Potency For Action
Mostrando 1-12 de 201 artigos, teses e dissertações.
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1. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity
ABSTRACT Combination therapy drugs are considered a fundamental way to control malaria as it mimimizes the risk of emergence of resistance to the individual partner drugs. Consequently, this type of therapy constitutes a driving force for the discovery of new drugs with different modes of action, since this will provide options for combining different drugs
An. Acad. Bras. Ciênc.. Publicado em: 21/05/2018
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2. The immunogenicity and anti-tumor effects of a lung cancer DNA vaccine harboring a MUC-1 and GM-CSF fusion gene
ABSTRACT DNA vaccines have been shown to be an effective approach to induce antigen-specific cellular and humoral immunity. However, the inability of DNA vaccines to elicit strong immune responses in clinical trials limits the application of DNA vaccines. Here, we developed a new DNA vaccine based on MUC1, which has been suggested as a potential target for l
Braz. arch. biol. technol.. Publicado em: 27/06/2016
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3. Modelagem molecular de uma série de compostos inibidores da enzima integrase do vírus HIV-1 / Molecular modelling for a series of integrase HIV-I inhibitors
An essential step in the HIV life cycle is integration of the viral DNA into the host chromosome. This step is catalyzed by a 32-kDa viral enzyme HIV integrase (IN). HIV-1 IN is an important and validated target, and the drugs that selectively inhibit this enzyme, when used in combination with reverse transcriptase (RT) and protease (PR) inhibitors, are beli
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/07/2011
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4. Study of natural products and synthetic derivatives searching specific inhibitors of cathepsins L and V / Estudo de produtos naturais e derivados sintéticos buscando inibidores seletivos das catepsinas L e V
The present work describes the search of bioactive secondary metabolites in plant species of genus Zanthoxylum and synthetic derivatives seeking specific inhibitors of cathepsins L and V. The natural products are involved in approximately 50% of all drugs marketed. Cathepsins represent a class of enzymes that has the primary function of randomly degrade prot
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/01/2011
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5. EFFECT OF AQUEOUS FRACTION OF LEAVES DE COSTUS SPIRALIS (JACQ.) ROSCOE CONTRACTILE FUNCTION ON HEART MAMMALS. / EFEITO DA FRAÇÃO AQUOSA DAS FOLHAS DE COSTUS SPIRALIS (JACQ.) ROSCOE SOBRE A FUNÇÃO CONTRÁTIL DO CORAÇÃO DE MAMÍFEROS.
Teas and infusions from C. spiralis leaf have largely been used by folk medicine as diuretic, hypotensor, cytotoxic, immunomodulator, antilithiasic, antidiarrheic, antispasmodic, antiurolitic, antimicrobian, antifungic, antioxidant, antileishmania activity, antiinflamatory, and antiedematogenic activity. In spite of these biological effects attributed to the
Publicado em: 2011
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6. Ergosterol biosynthesis and drug development for Chagas disease
This article presents an overview of the currently available drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors (EBI). These compounds are currently the most advanced can
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
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7. Tratamento neonatal com agonista 5-HT1A: repercussÃes sobre o desenvolvimento da atividade locomotora em ratos
Locomotion is an important function to living beings. Environmental changes that occur during the critical period of development can promote changes in the development of locomotor activity, bringing impairment for the individual. Works using automatic analysis of behavior are of great importance for the study of locomotion. Among the systems that can influe
Publicado em: 2009
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8. Das imagens identitarias da pedagogia ao oficio de pedagogo : traçados nomades / From the identitary images in pedagogy to the work of the work of the tachers : nomadic traces
The object of this study is to relocate the problematic of teacher/pedagogue and Pedagogy identity in the contemporary times, according to the latest analytical basis. Na investigative, reflexive, conceptual and immanent methodology will be used, based on the philosophy of Gilles Deleuze and Félix Guattari, and it does not disconsider the practical nature o
Publicado em: 2009
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9. Efeitos do eugenol sobre variáveis elétricas de neurônios do gânglio cervical superior de ratos. / Effects of eugenol on electrical parameters of neurons superior cervical ganglion of rats.
Eugenol (EUG) is a fenilpropanoid obtained from the essential oils of plants such as clove and basil which has widespread use in dentistry on the sealing of the dental root cavity. EUG possesses, amongst others, an analgesic effect that may be due to a local anesthetic like inhibition of sodium currents, to a capsaicin like activation of TRPV-1 receptors or
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/12/2008
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10. Vejo um museu de grandes novidades, o tempo nÃo para ... sociopoetizando o museu e musealizando a vida. / I see a museum of great news, not the time to ... sociopoetizando the museum and musealizando life
This label has an analysis of an investigative process that has the purpose to study the relation between the museum and the population in an Popular Education perspective and the new museum, through a discover of some conceptions that the community do about the word museum. For this, it was optioned to an optional collective âSociopoeticoâ research, that
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/11/2008
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11. Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente
Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with th
Química Nova. Publicado em: 2008
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12. Educação Ambiental na Escola Pública: sua contribuição ao processo de construção participativa de uma cultura emancipatória
The present dissertation is a study about an intervention in Environmental Education (EE), developed between March 2004 and May 2007, in a public school named Escola Classe Céu Azul, in Brasília, Distrito Federal (Federal District, Brazil), which offers 1st to 4th grades. The aim of this research was to analyze the educational intervention process proposed
Publicado em: 2008