Plga
Mostrando 1-12 de 134 artigos, teses e dissertações.
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1. Carboplatin-loaded surface modified-PLGA nanoparticles confer sustained inhibitory effect against retinoblastoma cell in vitro
RESUMO Objetivo: Investigar o efeito antiproliferativo de poli (lactídeo-coglicolídeo) com superfície modificada carregada com carboplatina contra células de retinoblastoma. Métodos: Preparou-se poli (lactídeo-co-glicolídeo) carregado com carboplatina com ou sem alginato de sódio para modifição da superfície, poli com alginato de sódio (lactíd
Arquivos Brasileiros de Oftalmologia. Publicado em: 2022
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2. Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation
Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this study, tadalafil was prepared and loaded into biodegrad
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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3. Desgaste y corrosión de recubrimientos de PLGA sobre titanio en contacto con hueso y fluido sinovial
ABSTRACT In this work, the synergism between wear and corrosion was evaluated in titanium specimens covered by PLGA. The tests were carried out in a tribocorrosion machine, taking into account two variables: scratch ve-locity and applied load. A bipotentiostat was adapted to obtain the potentiostatic curves and Tafel in resting, moving and wear-corrosion con
Matéria (Rio J.). Publicado em: 16/09/2019
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4. Obtenção de scaffolds bioabsorvíveis a partir de blenda de PLGA e IR com adição de hidroxiapatita
RESUMO A obtenção de scaffolds bioativos a partir da blenda polimérica de poli (ácido láctico-co-glicólico) (PLGA) e poliisopreno (IR) com diferentes adições de Hidroxiapatita (HAp) é proposta como uma alternativa à engenharia de tecidos. Para o preparo das soluções poliméricas, a blenda de PLGA/IR e a HAp foram dissolvidas em clorofórmio. Post
Matéria (Rio J.). Publicado em: 16/09/2019
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5. Study on influence of polymer and surfactant on in vitro performance of biodegradable aqueous-core nanocapsules of tenofovirdisoproxil fumarate by response surface methodology
The major objective of this study was to investigate the effect of biodegradable polymer type and surfactant concentration on various characteristics viz. particle size, entrapment efficiency and drug release rate constant of aqueous core nanocapsules (ACNs) containing tenofovirdisoproxil fumarate. In this study, the nanocapsules were prepared by modified mu
Braz. J. Pharm. Sci.. Publicado em: 12/08/2019
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6. SYNTHESIS, CHARACTERIZATION AND in vitro CYTOTOXICITY OF Acacia mearnsii PROANTHOCYANIDIN LOADED PLGA MICROPARTICLES
ABSTRACT One of the highlighted areas in the development of new materials is the generation of micro- and nanoparticles as drug carriers which allow the progress in formulations with the ability to release active agents in a controlled way. The proanthocyanidins (PAC) extracted from the bark of the Black Wattle have stood out for their biological activities.
Braz. J. Chem. Eng.. Publicado em: 15/07/2019
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7. CELL growth and viability analysis in poli membranes (L-lactic acid-CO-glycolic acid): an in vitro study
RESUMO Objetivo: Esse trabalho avaliou, in vitro, os efeitos biológicos no crescimento e viabilidade celular de fibroblastos em membranas de PLGA com e sem sinvastatina. Materiais e métodos: Foram utilizados dois grupos de membranas reabsorvíveis de polímeros sintéticos: PLGA com sinvastantina e sem sinvastantina, recortadas em formato apropriado para
RGO, Rev. Gaúch. Odontol.. Publicado em: 13/06/2019
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8. Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide
In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The structure of the synthesized polymers was confirmed by FTIR and 1H
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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9. BONEFILL ® block as alternative for bone substitute: a toxicological evaluation
ABSTRACT Bone substitutes based on hydroxyapatite (HA) and Bonefill® (BO - inorganic bovine bone) associated with poly(lactic-co-glycolic acid) (PLGA) (HA/PLGA and BO/PLGA) were evaluated concerning cytotoxicity, genotoxicity and mutagenicity as potential candidates for bone repair. The materials were developed and provided by Bionnovation Biomedical Produc
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
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10. In Vitro and In Vivo Biocompatibility Of ReOss® in Powder and Putty Configurations
Resumo Este estudo avaliou comparativamente duas configurações (pó e massa) de um biomaterial composto com base de PLGA (Poli(láctico-co-glicólico)/hidroxiapatita em nanoescala (ReOss®, Intra-Lock International) através da morfologia microscópica, citotoxicidade in vitro, biocompatibilidade e resposta in vivo como substituto ósseo. MEV e EDS caracte
Braz. Dent. J.. Publicado em: 2018-03
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11. Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA
Mat. Res.. Publicado em: 15/02/2018
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12. Development of VEGF-loaded PLGA matrices in association with mesenchymal stem cells for tissue engineering
The association of bioactive molecules, such as vascular endothelial growth factor (VEGF), with nanofibers facilitates their controlled release, which could contribute to cellular migration and differentiation in tissue regeneration. In this research, the influence of their incorporation on a polylactic-co-glycolic acid (PLGA) scaffold produced by electrospi
Braz J Med Biol Res. Publicado em: 07/08/2017