Phosphate Esters
Mostrando 1-12 de 91 artigos, teses e dissertações.
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1. IMIDAZOL E CATÁLISE: UM PAR PERFEITO
The imidazole (IMZ) ring presents several chemical properties that turns it into a versatile acid-basic/nucleophilic catalyst. The discovery of the biological properties of histidine (amino acid with IMZ ring) instigates the study of this class of compounds. It is found in nature in several enzymes such as chymotrypsin and RNAses due to these properties. Thi
Quím. Nova. Publicado em: 2021-03
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2. Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves
ABSTRACT Melastoma malabathricum L., Melastomaceae, has been traditionally used to relieve diverse pain-related ailments. The objectives of the present study were to determine the antinociceptive activity of methanol extract of M. malabathricum leaves and to elucidate the possible mechanisms of antinociception involved using various rats' models. The extract
Rev. bras. farmacogn.. Publicado em: 2016-10
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3. Antiwear and antioxidant studies of cardanol phosphate ester additives
In the search for new applications and products derived from Cashew Nut Shell Liquid (CNSL), we report herein the synthesis and characterization (GC/MS and ¹H, 13C, and 31P NMR) of four phosphate esters derived from hydrogenated cardanol, including their applications as antiwear additives for diesel (S500) and as antioxidant additives for mineral oils, eval
Braz. J. Chem. Eng.. Publicado em: 2012-09
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4. Synthesis, screening for antiacetylcholinesterase activity and binding mode prediction of a new series of [3-(disubstituted-phosphate)-4,4,4-trifluoro-butyl]-carbamic acid ethyl esters
Uma nova série de nove 3-fosfato-(4,4,4-trifluor-butil)-carbamatos de etila (compostos fosfato-carbamato), foram obtidos através da reação de (4,4,4-trifluor-3-hidroxibut-1-il)-etil carbamatos com oxicloreto de fósforo seguido de adição de álcoois. Os produtos foram caracterizados por espectroscopia de RMN de ¹H, 13C, 31P e 19F, CG-EM e análise ele
Journal of the Brazilian Chemical Society. Publicado em: 2008
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5. Determinação de parabenos em antitranspirantes empregando voltametria sob eletrodo de diamante e cromatografia liquida de alta eficiencia / Determination of parabens in antiperspirants using voltammetry on boron-doped diamond electrodes and high-performance liquid chromatography
Esters of p-hydroxybenzoic acid, as methylparaben (MePa), ethylparaben (EtPa) and propylparaben (PrPa) have been widely used as chemical preservatives in cosmetics, drugs, foods, and others. As these compounds are linked with allergies, dermatitis and estrogenic properties, it is necessary to control the concentration of these substances in the different mat
Publicado em: 2008
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6. Síntese e estudo das interações de 3-(fosfato)- e 3-(fosfonamida)-4,4,4-trifluor-but-1-il-carbamatos de etila com a enzima acetilcolinesterase e síntese de 3-carboxietil- e 3-pirimidin-2-il-2-oxo-6-trifluormetil-[1,2,3]oxatiazinanas / Synthesis and interactions studies of 3-phosphate- and 3-phosphonamide-4,4,4-trifluoro-but-1-yl-carbamic acid ethyl esters with acetylcholinesterase enzyme and synthesis of 3-carboxyethyl- and 3-pyrimidin-2-yl-2-oxo-6-trifluoromethyl-[1,2,3]oxathiazinanes
A series of [3-(phosphate)-4,4,4-trifluoro-but-1-yl]-carbamic acid ethyl ester and [3-(phosphonamide)-4,4,4-trifluoro-but-1-yl]-carbamic acid ethyl ester obtained from the reaction of g-amino alcohols (4,4,4-trifluoro-3-hydroxy-butan-1-yl)-carbamic acid ethyl ester with phosphorus oxychloride in the presence of base and subsequent reaction with alcohols or a
Publicado em: 2007
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7. On the protein tyrosine phosphatases. Phosphate esters intrinsic reactivity and computer simulation of the mechanisms of enzymatic reaction / Sobre as proteínas tirosina-fosfatases. Reatividade intrínseca de ésteres de fosfato e simulação computacional dos mecanismos de reação enzimática
Proteínas tirosina-fosfatases (PTPs) catalisam a hidrólise de fosfotirosina de outras proteínas e, assim, regulam importantes processos bioquímicos. Dois representantes desta família são as fosfatases de dupla especificidade VHR e CDC25B. A primeira etapa de reação catalisada é um ataque nucleofílico da cadeia lateral de uma cisteína sobre o fósf
Publicado em: 2004
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8. A química dos ésteres de fosfato
This work summarizes important aspects of the chemistry of phosphate esters, with special emphasis on: i) advances in the design of enzymatic models for phosphatases; and ii) nerve agents and currently used strategies for detoxification. The physical organic chemical aspects that are responsible by the reactivity of phosphate esters are also discussed.
Química Nova. Publicado em: 2003-10
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9. Estudo da modulação do canal de sodio pela ativação da proteina quinase
Sodium channels are responsible for the generation of cellular electrical activity involved in specific functions, such as cardiac cell contraction for heart beating, or electrical signal transmission performed by nerve cells for the whole body control. Sodium channels are modulated by many cell mechanisms, incIuding phosphorylation(phosphate ion bonding) of
Publicado em: 1994
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10. Hexose-, Inositol-, and Nucleoside Phosphate Esters in Germinating Seeds of Crested Wheatgrass 1
Net synthesis of phosphate esters was measured in crested wheatgrass seeds [Agropyron desertorum (Fisch.) Schult.] to learn what phosphorylating reactions occur in early stages of germination. Phosphate esters were separated on ion exchange columns and identified by cochromatography and chemical analyses. Synthesis of adenosine triphosphate and UDP-hexose wa
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11. A Study on the Acute Toxicity of the Tri-aryl Phosphates Used as Plasticizers
Paralysis in man and the domestic fowl caused by “ToCP” (tri-cresyl phosphate, tri-tolyl phosphate or TTP) is reviewed, and the search for a non-toxic plasticizer derived either from TTP or tri-xylenyl phosphate (tri-dimethylphenyl phosphate or TXP) is described. It had been previously shown that the ortho-tolyl esters are toxic but we found that their r
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12. PHOSPHATE ESTERS IN MYOTONIC HUMAN MUSCLE