Estudo das propriedades antiespasmÃdicas e miorrelaxantes do Ãleo essencial de Ocimum Micranthum em traquÃias isoladas de ratos wistar. / ANTISPASMODIC AND MYORELAXANTS PROPRIETIES OF ESSENTIAL OIL OF OCIMUM MICRANTHUM IN ISOLATED TRACHEA OF WISTAR RATS.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

02/08/2010

RESUMO

The Ocimum. micranthum Willd. is a plant popularly known as âalfavaca-de-folha-miÃdaâ or âestoraqueâ and is used in folk medicine to treat flu, colds, fever, cough, bronchitis, stomach and intestinal infections, ear infections and as stimulant and carminative. This study aimed to show the activity of its essential oil (EOOM) and of its main constituent, methyl cinnamate, in rat isolated trachea. It was shown that both the OEOM and methyl cinnamate (1-1000 Âg/mL) did not change the basal tone, but they were able to reverse the contractile response induced by potassium chloride or carbachol with IC50 of 112 and 128.2 Âg/mL (for EOOM) and 308 and 100 μg/mL (for methyl cinnamate), respectively. At 100 Âg/mL, added before the contractile agent, EOOM attenuated maximal response to KCl in trachea from naÃve rats. This effect did not occur when contraction was induced by carbachol in the presence of nitrendipine. Additionally, in animals subjected to an ovalbumin-sensitized model of asthma, EOOM was more active in challenged than in sensitized animals. In conclusion,th e myorelaxant and antispasmodic effects of the EOOM are due to its preferential action on voltage-operated calcium channels. Its major constituent, methyl cinnamte, appears to be involved in the pharmacological effects of the EOOM.

ASSUNTO(S)

farmacologia plantas medicinais Ãleos vegetais ocimum plants medicinal plant oils ocimum

ACESSO AO ARTIGO

Documentos Relacionados