P2 Purinergic Receptors
Mostrando 13-24 de 59 artigos, teses e dissertações.
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13. Estudo do Segmento Consenso Adjacente ao Domínio TM2 e parte do Domínio TM2 do Receptor P2X7: Dinâmica Molecular e Atividade de Canal Iônico. / Study of the segment adjacent consensus to domain TM2 and part of domain TM2 of receiver P2X7: molecular dynamics and activity of ionic canal.
The purinergic receptor P2X7 (P2X7R) is a membrane protein which forms channels in the presence of extracellular ATP. Once opened, the channels allow the transport of cations through the cellular membrane, being expressed preferentially in immune cells. Among all purinergic receptors, P2X7R has distinct characteristics from other P2X (P2XR) members. For exam
Publicado em: 2007
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14. Estudo das bases mecanísticas da diferenciação neuronal mediada pela atividade de Ca2+ através dos receptores purinérgicos e colinérgicos / Study of mechanistic bases of neuronal differentiation mediated by Ca2+ activity through purinergic and cholinergic receptors
Muitos subtipos de receptores são ativados pelo mesmo ligante, mas estão acoplados a diferentes mensageiros secundários podendo produzir sinalização divergente em uma célula, enquanto receptores ativados por diferentes ligantes, mas que compartilham o mesmo mensageiro secundário, podem produzir sinalização convergente. Para examinar as bases mecaní
Publicado em: 2007
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15. Purinergic central pathways involved in the muscle blood flow regulation during alerting defense behaviours. / Vias centrais purinérgicas envolvidas na regulação do fluxo sangüíneo muscular durante os comportamentos de alerta e defesa
The electrical stimulation (ES) of the hypothalamus in the rat produces a well- defined pattern of cardiovascular adjustments including hypertension, tachycardia and skeletal muscle vasodilation. These hemodynamic responses can also be observed in natural conditions during fight and/or flight behaviors. However the neural pathways and possible neurotransmitt
Publicado em: 2006
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16. Estudo das propriedades biofísicas e farmacológicas do poro associado ao receptors P2X7 e poros de características similares. / Study of the biophysical and pharmacological properties of the pore associated with receiver P2X7 and pores of similar characteristics.
The P2X7 receptor (EC50= ~100μM) induces cell membrane permeabilization to molecules up to 900 Da when activated by high ATP concentrations. So far, the correlation between the opening of low conductance cationic channel (8 pS) formed after stimulation with low ATP concentrations (EC50= ~1 μM) and the opening of P2X7 related pore is unclear. To dat
Publicado em: 2006
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17. Activation of a P2Y4-like purinoceptor triggers an increase in cytosolic [Ca2+] in the red blood cells of the lizard Ameiva ameiva (Squamata, Teiidae)
An increasing number of pathophysiological roles for purinoceptors are emerging, some of which have therapeutic potential. Erythrocytes are an important source of purines, which can be released under physiological and physiopathological conditions, acting on purinergic receptors associated with the same cell or with neighboring cells. Few studies have been c
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-01
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18. Tetrodotoxin-sensitive Na+ channels and muscarinic and purinergic receptors identified in human erythroid progenitor cells and red blood cell ghosts
This article concerns the identification of different types of voltage-gated Na+ channels and of muscarinic and purinergic receptors that are expressed in human erythroid precursor cells and red cell ghosts. We analyzed, by RT-PCR, RNA that was extracted from purified and synchronously growing human erythroid progenitor cells, differentiating from erythrobla
National Academy of Sciences.
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19. The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role.
We have investigated responses of human monocyte/macrophage cells to extracellular ATP (ATPe). Freshly isolated peripheral blood monocytes showed responses linked to P2Y but not P2Z purinergic receptors; however, during in vitro macrophage differentiation, these cells also exhibited responses suggestive of the presence of the membrane-permeabilizing P2Z rece
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20. P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.
Somatic sensation requires the conversion of physical stimuli into the depolarization of distal nerve endings. A single cRNA derived from sensory neurons renders Xenopus laevis oocytes mechanosensitive and is found to encode a P2Y1 purinergic receptor. P2Y1 mRNA is concentrated in large-fiber dorsal root ganglion neurons. In contrast, P2X3 mRNA is localized
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21. Potential role of purinergic signaling in lithium-induced nephrogenic diabetes insipidus
Lithium (Li)-induced nephrogenic diabetes insipidus (NDI) has been attributed to the increased production of renal prostaglandin (PG)E2. Previously we reported that extracellular nucleotides (ATP/UTP), acting through P2y2 receptor in rat medullary collecting duct (mCD), produce and release PGE2. Hence we hypothesized that increased production of PGE2 in Li-i
American Physiological Society.
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22. P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells.
To develop a new approach to the treatment of advanced, hormone-refractory prostate cancer, the signal transductions regulating the growth of human androgen-independent prostate carcinoma cell lines were studied. Agonist-stimulated Ca2+ mobilization, a critical regulatory event in other secretory cell types, was studied as a means of identifying previously u
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23. Paracrine purinergic signaling determines lung endothelial nitric oxide production
Although the vascular bed is a major source of nitric oxide (NO) production, factors regulating the production remain unclear. We considered the role played by paracrine signaling. Determinations by fluorescence microscopy in isolated, blood-perfused rat and mouse lungs revealed that a brief lung expansion enhanced cytosolic Ca2+ (Ca2+cyt) oscillations in al
American Physiological Society.
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24. P2X7 receptors control 2-arachidonoylglycerol production by microglial cells
Endogenous cannabinoid ligands (endocannabinoids) produced by neurons, astrocytes, and microglial cells activate cannabinoid receptors, the molecular target for marijuana's bioactive ingredient Δ9-tetrahydrocannabinol. The molecular mechanism underlying the production of the most abundant endocannabinoid, 2-arachidonoylglycerol (2-AG), is unclear. A prevale
National Academy of Sciences.