Pituitary Tumor
Mostrando 25-36 de 208 artigos, teses e dissertações.
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25. PROP1 and CTNNB1 expression in adamantinomatous craniopharyngiomas with or without β-catenin mutations
INTRODUCTION: Activating mutations in exon 3 of the β-catenin gene are involved in the pathogenesis of adamantinomatous craniopharyngiomas. Recently, the interaction between β-catenin and PROP1 has been shown to be responsible for pituitary cell lineage determination. We hypothesized that dysregulated PROP1 expression could also be involved in the pathogen
Clinics. Publicado em: 2011
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26. Expressão dos genes relacionados à apoptose, Bcl-2, bax, e caspase-3 nos adenomas hipofisários clinicamente não funcionantes e seu potencial como marcador do comportamento tumoral / Bcl-2, bax and caspase-3 apoptosis related genes expression in nonfunctioning pituitary adenoma and their role as potential markers of tumor behavior
Pituitary adenomas are benign, slow-growing tumors that arise in the sella turcica and account for 10% to 15% of all intracranial tumors. Non-functioning pituitary adenomas (NFPA) account for around one third of all pituitary adenomas. NFPA do not clinically present as hormonal syndromes and are generally diagnosed as macroadenomas due to marked neurological
Publicado em: 2010
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27. Isolated familial somatotropinoma: 11Q13-LOH and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesis
OBJECTIVE: Non-pituitary tumors have been reported in a subset of patients harboring germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene. However, no detailed investigations of non-pituitary tumors of AIP-mutated patients have been reported so far. PATIENTS: We examined a MEN1- and p53-negative mother-daughter pair with acromeg
Clinics. Publicado em: 2010
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28. Análise do gene AIP na acromegalia familial isolada / Analysis of the AIP gene in familial isolated acromegaly
Acromegaly is a rare disfigurating and insidious disease characterized by enlargement of hands, feet and skull bones due to excess of growth hormone (GH) secreted by a pituitary tumor (somatotropinoma). The majority of the cases with acromegaly is sporadic, however it may occur in association with inherited disorders as Multiple Endocrine Neoplasia type 1 (M
Publicado em: 2010
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29. Papel da via lkaros-FGFR4 na evolução pós-cirúrgica dos pacientes com doença de Cushing / Ikaros-FGFR4 pathway: role in the postoperative outcome of Cushings disease
Introduction: The mechanisms involved in the molecular pathogenesis of corticotroph pituitary tumors are complex, heterogeneous and in most cases remain unknown. Changes in the expression of components of Ikaros (Ik) pathway, such as receptor 4 of fibroblast growth factor (FGFR4), have been detected in pituitary tumors including corticotropinomas. Imbalance
Publicado em: 2010
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30. Crotalus durissus terrificus venom as a source of antitumoral agents
The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase patients' survival. Snake venoms are natural sources of bioactive substances with therapeutic potential. The
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2010
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31. Analysis of postoperative findings on dynamic magnetic resonance imaging of patients operated for pituitary tumors by transsfenoidal endonasal approach / Estudo das alterações em exames de ressonância magnética de pacientes em pós-operatório imediato de ressecção de tumores hipofisários por via transesfenoidal
Exames pós-operatórios de cirurgias intracranianas são difíceis de serem interpretados por apresentarem alterações morfológicas que simulam situações patológicas, como edema e tumores residuais. Com o advento de métodos de ressonância intraoperatória essa interpretação ganhou maior importância, pelo risco de re-intervenções desnecessárias.
Publicado em: 2010
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32. Effect of cyhalothrin on Ehrlich tumor growth and macrophage activity in mice
Cyhalothrin, a pyrethroid insecticide, induces stress-like symptoms, increases c-fos immunoreactivity in the paraventricular nucleus of the hypothalamus, and decreases innate immune responses in laboratory animals. Macrophages are key elements in cellular immune responses and operate at the tumor-host interface. This study investigated the relationship among
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-10
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33. Estudo do sistema neuroimunoendócrino na caquexia neoplásica e da resposta ao tratamento com esteróides
The anorexia-cachexia syndrome (ACS), of multifactorial source and complex, is common in chronic diseases, like advanced cancer. Is associated with weight loss and decrease food intake, sometimes causing death. The objective of the present study was to evaluate the influence of neoplastic cachexia over the hypothalamus-pituitary-adrenal axis and immune syste
Publicado em: 2008
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34. Somatostatin analogs in acromegaly: comparison of clinic response, laboratory and tumor volume with expression of somatostatin receptor subtype in somatotroph tumor / Análogos da somatostatina na acromegalia: comparação da resposta clínica, laboratorial e do volume tumoral com a expressão dos subtipos dos receptores de somatostatina no tumor somatotrófico
Este estudo analisa a expressão dos subtipos de receptores da somatostatina (SSTR) em 39 adenomas secretores de GH. Em 19 pacientes acromegálicos, a resposta clínica, laboratorial e radiológica ao análogo da somatostatina (AS) octreotide-LAR foi comparada à expressão dos SSTR. O SSTR mais freqüentemente expresso foi o SSTR5, seguido pelos SSTR3, SSTR
Publicado em: 2008
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35. Adenomas hipofisarios : estudo clinico, morfologico e morfometrico; busca de fatores de prognostico utilizando o metodo imunoistoquimico / Pituitary adenomas : a clinical, morphological and morphometric study : searching for prognostic factors with the immunohistochemical method
Pituitary Adenomas (PA) are an easily identifiable and benign epithelial neoplasia. They are clinically detected through symptoms of an increased or decreased hormone rate and/or alterations of intra-cranial mass. They are classed in accordance with radiological / macroscopical aspects (macro versus microadenoma / invasive versus non-invasive), functional st
Publicado em: 2007
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36. Study of mRNA expression of the receptors for vasopressin (AVPR1B), corticotropin releasing hormone (CRHR1) and GH secretagogues (GHSR-1a) in patients with ACTH-dependent Cushings syndrome: clinical-molecular correlation / Estudo da expressão do receptor da vasopressina (AVPR1B), do receptor do hormônio liberador de corticotrofina (CRHR1) e do receptor dos secretagogos de GH (GHSR-1a) em pacientes portadores de síndrome de Cushing ACTH-dependente: correlação clínico-molecular
INTRODUCTION: The differential diagnosis of ACTH-dependent Cushings syndrome (CS) is one of the major challenges in endocrinology, especially in view of the similar clinical and laboratorial behavior between some carcinoid tumors and Cushings disease (CD). Hence, dynamic tests of ACTH and cortisol release have been carried out with the aim to identify predic
Publicado em: 2006