Pharmacokinetic Evaluation
Mostrando 13-24 de 124 artigos, teses e dissertações.
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13. Desenvolvimento, caracterização físico-química e avaliação farmacocinética de nanopartículas auto-organizadas de quitosana / Development, physico-chemical characterization and pharmacokinetic evaluation of self-assembly chitosan nanoparticules
Objectives: Nanoparticles (NP) are useful to modulate the pharmacokinetics (PK) of drugs. The aim of this study was to develop innovative self-assembly nanovesicles (NV) constituted of chitosan and lecithin with isopropyl myristate (IPM) as oil core, able to modify the PK plasma profile of clozapine (CZP) and valproic acid (VPA). Methods: The NV were obtaine
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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14. Pharmacokinetic Properties In Silico Modeling for New Chemical Entities Evaluation. / Modelagem In silico de propriedades farmacocinéticas para a avaliação de candidatos a novos fármacos
The pharmacokinetic (PK) processes of absorption, distribution, metabolism and excretion (ADME), have been identified as one of the major causes of new chemical entities (NCEs) failure in early clinical trials. In silico models are receiving increased attention in recent years from the pharmaceutical industry, which is integrating a paradigm of multiple phar
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2011
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15. Avaliação das concentrações plasmáticas e da farmacocinética da cefuroxima administrada profilaticamente em pacientes submetidos à revascularização do miocárdio / Plasma levels and pharmacokinetics of cefuroxime administered prophylactically for patients undergoing coronary surgery
Background and Objectives: Cardiopulmonary bypass (CPB) can alter the kinetic of drugs, including antibiotics. The aim of this study was evaluation of the CPB influence on the plasma concentrations and pharmacokinetics of cefuroxime and assess whether the dosing regimen 1.5 g dose, followed by 750 mg 6/6h for 24h is adequate for antibiotic prophylaxis. Metho
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/08/2011
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16. Determinação do perfil farmacocinético de anti-inflamatórios não hormonais aplicados à clinica / Determination of the pharmacokinetic profile of the non-steroidal anti-inflammatory drugs related with clinic outcomes
Objective: The present work aims to evaluation the pharmacokinetic profile of the diclofenac-cholestyramine (140mg capsule) and two pharmaceuticals formulations (100mg tablets and 50mg/m oral suspension) of nimesulide in healthy adult subjects related with clinic outcomes in the hepatic enzymes panel and platelet count. Method: The studies were open, randomi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/08/2011
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17. Desenvolvimento e avaliação da atividade e farmacocinética de nanopartículas lipídicas sólidas contendo a associação de quinina e doxiciclina / Development and evaluation of the activity and pharmacokinetics of solid lipid nanoparticles loaded with the association of Quinine and Doxycycline
Malaria is one of the most devastating tropical diseases caused by intracellular protozoan parasites of the genus Plasmodium. More than 3 billion people live in malarial endemic regions. Five species of Plasmodium (falciparum, vivax, ovale, malariae and knowlesi) cause disease in humans and infection with P. falciparum, the most deadly of these parasites, re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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18. Caracterização de nanopartículas contendo insulina em modelos de animais induzidos ao diabetes / Characterization of nanoparticles containing insulin in animal models induced diabetes
Diabetes Mellitus is a disease whose cases have increased due to the bad habits of life of society. Several strategies have been developed for the treatment of diabetes, especially the controlled release of drugs. The erroneous use of insulin as basal treatment of diabetes takes a problem, since the high dose of the drug can lead to severe hypoglycemia. The
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2010
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19. Avaliação farmacocinética da influência de drogas antiepilépticas indutoras enzimáticas na disposição do levetiracetam em pacientes com epilepsia / Pharmacokinetic evaluation on the influence of enzyme inducing antiepileptic drugs on the disposition of levetiracetam in patients with epilepsy
Introdução: pacientes com epilepsia em tratamento com politerapia podem manifestar sinais de efeitos adversos e/ou ineficácia terapêutica decorrentes das possíveis interações entre as diferentes drogas antiepilépticas (DAEs) que compõem o esquema terapêutico. Para contornar esta situação, as DAEs desenvolvidas atualmente apresentam perfil farmaco
Publicado em: 2010
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20. Biodisponibilidade comparativa de duas formulações de losartan em voluntarios humanos sadios apos administração de dose unica / Comparative bioavailability of two losartan formulations in healthy human volunteers after a single dose administration
This dissertation focus in the evaluation of the bioavailability of two formulations of potassium losartan immediate release tablet 50mg (Losartan from Laboratórios Cristália Ltd., Brazil, as a test formulation and Cozaar® from Merck Sharp &Dohme Farmacêutica Ltd., Brazil as a reference formulation). The bioequivalence study was conducted using an open,
Publicado em: 2009
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21. Estudo do metabolismo, quimica e farmacocinetica do principal metabolito da diidroergocristina / Metabolic, chemical and pharmacokinetics of the main diidroergocristine metabolite
Dihydroergocristine (DHEC) is a semi-synthetic drug mainly used for migraine and studied in age-related cognitive impairment. In this study, its major metabolite 8´-hydroxy-dihydroergocristine (8´-OH-DHEC) was produced in incubates of a bovine liver preparation using dihydroergocristine mesylate (DHECM) as substrate. An evaluation of the best enzymatic pre
Publicado em: 2009
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22. Avaliação pré-clínica em roedores do perfil farmacocinético do benzaldeído semicarbazona livre e complexado em ß-ciclodextrina / Preclinical evaluation in rodents of the pharmacokinetic profile of benzaldehyde semicarbazone free and complexed with ß-cyclodextrin
Objetivos: Avaliar a farmacocinética e a distribuição tecidual do benzaldeído semicarbazona livre (BS) e incluso em ß-Ciclodextrinas (BS/ß-CD) após administração de diversas doses por diferentes vias de administração. Metodologia: As concentrações plasmáticas de BS foram quantificadas através de método analítico por CLAE-UV desenvolvido e va
Publicado em: 2009
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23. Evaluation of bioequivalence of conventional tablet and orally disintegrating tablet containing 8 mg ondansetron / Avaliação da bioequivalência entre comprimido convencional e comprimido de desintegração oral contendo 8 mg de ondansetrona
A ondansetrona (1,2,3,9-tetrahidro-9-metil-3-[(2-metil-1H-imidazol-1-il)metil]-4H-carbazol-ona) é o primeiro fármaco da classe dos antagonistas seletivos dos receptores de serotonina 5-HT3. É utilizada na prevenção de náusea e vômito induzidos por agentes quimioterápicos. O objetivo deste estudo foi avaliar a equivalência terapêutica através da an
Publicado em: 2008
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24. Metho of quantification of nucleotides by HPLC-MS/MS and evaluation of the activity of sildenafil analoges in phosphodiesterase / Metodo de quantificação de nucleotideos por HPLC-MS/MS e avaliação da atividade de analogos de sildenafil sobre fosfodiesterase
In the present work a new method for the dosage of the activity of phosphodiesterase was standardized in vitro, for HPLC-MS/MS. This new method obtained to present exactness, precision, sensitivity, and rapidity in the analyses; monitoring the nucleotides (AMP, GMP, cAMP and cGMP). The development of new drug derived from an archetype points with respect to
Publicado em: 2007