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Mostrando 13-18 de 18 artigos, teses e dissertações.
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13. Use of second-site suppressor mutations in Drosophila to identify components of the transcriptional machinery.
Isolation of second-site suppressor mutations provides a powerful method for identifying (i) genes that encode proteins that interact and (ii) domains within the interacting proteins that contact each other. Flies conditionally lethal because they carry mutations in the largest subunit of RNA polymerase II were mutagenized; ten million progeny were then scre
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14. Experimental induction of premature movement of rat palatal shelves in vivo.
In order to enhance further knowledge of palatal shelf movement and the factors involved in palate closure, a method was developed for prematurely elevating palatal shelves in utero. Approximately 7 hours before expected shelf elevation, pregnant Sprague-Dawley rats were laparotomized and two medially directed squeezes were applied to the face of some of the
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15. Targeting transforming growth factor α expression to discrete loci of the neuroendocrine brain induces female sexual precocity
Precocious puberty of cerebral origin is a poorly understood disorder of human sexual development, brought about by the premature activation of those neurons that produce luteinizing hormone-releasing hormone (LHRH), the neuropeptide controlling sexual maturation. An increased production of transforming growth factor α (TGFα) in the hypothalamus has been i
The National Academy of Sciences of the USA.
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16. Functional Genetic Screen for Genes Involved in Senescence: Role of Tid1, a Homologue of the Drosophila Tumor Suppressor l(2)tid, in Senescence and Cell Survival
We performed a genetic suppressor element screen to identify genes whose inhibition bypasses cellular senescence. A normalized library of fragmented cDNAs was used to select for elements that promote immortalization of rat embryo fibroblasts. Fragments isolated by the screen include those with homology to genes that function in intracellular signaling, cellu
American Society for Microbiology.
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17. Genes of Bacillus cereus and Bacillus anthracis Encoding Proteins of the Exosporium
The exosporium is the outermost layer of spores of Bacillus cereus and its close relatives Bacillus anthracis and Bacillus thuringiensis. For these pathogens, it represents the surface layer that makes initial contact with the host. To date, only the BclA glycoprotein has been described as a component of the exosporium; this paper defines 10 more tightly ass
American Society for Microbiology.
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18. Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants
Various gram-negative animal and plant pathogens use a novel, sec-independent protein secretion system as a basic virulence mechanism. It is becoming increasingly clear that these so-called type III secretion systems inject (translocate) proteins into the cytosol of eukaryotic cells, where the translocated proteins facilitate bacterial pathogenesis by specif
American Society for Microbiology.