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Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Mutações na região aminoterminal do gene col1a2 e a manifestação da osteogênese imperfeita
A Osteogênese Imperfeita (OI) é uma doença genética associada a alterações na molécula do colágeno tipo I, sendo caracterizada clinicamente por fragilidade e deformidade ósseas. A maioria dos relatos de OI são alterações autossômicas dominantes nos genes COL1A1 e COL1A2, codificadores da molécula do colágeno tipo I. Também há relatos de caso
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2011
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2. Identification of the murine coronavirus p28 cleavage site.
Mouse hepatitis virus strain A59 encodes a papain-like cysteine proteinase (PLP-1) that, during translation of ORF1a, cleaves p28 from the amino terminus of the growing polypeptide chain. In order to determine the amino acid sequences surrounding the p28 cleavage site, the first 4.6 kb of murine hepatitis virus strain A59 ORF1a was expressed in a cell-free t
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3. Characterization of a second cleavage site and demonstration of activity in trans by the papain-like proteinase of the murine coronavirus mouse hepatitis virus strain A59.
The 21.7-kb replicase locus of mouse hepatitis virus strain A59 (MHV-A59) encodes several putative functional domains, including three proteinase domains. Encoded closest to the 5' terminus of this locus is the first papain-like proteinase (PLP-1) (S. C. Baker et al., J. Virol. 67:6056-6063, 1993; H.-J. Lee et al., Virology 180:567-582, 1991). This cysteine
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4. Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications
OPN (osteopontin) is an integrin-binding highly phosphorylated glycoprotein, recognized as a key molecule in a multitude of biological processes such as bone mineralization, cancer metastasis, cell-mediated immune response, inflammation and cell survival. A significant regulation of OPN function is mediated through PTM (post-translational modification). Usin
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