Polymyxins
Mostrando 1-12 de 36 artigos, teses e dissertações.
-
1. Drug-induced nephrotoxicity
RESUMO A lesão renal aguda é um diagnóstico muito comum, presente em até 60% dos pacientes críticos, e sua terceira maior causa é a toxicidade de medicamentos. A nefrotoxicidade pode ser definida como qualquer lesão renal causada por medicamentos, direta ou indiretamente, tendo a insuficiência renal aguda, tubulopatias e glomerulopatias como apresent
Rev. Assoc. Med. Bras.. Publicado em: 13/01/2020
-
2. Multidrug-resistant Klebsiella pneumoniae: genetic diversity, mechanisms of resistance to polymyxins and clinical outcomes in a tertiary teaching hospital in Brazil
ABSTRACT Increased resistance to polymyxin in Klebsiella pneumoniae (ColRKP) has been observed. Molecular epidemiology, as well as the clinical impact of these difficult to treat pathogens need to be better characterized. We present the clinical outcomes of 28 patients infected by ColRKP in a tertiary hospital. Isolates with MIC >2 by Vitek 2 were confirmed
Rev. Inst. Med. trop. S. Paulo. Publicado em: 19/06/2019
-
3. Non-clonal occurrence of pmrB mutations associated with polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae in Brazil
BACKGROUND Polymyxins are currently used as a “last-line” treatment for multidrug-resistant Gram-negative infections. OBJECTIVES To identify the major mechanisms of resistance to polymyxin and compare the genetic similarity between multi-drug resistant Klebsiella pneumoniae strains recovered from inpatients of public hospitals in the Mid-West of Braz
Mem. Inst. Oswaldo Cruz. Publicado em: 20/05/2019
-
4. Draft genome sequence of a GES-5-producing Serratia marcescens isolated in southern Brazil
Abstract Serratia marcescens is a Gram-negative rod intrinsically resistant to polymyxins and usually associated with wound, respiratory and urinary tract infections. The whole genome of the first GES-5-producing S. marcescens isolated from a Brazilian patient was sequenced using Ion Torrent PGM System. Besides blaGES-5, we were able to identify genes encodi
Braz. J. Microbiol.. Publicado em: 2017-06
-
5. Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on β-lactams and polymyxins
ABSTRACT During the last 30 years there has been a dissemination of plasmid-mediated β-lactamases in Enterobacteriaceae in Brazil. Extended spectrum β-lactamases (ESBL) are widely disseminated in the hospital setting and are detected in a lower frequency in the community setting. Cefotaximases are the most frequently detected ESBL type and Klebsiella pneum
Braz. J. Microbiol.. Publicado em: 2016-12
-
6. Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae
INTRODUCTION:Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection.METHODS: We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae.RESULTS: Three patients were hospitalized in adjacent wards, and two we
Rev. Soc. Bras. Med. Trop.. Publicado em: 26/06/2015
-
7. Efficacy of polymyxins in the treatment of carbapenem-resistant Enterobacteriaceae infections: a systematic review and meta-analysis
In recent years, carbapenem-resistant Enterobacteriaceae has become endemic in many countries. Because of limited treatment options, the abandoned "old antibiotics", polymyxins, have been reintroduced to the clinic. To evaluate the clinical efficacy of polymyxins in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae , we systemica
Braz J Infect Dis. Publicado em: 2015-04
-
8. Influência dos Métodos de Sensibilidade aos Antimicrobianos no Uso Clínico das Polimixinas. / Influence of the Antimicrobial Susceptibility Methods in the Clinical Use of Polymyxins.
Introdução: Acinetobacter spp. e Pseudomonas aeruginosa constituem importantes patógenos causadores de infecções relacionadas à assistência à saúde em hospitais brasileiros e tem se tornado, cada vez mais, resistentes a praticamente todos os antimicrobianos disponíveis. Dessa forma, a indicação clínica do uso parenteral das polimixinas tem sido
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/05/2010
-
9. Uso de polimixina em pacientes submetidos a transplante: Avaliação de eficácia e nefrotoxicidade. / Use of parenteral polymyxins in transplanted patients: Evaluation of efficacy and nephrotoxicity.
Introdução: As polimixinas são antimicrobianos antigos, e que caíram em desuso por muitos anos pelos relatos de toxicidade, principalmente nefrotoxicidade e neurotoxicidade. O surgimento de bactérias gram negativas multirresistentes em especial P aeruginosa e A baumanii em todo o mundo é uma realidade e temos observado seu crescimento em inquéritos ep
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/08/2009
-
10. Tratamento de infecções causadas por Acinetobacter spp. resistente a carbapenem / Treatment of infections caused by multi-drug resistant Acinetobacter spp.
Acinetobacter spp. is a cause of a number of infections, mainly in the ICU setting. Antimicrobials drugs frequently reported as active against Acinetobacter spp include carbapenems, colistin, ampicillin/sulbactam, amikacin, rifampin and tetracyclines and currently carbapenens are considered the main antimicrobial treatment. Unfortunately, over the past years
Publicado em: 2008
-
11. Polymyxins as inhibitors of polyclonal B-cell activators in murine lymphocyte cultures.
The polymyxin antibiotics polymyxin B sulfate and colistin methane sulfonate were examined for their ability to inhibit responses to the polyclonal B-cell activators (PBA) bacterial lipopolysaccharide (LPS), dextran sulfate (DS), pneumococcal polysaccharide (SIII), and purified protein derivative of tuberculin (PPD) in spleen cell cultures. Polymyxin concent
-
12. Interactions of Bacterial Cationic Peptide Antibiotics with Outer and Cytoplasmic Membranes of Pseudomonas aeruginosa
Polymyxins B and E1 and gramicidin S are bacterium-derived cationic antimicrobial peptides. The polymyxins were more potent than gramicidin S against Pseudomonas aeruginosa, with MICs of 0.125 to 0.25 and 8 μg/ml, respectively. These peptides differed in their affinities for binding to lipopolysaccharide, but all were able to permeabilize the outer membrane
American Society for Microbiology.