Potassium Channels
Mostrando 13-24 de 767 artigos, teses e dissertações.
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13. Novo método de fracionamento da peçonha do escorpião Tityus serrulatus e caracterização eletrofisiológica das toxinas Ts6 e Ts7 / New fractionation procedure of Tityus serrulatus venom and electrophysiological characterization of toxins Ts6 and Ts7
In Brazil, Tityus serrulatus (Ts) species is the responsible for the most scorpion accidents and also for the major incidence of accidents caused by venomous animals. About 16 different toxins of Ts venom have been listed so far, being Ts1 the major one. Among these toxins, the neurotoxins with action on sodium and potassium channels are the most interest in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/06/2012
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14. Participação dos canais de potássio no efeito relaxante do ácido ent-7a-hidroxitraquiloban-18-oico em traqueia isolada de cobaia / Participation of potassium channels in the ent-7a-hidroxitrachyloban-18-oic acid relaxation effect on guinea pig trachea
From Xylopia langsdorfiana A. St-Hil. &Tul. stem bark was isolated the diterpene of trachylobane class, ent-7α-hydroxytrachyloban-18-oic acid (trachylobane-318) that in previous studies showed to be able to relax guinea-pig trachea pre-contracted by carbachol (CCh). Thus, we aimed to investigate the action mechanism underlying in this trachylobane-318 r
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2012
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15. Participação dos canais para potássio nos efeitos cardiovasculares induzidos por um novo composto 1,3,4- oxadiazol. / Participation of potassium channels in cardiovascular effects induced by a novel compound 1,3,4-oxadiazole.
Os efeitos farmacológicos de OXDINH, um derivado 1,3,4-oxadiazol obtido por síntese orgânica, sobre o sistema cardiovascular e a participação dos canais para K+ nesta resposta, foram estudados em ratos usando técnicas combinadas in vivo e in vitro. Em anéis de artéria mesentérica superior isolada de rato, com endotélio funcional, OXDINH (10-10 10-4
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/02/2012
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16. Identification of mechanisms involved in the relaxation of rabbit cavernous smooth muscle by a new nitric oxide donor ruthenium compound
PURPOSE: The aim of this study was to evaluate the relaxation in vitro of cavernous smooth muscle induced by a new NO donor of the complex nitrosil-ruthenium, named trans-[Ru(NH3)4(caffeine)(NO)]C13 (Rut-Caf) and sodium nitroprusside (SNP). MATERIALS AND METHODS: The tissues, immersed in isolated bath systems, were pre-contracted with phenilephrine (PE) (1 �
Int. braz j urol.. Publicado em: 2012-10
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17. Pharmacological effects of the sesquiterpenic alcohol (-)-α-bisabolol in vascular and non-vascular smooth muscle preparations. / Efeitos farmacolÃgicos do Ãlcool sesquiterpÃnico (-)-α-bisabolol em preparaÃÃes isoladas de mÃsculo liso vasculares e nÃo-vasculares.
