological Research. Publicado em: 14/03/2007
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10. Prostanoids modulate inflammation and alloimmune responses during graft rejection
Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allog
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-12
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11. Ionic radiocontrast inhibits endothelium-dependent vasodilation of the canine renal artery in vitro: possible mechanism of renal failure following contrast medium infusion
To determine if radiocontrast impairs vascular relaxation of the renal artery, segments (4-5 mm in length) of canine renal artery were suspended in vitro in organ chambers to measure isometric force (95% O2/5% CO2, at 37ºC). Arterial segments with and without endothelium were placed at the optimal point of their length-tension relation and incubated with 10
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-02
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12. Vascular reactivity of isolated aorta of late pregnant rats: role of nitric oxide and prostaglandins. / "Reatividade vascular de aortas isoladas de ratas ao término da gestação: participação de óxido nítrico e prostanóides"
Late pregnancy is associated with diminished reactivity to vasoconstrictor agents that may be mediated by altered production/release of nitric oxide (NO) and prostaglandins. In the present study the role of NO synthase (NOS) and cyclooxygenase (COX) derived products in the altered vascular reactivity to phenylephrine (PE) was investigated in the isolated aor
Publicado em: 2004