Oxazolone
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. Efeito da fisalina e, isolada da Physalis angulata, em modelos de dermatite de contato induzida por tpa e oxazolona em camundongos / The effects of physalin e, isolated from Physalis angulata, on tpa and oxazolone induced contact dermatitis in mice
The physalin E (PHY E), isolated from the aerial parts of Physalis angulata (Solanaceae), was assessed in models of contact dermatitis induced by 13-acetate-12-o-tetradecanoyl-phorbol (TPA) and oxazolone (OXA) in mice. The irritant contact dermatitis was induced by acute topical administration of TPA (2,5 mg/ear) and evaluated after 4h. The PHY E topically a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 01/12/2009
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2. Efeito dos terpenos Ãcidos centipÃdico e lactona do Ãcido hawtriwaico em modelos de dermatite de contato induzida por TPA e oxazolona em camundongos / The effects of terpens centipedic acid and lactone of hawtriwaic acid on tpa and oxazolone induced contact dermatitis in mice
Os terpenos Ãcido centipÃdico e lactona do Ãcido hawtiwaico (LAH), isolados dos capÃtulos florais de Egletes viscosa Less, popularmente conhecida como macela ou macela da terra, foram avaliados em modelos de dermatite de contato irritativa induzida pelo 13-acetato-12-o-tetradecanoil-forbol (TPA) e de dermatite de contato alÃrgica induzida por oxazolona
Publicado em: 2008
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3. In vitro DNA synthesis opposite oxazolone and repair of this DNA damage using modified oligonucleotides
Emphasis was placed in this work on the assessment of biological features of 2,2,4-triaminooxazolone, a major one-electron and ·OH-mediated oxidation product of guanine. For this purpose, two oligonucleotides that contain a unique oxazolone residue were synthesized. Herein we report the mutagenic potential of oxazolone during in vitro DNA synthesis and its
Oxford University Press.
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4. Reduction of contact sensitivity reactions to oxazolone in mite-infested mice.
Oxazolone-sensitized mite-infested (SWR-M) and mite-free (SWR-J) mice were challenged with oxazolone on the skin of the neck and shoulder. The migration of radioactively labeled cells to the site of contact sensitivity reaction to oxazolone was significantly less in SWR-M than in SWR-J mice. Serum obtained from SWR-M mice suppressed the extravasation of cell
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5. Depression of contact sensitivity by enhancement of suppressor cell activity in Pseudomonas aeruginosa-injected mice.
Heat-killed Pseudomonas aeruginosa depresses contact sensitivity to oxazolone in C56BL/6 mice. The draining lymph nodes and spleens of mice exhibiting an impaired reactivity to oxazolone contain a cell population capable of depressing the response to oxazolone of recipients sensitized immediately before cell transfer. The suppressive activity of these cells
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6. Depression of contact sensitivity by Pseudomonas aeruginosa-induced suppressor cells which affect the induction phase of immune response.
The cellular basis of depression of contact sensitivity to oxazolone in mice injected with Pseudomonas aeruginosa was studied. Cells from draining lymph nodes of mice sensitized with oxazolone 18 h previously were able to induce contact sensitivity to normal mice when administered in their footpads. In contrast, cells from draining lymph nodes of P. aerugino
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7. Contact sensitivity responses in mice infected with Trypanosoma cruzi.
Mechanisms of depression of contact sensitivity responses in C57BL/10 mice infected with Trypanosoma cruzi were studied. Cellular involvement during sensitization with oxazolone was investigated in mice acutely infected with T. cruzi. Contact sensitivity was not expressed in mice during the latter stages of the acute infection. Spleen cells from sensitized,
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8. T suppressor cells as well as anti-hapten and anti-idiotype B lymphocytes regulate contact sensitivity to oxazolone in mice injected with purified protein derivative from Mycobacterium tuberculosis.
Purified protein derivative from Mycobacterium tuberculosis inhibits contact sensitivity to oxazolone in mice when given intravenously 24 to 72 h before the antigen. Transfer experiments showed that various types of suppressor cells occurred in the lymph nodes draining the site of sensitization: (i) anti-oxazolone idiotype + B lymphocytes, found at day 3 aft
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9. Depression of contact sensitivity and enhancement of antibody response in Pseudomonas aeruginosa-infected mice.
The effect of Pseudomonas aeruginosa infection on contact sensitivity to 2-phenyl-4-ethoximethylene-oxazolone (oxazolone) and on antibody response to sheep erythrocytes, horse erythrocytes, and Escherichia coli 0111:B4 lipopolysacharide was investigated in outbred C57BL/6 mice. Injection of 0.5 and 0.2 median lethal doses significantly depressed contact sens
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10. Photooxidation of d(TpG) by riboflavin and methylene blue. Isolation and characterization of thymidylyl-(3',5')-2-amino-5-[(2-deoxy-beta-D- erythro-pentofuranosyl)amino]-4H-imidazol-4-one and its primary decomposition product thymidylyl-(3',5')-2,2-diamino-4-[(2-deoxy-beta-D- erythro-pentofuranosyl)amino]-5(2H)-oxazolone.
The major initial product of riboflavin- and methylene blue-mediated photosensitization of 2'-deoxyguanosine (dG) in oxygen-saturated aqueous solution has previously been identified as 2-amino-5-[(2-deoxy-beta-D-erythro-pentofuranosyl)amino] 4H-imidazol-4-one (dlz). At room temperature in aqueous solution dlz decomposes quantitatively to 2,2-diamino-4-[(2-de
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11. Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells
By screening 720 natural compounds in a standard 2-way allogeneic mixed leukocyte reaction assay, we identified a potent immunosuppressive capacity of crassin acetate (CRA), a coral-derived cembrane diterpenoid. CRA efficiently inhibited allogeneic mixed leukocyte reaction as well as antigen-specific activation of CD4 T cells by bone marrow–derived dendrit
American Society of Hematology.
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12. N-(fluorenyl-9-methoxycarbonyl) amino acids, a class of antiinflammatory agents with a different mechanism of action.
Several members of a series of N-(fluorenyl-9-methoxycarbonyl) amino acids were found to possess a broad spectrum of antiinflammatory activity. The compounds were active against oxazolone dermatitis in mice and adjuvant arthritis in rats, models in which activated T lymphocytes are implicated. The compounds also inhibited T-lymphocyte activation in vitro, as