Opioid System
Mostrando 25-36 de 97 artigos, teses e dissertações.
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25. Antinociceptive properties in mice of a lectin isolated from the marine alga Amansia multifida Lamouroux
The antinociceptive effects of a lectin (LEC) isolated from the marine alga Amansia multifida were determined in Swiss mice. The LEC (1, 5, and 10 mg/kg) inhibited acetic acid-induced abdominal writhings in a dose-dependent manner after intraperitoneal or oral administration. A partial but significant inhibition of writhings was observed after the combinatio
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-01
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26. The influence of stress on nociception induced in temporomandibular joint / A influencia do estresse sobre a nocicepção induzida na articulação temporomandibular
Recent studies have investigated he role of psychological factor in temporomandibular disorders (TMD). However, the mechanisms responsible for nociceptive changes induced by stress are not established. Thus, the aim of this study was to evaluate the effect of acute, sub-chronic and chronic stress on nociception induced by formalin injection in rats? temporom
Publicado em: 2006
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27. ATIVIDADE ANTINOCICEPTIVA DO ÁCIDO MIRSINÓICO B / ANTINOCICEPTIVE ACTIVITY OF MIRSINOIC B ACID
Mirsinoic B Acid (MBA) is a prenilate benzoic acid isolated from Rapanea sp. Various studies have shown that compounds of this type have antifungal, molluscicidal and antiparasitic activity. The objective of this study was to evaluate the role of MBA in the pain process, and the possible antinociceptive mechanisms involved, using some in vivo pharmacological
Publicado em: 2006
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28. Envolvimento de receptores opióides µ1 e das redes neurais do colículo inferior na analgesia pós-ictal / Involvement of the µ1-opioid receptor-mediated system and inferior colliculus in the post-ictal analgesia
A antinocicepção é descrita como redução na capacidade de perceber a dor, sendo importante componente para o organismo, quando este está envolvido em situações de emergência. Muitos neurotransmissores e seus receptores estão envolvidos nas diversas formas de analgesia, como por exemplo, monoaminas, acetilcolina e opióides endógenos. A analgesia p
Publicado em: 2005
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29. ESTUDO FARMACOLÓGICO DA VITEX AGNUS-CASTUS L (AÇÃO ANTINOCICEPTIVA E TOXICIDADE AGUDA DO EXTRATO AQUOSO)
Since ancient times men have been using plants as food, and also for medicine preparation, for its necessity to cure diseases or alleviate pains. Innumerable scientific studies have been carried out aiming to validate popular information about the use of medicinal plants. The importance of this study is real for the following reasons: pain is one of the most
Publicado em: 2005
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30. Envolvimento de receptores opióides e serotoninérgicos nos processos antinociceptivos induzidos por substância doce / Involvement of opioid and serotonergic receptors in antinociceptives process induced by sweet substance
Rationale: Sweet substance-induced antinociception has been widely studied, and the investigation of the neurotransmitters involved in the antinociceptive process is an important way for understanding the involvement of neural system controlling this kind of antinociception. Objective: The aim of this study is to investigate the involvement of opioid and ser
Publicado em: 2004
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31. Antinociceptive activity of Hypericum caprifoliatum and Hypericum polyanthemum (Guttiferae)
The aim of the present study was to assess the analgesic activity of the aerial parts of two Hypericum species native to Southern Brazil, H. caprifoliatum and H. polyanthemum. The antinociceptive effect of the H. polyanthemum cyclohexane extract (POL; 180 mg/kg) and of the H. caprifoliatum methanol (MET) and cyclohexane (CH) extracts (90 mg/kg) was evaluated
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
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32. Antinociceptive activity of sulfated carbohydrates from the red algae Bryothamnion seaforthii (Turner) Kütz. and B. triquetrum (S.G. Gmel.) M. Howe
We report the antinociceptive activity, determined by the writhing, formalin and hot-plate tests in mice, of crude (F0/60), lectin and carbohydrate fractions isolated by ammonium sulfate precipitation (0 to 60%) from Bryothamnion seaforthii and B. triquetrum, species of red algae. Not only fraction F0/60 but also lectins from both species significantly inhib
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-06
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33. Endogenous opiate analgesia induced by tonic immobility in guinea pigs
A function of the endogenous analgesic system is to prevent recuperative behaviors generated by tissue damage, thus preventing the emission of species-specific defensive behaviors. Activation of intrinsic nociception is fundamental for the maintenance of the behavioral strategy adopted. Tonic immobility (TI) is an inborn defensive behavior characterized by a
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-02
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34. Atividade analgesica e antiulcerogenica de quatro extratos de diferentes polaridades obtidos a partir das cascas de Quassia amara L
Quassia amara L., is a small tree 2-6 m in height, which occur in northern Brazil, Venezuela, Surinam, Colombia, Panamá and Guiana; in Brazil, this species is cultivated from the border with Guiana to the state of Maranhão. The bark wood of this plant is reputed in traditional medicine as having antimicrobial, antianemic and antimalarial activities, as wel
Publicado em: 2001
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35. Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism
There is increasing evidence supporting a link between the endogenous opioid system and excessive alcohol consumption. Acute or light alcohol consumption stimulates the release of opioid peptides in brain regions that are associated with reward and reinforcement and that mediate, at least in part, the reinforcing effects of ethanol. However, chronic heavy al
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36. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines.
Using specific ligands, we find that lung cancer cell lines of diverse histologic types express multiple, high-affinity (Kd = 10(-9)-10(-10) M) membrane receptors for mu, delta, and kappa opioid agonists and for nicotine and alpha-bungarotoxin. These receptors are biologically active because cAMP levels decreased in lung cancer cells after opioid and nicotin