Pharmaceutical Formulations
Mostrando 1-12 de 230 artigos, teses e dissertações.
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1. Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
Objective: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. Methods: In a randomized, double-blind, placebo-controlled, parallel-group desi
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Eco-friendly multivariant green analytical technique for the estimation of ketoconazole by UV spectroscopy in bulk and cream formulation
The pharmaceutical industries are focusing on Green Analytical Chemistry principles like miniaturization, eco-friendly solvent usage, waste recycling, and analyst safety for sustainable results. A simple, eco-friendly sensitive and effective extraction and multivariant green analytical method to estimate ketoconazole in bulk and cream formulation were develo
Química Nova. Publicado em: 2022
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3. Graphite-Polyurethane Composite Electrode Modified with Molecularly Imprinted Polymer for Determination of Diclofenac
A molecularly imprinted polymer (MIP) was prepared using the anti-inflammatory diclofenac (DCF) as a template. A non-imprinted polymer (NIP) was also prepared as a control. These MIP and NIP were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET), revealing a higher porosity in the fir
Journal of the Brazilian Chemical Society. Publicado em: 2022
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4. On the Use of a TiO2 Sol-Gel for Horseradish Peroxidase Enzyme Immobilization for Development of an Amperometric Biosensor
The sol-gel technique has drawn considerable attention in the area of biomolecules immobilization by virtue of its intrinsic properties including chemical inertness, thermal stability, and good biocompatibility. The present work reports the development of a bio-sensing methodology which involves the immobilization of horseradish peroxidase enzyme (HRP) on pe
J. Braz. Chem. Soc.. Publicado em: 2021-06
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5. Assessment of the Physicochemical Quality Indicators and Microbiological Effects of Brazilian Ozonized Vegetable Oils
The study of quality indicators in the process of obtaining ozonized vegetable oils is useful for monitoring the ozonation reaction. The Brazilian oils “dendê”, soy, corn, rice and sunflower were studied, all of them were ozonated applying different doses of ozone. Ozonized oils were evaluated by determining the physicochemical indexes of peroxide, acid
J. Braz. Chem. Soc.. Publicado em: 2021-01
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6. Stability Indicating Method for Determination of Benznidazole and Its Degradation Products in Active Pharmaceutical Ingredient
Currently, treatment of Chagas disease is restricted to the use of benznidazole and nifurtimox; however, nifurtimox was temporarily suspended in some countries. Based on the limitations in pharmacological treatments, it is essential to guarantee the quality of benznidazole. Therefore, this work aimed to identify the degradation products of benznidazole and t
J. Braz. Chem. Soc.. Publicado em: 2020-06
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7. Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies
Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its main metabolite). The aim of this formulation study was to
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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8. Square-Wave Voltammetry Determination of Ciprofloxacin in Pharmaceutical Formulations and Milk Using a Reduced Graphene Oxide Sensor
In this paper, a simple, sensitive and precise electroanalytical method was developed using a chemically-reduced graphene-oxide (CRGO)-modified glassy carbon electrode and square wave voltammetry (SWV) for determination of ciprofloxacin in pharmaceutical formulations (tablets) and milk samples. Advantages of this sensor include a potential displacement of 10
J. Braz. Chem. Soc.. Publicado em: 16/09/2019
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9. SYNTHESIS, CHARACTERIZATION AND in vitro CYTOTOXICITY OF Acacia mearnsii PROANTHOCYANIDIN LOADED PLGA MICROPARTICLES
ABSTRACT One of the highlighted areas in the development of new materials is the generation of micro- and nanoparticles as drug carriers which allow the progress in formulations with the ability to release active agents in a controlled way. The proanthocyanidins (PAC) extracted from the bark of the Black Wattle have stood out for their biological activities.
Braz. J. Chem. Eng.. Publicado em: 15/07/2019
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10. Pharmaceutical ethnobotany in the Mahabad (West Azerbaijan) biosphere reserve: ethno-pharmaceutical formulations, nutraceutical uses and quantitative aspects
This study endeavors to overcome the limits of an orally transmitted pharmacopoeia, and tries to utilize the large ethnobotany patrimony of the area to investigate the biological diversity. Thirty-five traditional practitioners from dissimilar ethnic groups including traditional health practitioners (THPs) and indigenous people were interviewed. A total of 3
Braz. J. Pharm. Sci.. Publicado em: 10/07/2019
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11. Development and validation of a quantification method for α-humulene and trans-caryophyllene in Cordia verbenacea by high performance liquid chromatography
ABSTRACT Acheflan® herbal medicine is the first medicine developed and produced in Brazil using Cordia verbenacea DC., Boraginaceae, essential oil as a constituent. C. verbenacea has anti-inflammatory properties, which have been directly related to α-humulene and trans-caryophyllene. Currently, the quantification of α-humulene and trans-caryophyllene in C
Rev. bras. farmacogn.. Publicado em: 27/05/2019
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12. DETERMINAÇÃO DE Al3+, Fe3+ E Cu2+ PRESENTES EM SOMBRAS DE MAQUIAGEM POR ESPECTROFOTOMETRIA UV-Vis: UMA PROPOSTA DE EXPERIMENTO CONTEXTUAL EM NÍVEL SUPERIOR DE ENSINO
Metallic oxides are used in cosmetic shadows formulations in order to highlight the area around the eyes, with different colors. Due to the close proximity to the eye mucosa, these products are a potential source of metal intoxication in human body. Based in this fact, several analytical methods to quantify metals in cosmetic shadows have been proposed in th
Quím. Nova. Publicado em: 02/05/2019