Oxazolone
Mostrando 13-24 de 26 artigos, teses e dissertações.
-
13. Effect of antithymocyte serum on the course of chlamydial genital infection in female guinea pigs.
The treatment of female guinea pigs, infected in the genital tract with the chlamydial agent of guinea pig inclusion conjunctivitis, with rabbit anti-guinea pig thymocyte serum extended the course of the infection by 20 to 30 days. The rabbit anti-guinea pig thymocyte serum was shown to suppress delayed hypersensitivity responses to the guinea pig inclusion
-
14. Conformational isomerism and the diversity of antibodies.
The fact that one cell encodes a single antibody sequence does not necessarily mean that the resulting antibody folds into a single structure, although this is a common assumption. Here we challenge this view and suggest that many antibodies do not have a single conformation at the combining site. The basis for this proposal comes from the kinetic analysis o
-
15. Immunodepression by Rowson-Parr virus in mice: effect of Rowson-Parr virus and Friend leukemia complex infections on contact sensitivity in susceptible and resistant mice.
Contact sensitivity to 2-phenyl-4-ethoxymethilene oxazolone, as a probe for cell-mediated immunity, was investigated in susceptible BALB/c and resistant C57BL/6 mice after infection with Friend leukemia complex (FLC) or with Rowson-Parr virus (RPV). In BALB/c mice, FLC depressed contact sensitivity when given before primary sensitization but had no effect on
-
16. Isolation and partial characterization of an antigen-specific T-cell factor associated with the suppression of delayed type hypersensitivity.
Antigen-specific factors associated with immunosuppressive activity, released by cultured T cells from mice tolerant to the haptens trinitrophenyl, dinitrophenyl and oxazolone, were purified by hapten affinity chromatography. Their binding specificity for antigens paralleled their immunoregulatory activity. Like some immunoglobulin molecules, these factors h
-
17. Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with a specific monoclonal antibody
Inflammatory destruction of insulin-producing β cells in the pancreatic islets is the hallmark of insulin-dependent diabetes mellitus, a spontaneous autoimmune disease of non-obese diabetic mice resembling human juvenile (type I) diabetes. Histochemical analysis of diabetic pancreata revealed that mononuclear cells infiltrating the islets and causing autoim
The National Academy of Sciences.
-
18. Pineal control of aging: effect of melatonin and pineal grafting on aging mice.
Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB/c females from 23.8 to 28.1 months and preserves aspects of their youthful state. Similar results were seen in New Zealand Black females beginning at 5 months and C57BL/6 males beginning at 19 months. As melatonin is p
-
19. Heparin’s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
Heparin has been used clinically as an anticoagulant and antithrombotic agent for over 60 years. Here we show that the potent anti-inflammatory property of heparin results primarily from blockade of P-selectin and L-selectin. Unfractionated heparin and chemically modified analogs were tested as inhibitors of selectin binding to immobilized sialyl LewisX and
American Society for Clinical Investigation.
-
20. Basophils in tuberculin and "Jones-Mote" delayed reactions of humans.
Jones-Mote reactions are delayed, erythematous, and mildly indurated cutaneous reactions originally described in humans sensitized by skin injection of heterologous proteins. Similar reactions in guinea pigs contain many basophils and are called cutaneous basophil hypersensitivity. In contrast, guinea pigs immunized with mycobacterial adjuvants have classica
-
21. Anti-T-cell idiotype activity in serum of mice injected with syngeneic hapten-specific T-cell lines.
T cells able to mediate specific delayed type hypersensitivity (DH) in mice in response to the haptens azobenzenearsonate (ABA), oxazolone (OX), and picryl chloride have been grown in continuous cultures. They were tested for their ability to react with the hapten in vitro and to induce anti-idiotype antibody in syngeneic mice. Incubation in vitro with OX-gl
-
22. Disruption of T helper 2-immune responses in Epstein–Barr virus-induced gene 3-deficient mice
Epstein–Barr virus-induced gene 3 (EBI3) is a widely expressed IL-12p40-related protein that associates as a heterodimer with either IL-12p35 or an IL-12p35 homologue, p28, to create a new cytokine (IL-27). To define the function of EBI3 in vivo, we generated knockout mice in which the ebi3 gene was targeted by homologous recombination. EBI3−/− mice ex
National Academy of Sciences.
-
23. Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse
In contrast to the immunosuppressive potential of UVB (280–320 nm) radiation in experimental animals and humans, UVA (320–400 nm) radiation at environmentally relevant doses appears to be immunologically inert. However, such exposure to UVA radiation has been observed unexpectedly to induce resistance to UVB-induced immunosuppression in mice, by a mechan
The National Academy of Sciences.
-
24. Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites
Antibodies to phosphatidylcholine (PtC), a common constituent of mammalian and bacterial cell membranes, represent a large proportion of the natural antibody repertoire in mice. Previous studies of several mouse strains (e.g., C57BL/6) have shown that anti-PtC antibodies are mainly encoded by the VH11 and VH12 immunoglobulin heavy chain variable region gene
The National Academy of Sciences.