Phospholipase A2
Mostrando 25-36 de 1268 artigos, teses e dissertações.
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25. Uma orientação diagnóstica para neurodegeneração com acúmulo cerebral de ferro: aspectos clínicos, genéticos e de neuroimagem
RESUMO A neurodegeneração com acúmulo cerebral de ferro (sigla em inglês NBIA) representa um grupo heterogêneo e complexo de doenças neurodegenerativas hereditárias, caracterizada pelo acúmulo cerebral de ferro, especialmente nos núcleos da base. O quadro clínico das NBIAs em geral inclui distúrbios do movimento, particularmente parkinsonismo e di
Arq. Neuro-Psiquiatr.. Publicado em: 2016-07
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26. Anticancer properties of phospholipase A2 fromDaboia siamensis venom on human skin melanoma cells
Abstract Background Phospholipase A2 (PLA2) is a major component of theDaboia siamensis venom, which is able to hydrolyse the membrane of various cells. For this reason, the activity of PLA2was investigated regarding its pharmaceutical properties. This study was conducted to explore the pharmacological properties of a PLA2from Daboia siamensis (dssPLA2) ve
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 08/03/2016
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27. In vitro activity of phospholipase A 2 and of peptides from Crotalus durissus terrificus venom against amastigote and promastigote forms of Leishmania (L.) infantum chagasi
Abstract Background American visceral leishmaniasis is caused by the intracellular parasiteLeishmania (L.) infantum chagasi, and transmitted by the sand fly Lutzomyia longipalpis. Since treatment is based on classical chemotherapeutics with significant side effects, the search for new drugs remains the greatest global challenge. Thus, this in vitro study a
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 22/12/2015
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28. Cytolytic and systemic toxic effects induced by the aqueous extract of the fire coral Millepora alcicornis collected in the Mexican Caribbean and detection of two types of cytolisins
AbstractBackground Millepora alcicornis is a branching hydrocoral common throughout the Caribbean Sea. Like other members of this genus, this species is capable of inducing skin eruptions and blisters with severe pain after contact. In the present study, we investigated the toxicity of theM. alcicornis aqueous extract on several animal models. Considering th
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/10/2015
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29. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A 2 fromBothrops atrox snake venom
Background Snake venoms are complex mixtures of inorganic and organic components, mainly proteins and peptides. Standardization of methods for isolating bioactive molecules from snake venoms is extremely difficult due to the complex and highly variable composition of venoms, which can be influenced by factors such as age and geographic location of the specim
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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30. The role of melatonin in diabetes: therapeutic implications
Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2). It decreases insulin secretion by inhibiting cAMP and cGMP pathways but activates the phospholipaseC/IP3 path
Arch. Endocrinol. Metab.. Publicado em: 28/08/2015
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31. Antibacterial potential of a basic phospholipase A2(VRV-PL-VIIIa) from Daboia russelii pulchella (Russell's viper) venom
Abstract Background: Microbial/bacterial resistance against antibiotics poses a serious threat to public health. Furthermore, the side effects of these antibiotics have stimulated tremendous interest in developing new molecules from diverse organisms as therapeutic agents. This study evaluates the antibacterial potential o
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/08/2015
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32. Pharmacological characterization of venoms from three theraphosid spiders: Poecilotheria regalis, Ceratogyrus darlingi and Brachypelma epicureanum
Abstract Background Tarantulas (Theraphosidae) represent an important source of novel biologically active compounds that target a variety of ion channels and cell receptors in both insects and mammals. In this study, we evaluate and compare the pharmacological activity of venoms from three taxonomically different theraphos
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/08/2015
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33. Reassessing lipid metabolism and its potentialities in the prediction of cardiovascular risk
There are numerous particles, enzymes, and mechanisms in the lipid metabolism that are involved in the genesis of cardiovascular disease (CVD). Given its prevalence in populations and its impact on mortality, it is relevant to review the lipid metabolism as it may potentially provide subsidies to better prediction. This article reviews the importance of trad
Arch. Endocrinol. Metab.. Publicado em: 2015-04
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34. Antimicrobial activity of apitoxin, melittin and phospholipase A2 of honey bee (Apis mellifera) venom against oral pathogens
O presente estudo avaliou pela técnica da Concentração Inibitória Mínima (CIM) o potencial antibacteriano da apitoxina produzido pela abellha Apis melifera frente aos microrganismos causadores da cárie dental. Apitoxina foi avaliada na forma in naturae comercial. A ação antibacteriana dos principais componentes da apitoxina, fosfolipase A2 e melitina
An. Acad. Bras. Ciênc.. Publicado em: 2015-03
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35. In vitro screening and evaluation of antivenom phytochemicals from Azima tetracantha Lam. leaves against Bungarus caeruleus and Vipera russelli
Background : Snakebites are considered a neglected tropical disease that affects thousands of people worldwide. Although antivenom is the only treatment available, it is associated with several side effects. As an alternative, plants have been extensively studied in order to obtain an alternative treatment. In folk medicine, Azima tetracantha Lam. is usual
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 09/05/2014
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36. Comparative analysis of the venom proteome of four important Malaysian snake species
Background Naja kaouthia, Ophiophagus hannah, Bungarus fasciatus and Calloselasma rhodostoma are four venomous snakes indigenous to Malaysia. In the present study, their proteomic profile by two-dimensional gel electrophoresis (2-DE) have been separated and compared. Results The 2-DE of venoms of the four species snake demonstrated complexity and obvious
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 04/03/2014