In this in vitro study the effects of the monocyclic sesquiterpene alcohol (-)-α-bisabolol on the contractile behavior of rat and mouse smooth muscle preparations were investigated. Under resting tonus, (-)-α-bisabolol relaxed duodenal smooth muscle preparations, whereas it showed biphasic effects in other smooth muscles, contracting endothelium-in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011
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18. STUDY OF SODIUM AND POTASSIUM ION CHANNELS VIA STOCHASTIC DYNAMIC / ESTUDO DOS CANAIS IÔNICOS DE SÓDIO E POTÁSSIOVIA DINÂMICA ESTOCÁSTICA
O presente trabalho apresenta uma revisão sobre os Canais Iônicos de Sódio e de Potássio fazendo uma relacão com os aspectos biofísicos, computacionais e matemáticos. Estudamos os canais iônicos, sob o ponto de vista da Mecânica Estatìstica, mais precisamente, considerando os canais iônicos como um processo markoviano. O objetivo principal deste t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/04/2011
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19. Gynura procumbens Merr. decreases blood pressure in rats by vasodilatation via inhibition of calcium channels
INTRODUCTION: Gynura procumbens has been shown to decrease blood pressure via inhibition of the angiotensinconverting enzyme. However, other mechanisms that may contribute to the hypotensive effect have not been studied. OBJECTIVES: To investigate the cardiovascular effects of a butanolic fraction of Gynura procumbens in rats. METHODS: Anaesthetized rats wer
Clinics. Publicado em: 2011
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20. Effect of glibenclamide on antinociceptive effects of antidepressants of different classes
OBJECTIVES: The purpose of this work was to determine whether the intraperitoneal administration of glibenclamide as a K ATP channel blocker could have an effect on the antinociceptive effects of antidepressants with different mechanisms of action. METHODS: Three antidepressant drugs, amitriptyline as a dual-action, nonselective inhibitor of noradrenaline an
Clinics. Publicado em: 2011
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21. EFFECT OF AQUEOUS FRACTION OF LEAVES DE COSTUS SPIRALIS (JACQ.) ROSCOE CONTRACTILE FUNCTION ON HEART MAMMALS. / EFEITO DA FRAÇÃO AQUOSA DAS FOLHAS DE COSTUS SPIRALIS (JACQ.) ROSCOE SOBRE A FUNÇÃO CONTRÁTIL DO CORAÇÃO DE MAMÍFEROS.
Teas and infusions from C. spiralis leaf have largely been used by folk medicine as diuretic, hypotensor, cytotoxic, immunomodulator, antilithiasic, antidiarrheic, antispasmodic, antiurolitic, antimicrobian, antifungic, antioxidant, antileishmania activity, antiinflamatory, and antiedematogenic activity. In spite of these biological effects attributed to the
Publicado em: 2011
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22. Estudo das propriedades antiespasmÃdicas e miorrelaxantes do Ãleo essencial de Ocimum Micranthum em traquÃias isoladas de ratos wistar. / ANTISPASMODIC AND MYORELAXANTS PROPRIETIES OF ESSENTIAL OIL OF OCIMUM MICRANTHUM IN ISOLATED TRACHEA OF WISTAR RATS.
The Ocimum. micranthum Willd. is a plant popularly known as âalfavaca-de-folha-miÃdaâ or âestoraqueâ and is used in folk medicine to treat flu, colds, fever, cough, bronchitis, stomach and intestinal infections, ear infections and as stimulant and carminative. This study aimed to show the activity of its essential oil (EOOM) and of its main constituent,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2010
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23. Avaliação dos efeitos induzidos pelo 2-Nitrato-1, 3-Dibutoxipropano (NDBP) sobre o sistema cardiovascular de ratos normotensos - abordagens en vivo e in vitro
Organic nitrates are nitric oxide (NO) donors used in the treatment of cardiovascular diseases mimicking the role of endogenous NO. This study evaluated organic nitrates newly synthesized from glycerin, which cardiovascular actions had not yet been investigated. Therefore, the cardiovascular effects produced by organic nitrates derived from glycerin: 2-nitra
Publicado em: 2010
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24. EFEITOS DO TREINAMENTO RESISTIDO SOBRE AS ALTERAÇÕES NA REATIVIDADE VASCULAR DE RATOS DIABÉTICOS INDUZIDOS POR ALOXANO. / EFFECTS OF RESISTANCE TRAINING ON CHANGES IN VASCULAR REACTIVITY OF DIABETIC RATS INDUCED BY ALLOXAN.
Diabetes mellitus (DM) is presented as a metabolic disorder characterized by chronic hyperglycemia that is associated with endothelial dysfunction (ED). Among the various therapies employed in the improvement of ED, primary prevention, which includes changes in diet and physical training (PT), has been the right one. This study evaluated the effects of resis
Publicado em: 2010