Peptide Hormones
Mostrando 13-24 de 239 artigos, teses e dissertações.
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13. Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite
Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we
Brazilian Journal of Medical and Biological Research. Publicado em: 05/04/2007
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14. Conformational properties of peptide hormones binding to G protein coupled receptors in solution and in the presence of model membranes / Propriedades conformacionais de hormônios peptídicos ligantes de receptores acoplados a proteínas G em solução e em presença de membranas modelo
Os hormônios peptídicos Angiotensina II (Ang II) e bradicinina (BK) ativam transdução de sinal através da ligação a Receptores Acoplados a Proteínas G (GPCR). Este trabalho propõe o estudo de propriedades conformacionais, através de espectroscopia de fluorescência da Ang II e BK e de seus análogos contendo o marcador de spin ácido 2,2,6,6-tetram
Publicado em: 2007
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15. Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin
Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues. Ghrelin is a novel acylated peptide which is produced mainly by the stomach. It is also synthesized in the hypothalamus and is pres
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-08
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16. High expression of human carboxypeptidase M in Pichia pastoris: Purification and partial characterization
Carboxypeptidase M (CPM) is an extracellular glycosylphosphatidyl-inositol-anchored membrane glycoprotein, which removes the C-terminal basic residues, lysine and arginine, from peptides and proteins at neutral pH. CPM plays an important role in the control of peptide hormones and growth factor activity on the cell surface. The present study was carried out
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-02
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17. Caracterização funcional de genes diferencialmente regulados por glicocorticóides e análise do proteoma em linhagem de glioma sensível à hormônios anti-tumorais glicocorticóides / Functional characterization of glucocorticoid differentially regulated genes and proteomic analysis of the anti-tumoral effect of glucocorticoid in a glucocorticoid-sensitive rat glioma cell line
The glucocorticoid (GC) growth suppression response is controlled through cellular cascades in which the transcription of primary response genes regulates the expression and activity of a diverse set of genes including important factors for cell cycle progression. However, the functional connection between the GC-regulated transcriptional events and cell cyc
Publicado em: 2005
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18. Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides
Chronic stimulation of sympathetic nervous activity contributes to the development and maintenance of hypertension, leading to left ventricular hypertrophy (LVH), arrhythmias and cardiac death. Moxonidine, an imidazoline antihypertensive compound that preferentially activates imidazoline receptors in brainstem rostroventrolateral medulla, suppresses sympathe
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-08
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19. Modulation of hormone secretion by functional electrical stimulation of the intact and incompletely dysfunctional dog pancreas
The purpose of the present study was to modulate the secretion of insulin and glucagon in Beagle dogs by stimulation of nerves innervating the intact and partly dysfunctional pancreas. Three 33-electrode spiral cuffs were implanted on the vagus, splanchnic and pancreatic nerves in each of two animals. Partial dysfunction of the pancreas was induced with allo
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-03
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20. Role of estradiol on bovine luteolysis: estradiol stimulates PGF2&alpha througthout P4 receptor activation in the endometrium? / As funções do estradiol no processo da luteólise em bovinos: o estradiol estimula PGF2α através da ativação de receptores de P4 no endométrio?
Estradiol (E2) is essential for triggering luteolysis in ruminants. The low E2 concentrations after follicular ablation prolongs luteolysis instead of E2 injections in late luteal phase stimulate prostaglandin F2α (PGF2α) and luteolysis. The E2 could act in endometrium avoiding progesterone (P4 ) to stimulate PGF 2α secretion. A P4 antagoni
Publicado em: 2004
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21. Efeitos da injeção de moxonidina no controle da ingestão de sódio e regulação cardiovascular.
Deficit of water and sodium in the body is detected by receptors located in different parts of the body. These receptors or hormones signalize to specific areas in the brain that control renal responses and water and sodium intake. Among these areas are: organum vasculosum of the lamina terminalis (OVLT), subfornical organ (SFO), anteroventral third ventricl
Publicado em: 2003
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22. Nitrergic modulation of vasopressin, oxytocin and atrial natriuretic peptide secretion in response to sodium intake and hypertonic blood volume expansion
The central nervous system plays an important role in the control of renal sodium excretion. We present here a brief review of physiologic regulation of hydromineral balance and discuss recent results from our laboratory that focus on the participation of nitrergic, vasopressinergic, and oxytocinergic systems in the regulation of water and sodium excretion u
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-09
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23. The brain decade in debate: VIII. Peptide hormones and behavior: cholecystokinin and prolactin
This article is a transcription of an electronic symposium held on November 28, 2000 in which active researchers were invited by the Brazilian Society of Neuroscience and Behavior (SBNeC) to discuss the advances of the last decade in the peptide field with particular focus on central actions of prolactin and cholecystokinin. The comments in this symposium re
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-11
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24. Clonagem do Receptor de ACTH de células adrenocorticais Y-1 de camundongo e expressão em fibroblastos 3T3 e células de AR-1 para elucidação de vias de transdução de sinal / Cloning of ACTH receptor from mouse Y1 adrenocortical cells and expression in to mouse 3T3 fibroblasts and AR-1 cells for the study of signal transduction pathways.
The adrenocorticotropic hormone, ACTH, regulates both function and proliferation of adrenocortical cells binding to a specific receptor, ACTHR, which belongs to superfamily of GPCR (G-protein coupled receptors). ACTHR was cloned a few years ago, but the molecular mechanisms underlying the mitogenic and anti-mitogenic actions of ACTH remain unknown, whose elu
Publicado em: 2001