P27 C Jun
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Como investigar um resultado de ferritina elevado?
Os casos de hiperferritinemia devem ser inicialmente investigados repetindo-se a dosagem de ferritina, além da dosagem de saturação de transferrina e hemograma com plaquetas. Deve-se investigar se o paciente tem história familiar de sobrecarga de ferro ou cirrose, história de reposição de ferro em excesso ou sobrecarga secundária a transfusões, u
Núcleo de Telessaúde Rio Grande do Sul. Publicado em: 12/06/2023
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2. Como deve ser feita a inibição da lactação?
Métodos não farmacológicos:
– Evitar a sucção e outras formas de estímulo.
– Aplicar compressas frias durante 10 minutos, 4 vezes ao dia.
– Fazer enfaixamento compressivo, com ataduras elásticas por volta de 7 a 10 dias após o parto, com cuidado para não restringir os movimentos respiratórios ou causar desconforto materno
Núcleo de Telessaúde Rio Grande do Sul. Publicado em: 12/06/2023
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3. A phthalide derivative isolated from endophytic fungiPestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells
MP [4-(3′,3′-dimethylallyloxy)-5-methyl-6-methoxyphthalide] was obtained from liquid culture of Pestalotiopsis photiniaeisolated from the Chinese Podocarpaceae plant Podocarpus macrophyllus. MP significantly inhibited the proliferation of HeLa tumor cell lines. After treatment with MP, characteristic apoptotic features such as DNA fragmentation and chrom
Braz J Med Biol Res. Publicado em: 30/07/2013
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4. Comparação imunoistoquímica das expressões das proteínas p27 e c-jun na carcinogênese intra-oral / Immunohistochemical comparison between the p27 and c-jun proteins expression in the oral carcinogenesis
The expression of many cell cycle proteins has been studied in a number of malignant lesions. Among the main ones is the p27, which is encoded by the same name tumor suppressor gene, and it is altered in carcinomas, including oral cancers. Another protein that plays a role in the cell cycle control is the c-jun, which is encoded by a proto-oncogene, and acts
Publicado em: 2009
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5. Clonagem do Receptor de ACTH de células adrenocorticais Y-1 de camundongo e expressão em fibroblastos 3T3 e células de AR-1 para elucidação de vias de transdução de sinal / Cloning of ACTH receptor from mouse Y1 adrenocortical cells and expression in to mouse 3T3 fibroblasts and AR-1 cells for the study of signal transduction pathways.
The adrenocorticotropic hormone, ACTH, regulates both function and proliferation of adrenocortical cells binding to a specific receptor, ACTHR, which belongs to superfamily of GPCR (G-protein coupled receptors). ACTHR was cloned a few years ago, but the molecular mechanisms underlying the mitogenic and anti-mitogenic actions of ACTH remain unknown, whose elu
Publicado em: 2001
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6. Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis
The p27Kip1 protein is a cyclin-dependent kinase inhibitor that blocks cell division in response to antimitogenic cues. p27 expression is reduced in many human cancers, and p27 functions as a tumor suppressor that exhibits haploinsufficiency in mice. Despite the well characterized role of p27 as a cyclin-dependent kinase inhibitor, its mechanism of tumor sup
National Academy of Sciences.
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7. Induction of Id1 and Id3 by Latent Membrane Protein 1 of Epstein-Barr Virus and Regulation of p27/Kip and Cyclin-Dependent Kinase 2 in Rodent Fibroblast Transformation
Latent membrane protein 1 (LMP1), the Epstein-Barr virus oncoprotein, activates NF-κB, phosphatidylinositol 3-kinase, mitogen-activated protein kinase, and c-Jun N-terminal kinase signaling. To determine global transcriptional changes induced by LMP1 in epithelial cells, genomic analysis of C33A cells stably expressing LMP1 was performed. Relatively few gen
American Society for Microbiology.
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8. Analysis of the genes involved in the insulin transmembrane mitogenic signal in Chinese hamster ovary cells, CHO-K1, utilizing insulin-independent mutants.
CHO-K1 cells, wild type (WT), grow in a defined medium with insulin as the only essential hormone. When starved for insulin, these cells accumulate in G0/G1 stage. Insulin binding to its receptor stimulates DNA synthesis and cell division and induces an increase in abundance of mRNA for c-fos, c-jun, Krox-20, Krox-24 (zif/268), fra-1, jun-B, c-myc, and JE. T
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9. 壽Activation of the mitogen-activated protein kinase pathways by heat shock
In addition to inducing new transcriptional activities that lead within a few hours to the accumulation of heat shock proteins (Hsps), heat shock activates within minutes the major signaling transduction pathways involving mitogen-activated protein kinases, extracellular signal–regulated kinase, stress-activated protein kinase 1 (SAPK1)–c-Jun N-terminal
Cell Stress Society International.
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10. Ogt-Dependent X-Chromosome-Linked Protein Glycosylation Is a Requisite Modification in Somatic Cell Function and Embryo Viability
The Ogt gene encodes a glycosyltransferase that links N-acetylglucosamine to serine and threonine residues (O-GlcNAc) on nuclear and cytosolic proteins. Efforts to study a mammalian model of Ogt deficiency have been hindered by the requirement for this X-linked gene in embryonic stem cell viability, necessitating the use of conditional mutagenesis in vivo. W
American Society for Microbiology.
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11. Jab1 antagonizes TGF-β signaling by inducing Smad4 degradation
Tumor suppressor Smad4 is the common signaling effector in the transforming growth factor β (TGF-β) superfamily. Phosphorylated regulatory Smads (R-Smads) interact with Smad4, and the complex translocates into the nucleus to regulate gene transcription. Proper TGF-β signaling requires precise control of Smad functions. Smurfs have been shown to mediate th
Oxford University Press.
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12. Excretion of Human β-Endorphin into Culture Medium by Using Outer Membrane Protein F as a Fusion Partner in Recombinant Escherichia coli
Escherichia coli BL21 strains were found to excrete a large amount of outer membrane protein F (OmpF) into culture medium during high-cell-density cultivation. From this interesting phenomenon, a novel and efficient OmpF fusion system was developed for the excretion of recombinant proteins by E. coli. The ompF gene of E. coli BL21(DE3) was first knocked out
American Society for Microbiology.