Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae

AUTOR(ES)

Gaspar, Gilberto Gambero, Bellissimo-Rodrigues, Fernando, Andrade, Leonardo Neves de, Darini, Ana Lúcia, Martinez, Roberto

FONTE

Rev. Soc. Bras. Med. Trop.

DATA DE PUBLICAÇÃO

26/06/2015

RESUMO

INTRODUCTION:Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection.METHODS: We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae.RESULTS: Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae.CONCLUSIONS: Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms.

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