Oral Solid Dosage Forms
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of th
Matéria (Rio J.). Publicado em: 06/12/2018
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2. Prednisone raw material characterization and formulation development
ABSTRACT Solid dosage forms for oral use, particularly tablets, are the most highly used dosage forms in therapy because they are easily administered, have high productivity and relatively low cost and provide a more stable drug to form a semi-solid net. Numerous parameters influence the quality of the final dosage form. In this study, the dissolution profil
Braz. J. Pharm. Sci.. Publicado em: 08/01/2018
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3. Assessing Drug-Excipient Interactions in the Formulation of Isoniazid Tablets
A suitable and efficient high-performance liquid chromatography (HPLC) method was developed for the simultaneous determination of tuberculostatic isoniazid and its related impurities, isonicotinic acid and isonicotinamide, in oral solid dosage forms. We studied the influence on chromatographic separation of mobile phase parameters, such as pH, ion pairing an
J. Braz. Chem. Soc.. Publicado em: 2016-05
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4. Applications of USP apparatus 3 in assessing the in vitro release of solid oral dosage forms
USP aparato 3 (cilindros recíprocos) é um equipamento bastante versátil para a avaliação das características de liberação
in vitro de formas farmacêuticas sólidas orais, pois permite que o produto seja submetido a diferentes meios de dissolução e condições de agitação, em um único ensaio. Neste trabalho, são apresentadosBraz. J. Pharm. Sci.. Publicado em: 2015-06
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5. Preparation and characterization of solid oral dosage forms containing soy isoflavones
Soy isoflavones have been extensively used for menopausal symptoms and prevention of hormone-related cancer, osteoporosis and cardiovascular diseases. Commercially available forms of isoflavones include supplements, capsules and tablets. However, the non-standardization of soy isoflavones extracts and different dissolution profiles of these solid dosage form
Rev. bras. farmacogn.. Publicado em: 01/02/2013
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6. Avaliação dos critérios de isenção de estudos de bioequivalência in vivo para medicamentos orais em forma farmacêutica sólida de liberação imediata / Evaluation of the criteria for waiving immediate release solid oral dosage forms of in vivo bioequivalence studies
Com a nova lei dos genéricos instituída no Brasil, as indústrias que quiserem fabricá-los deverão comprovar a intercambialidade destes com os medicamentos de referência através de estudos de bioequivalência. Visando reduzir a necessidade dos mesmos por serem onerosos e exporem voluntários sadios aos testes, a Agência Nacional de Vigilância Sanitá
Publicado em: 2010
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7. Microbial quality control of phytomedicines oral solid dosage forms / Contaminação microbiana em medicamentos fitoterápicos sob a forma sólida
84 samples of phytotherapic products of oral solid dosage forms (capsules, tablets and powders) containing 17 different crude drugs and produced by 20 laboratories, marketed in drugstores, herborists and supermarkets at são Paulo-Brazil were analysed with regard to legal marketing requirements, only 15 samples were in accordance. A complete lack of quality
Publicado em: 1992
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8. Evaluation of microcrystalline cellulose prepared from sisal fibers as a tablet excipient: A technical note
The above data demonstrated that MCC derived from sisal fibers could be an industrially feasible alternative for currently used MCCs as diluent and disintegrant for both immediate-release as well as sustained-release oral solid dosage forms.
Springer-Verlag.
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9. Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating
The aim of the present study was to prepare surfactant-free pseudolatexes of various methacrylic acid copolymers. These aqueous colloidal dispersions of polymeric materials for oral administration are intended for film coating of solid dosage forms or for direct manufacturing of manoparticles. Nanoparticulate dispersions were produced by an emulsification-di
Springer-Verlag.
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10. Development of prednisone: Polyethylene glycol 6000 fast-release tablets from solid dispersions: Solid-state characterization, dissolution behavior, and formulation parameters
The aim of the current study was to design oral fast-release polymeric tablets of prednisone and to optimize the drug dissolution profile by modifying the carrier concentration. Solid dispersions were prepared by the solvent evaporation method at different drug:polymer ratios (wt/wt). The physical state and drug:carrier interactions were analyzed by X-ray di
Springer-Verlag.