Phenylbutazone
Mostrando 1-12 de 54 artigos, teses e dissertações.
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1. Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
ABSTRACT This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a dose of 2, 6.6, or 20 mg/kg; a significant edema-inhibitory activity
Rev. bras. farmacogn.. Publicado em: 2017-04
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2. Evaluation of post-operative pain in equine arthroscopic surgery / Avaliação da dor no pós-operatório de artroscopia em eqüinos
Durante muito tempo a dor nos animais foi subestimada, pensando-se que não sentiam dor ou que seu limiar era alto. As manifestações de dor eram mal interpretadas ou ignoradas, e por este motivo não existia uma justificativa para a prevenção ou tratamento adequado da dor. Existem sinais de dor nos animais que podem passar desapercebidos, como sons e mud
Publicado em: 2008
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3. Estudo histologico e histofotometrico do tecido de granulação de ratos em condições normais e sob ação de drogas antiinflamatorias
This work had the purpose to follow up the synthesis of collagen and glicosaminoglycanas artificially-induced granulation tis sue in rats, since an early phase till the maturation of this tissue. It were also studied the effects of anti inflammatory drugs with different active principIes upon the evolution of granulation tissue, and a comparison wasmadewith
Publicado em: 1980
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4. Double-blind trial of naproxen and phenylbutazone in ankylosing spondylitis.
In a double-blind double-placebo crossover study naproxen (500-750 mg daily) was found to be equivalent to phenylbutazone (400-600 mg daily) in the control of disease activity in 20 patients suffering from ankylosing spondylitis during a two times 5-week trial period. No serious side effects were observed during the trial period. Gastric complaints occurred
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5. A double blind trial to assess the value of alclofenac compared with phenylbutazone in the management of rheumatoid arthritis.
A double-blind cross-over study using a double placebo technique was employed to compare the effectiveness of daily alclofenac 3 g and phenylbutazone 300 mg in rheumatoid arthritis. (2) Thirty-one patients with classical or definite rheumatoid arthritis entered the trial. Twenty-three patients completed the trial; eight patients were withdrawn while on alclo
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6. Stereoselective Interaction of Phenylbutazone with [12C/13C]Warfarin Pseudoracemates in Man
To evaluate the interaction of phenylbutazone with racemic warfarin or R,S-(±)-warfarin in man, S-(−)-warfarin or levowarfarin was synthesized with 13C label in the 2-position of the coumarin nucleus and added to [12C]R(+)-warfarin or dextrowarfarin to form a [12C/13C]pseudoracemate of warfarin. In six normal human subjects, a single oral dose of this “
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7. The effect of oral phenylbutazone on whole blood platelet aggregation in the dog.
Platelet aggregation to collagen, arachidonic acid and adenosine diphosphate was evaluated in six dogs using a whole blood electronic aggregometer. The six dogs were then given phenylbutazone orally according to four different dosage levels and durations of treatment. Aggregation responses were measured at established intervals of time following phenylbutazo
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8. Multicentre trial of naproxen and phenylbutazone in acute gout.
Naproxen 750 mg as a single dose followed by 250 mg three times daily has been compared with phenylbutazone 200 mg four times daily for 48 hours followed by 200 mg three times daily for treatment of acute gout in an open study on 41 patients. The drugs were equally effective with few and relatively mild side effects. Naproxen is a useful alternative agent fo
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9. Comparative Effects of Phenylbutazone, Naproxen and Flunixin Meglumine on Equine Platelet Aggregation and Platelet Factor 3 Availability in vitro
Nonsteroidal anti-inflammatory drugs are commonly used in the treatment of inflammatory conditions, and have potential value in the treatment of thrombotic disease in the horse. This study compares the potency of three nonsteroidal anti-inflammatory drugs phenylbutazone, naproxen (equiproxen) and flunixin meglumine (banamine) with respect to their effects on
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10. Phenylbutazone and chromosomal damage.
Investigation of 44 paired test and control patients, all suffering from rheumatoid arthritis, following exposure to phenylbutazone (PBZ) and/or oxyphenbutazone (OPB), suggests that there is no significant increase in the level of chromosomal damage in lymphocytes. The control subjects comprised two series, one previously exposed to PBZ and/or OPB, but not f
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11. Chromosomal studies in patients taking phenylbutazone.
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12. Intra-articular injection of phenylbutazone in gonarthrosis.