Comparação imunoistoquímica das expressões das proteínas p27 e c-jun na carcinogênese intra-oral / Immunohistochemical comparison between the p27 and c-jun proteins expression in the oral carcinogenesis

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The expression of many cell cycle proteins has been studied in a number of malignant lesions. Among the main ones is the p27, which is encoded by the same name tumor suppressor gene, and it is altered in carcinomas, including oral cancers. Another protein that plays a role in the cell cycle control is the c-jun, which is encoded by a proto-oncogene, and acts as a positive regulator of the cell cycle, through other signaling pathways. The present study aimed to compare the immunohistochemical expression of p27 and c-jun proteins, using the streptavidinbiotin method, in 45 cases of epithelial dysplasia, classified in different degrees (mild, moderate and intense), and 20 cases of oral squamous cells carcinoma, in an attempt to elucidate the role and the relationship between these proteins. It was observed a decrease of p27 levels and a substantial increase of c-jun in cases with the highest degrees of epithelial dysplasia. The statistical analysis showed a significant inverse correlation between p27 and c-jun expressions. These results suggest these proteins alterations as an important event in the carcinogenic process. p27, c-jun, Immunohistochemistry, Squamous cells carcinoma, Epithelial dysplasia

ASSUNTO(S)

displasia epitelial carcinoma epidermóide imunoistoquímica p27 c-jun carcinoma epidermóide p27 c-jun imunoistoquímica displasia epitelial

ACESSO AO ARTIGO

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