Oncogenic Viruses
Mostrando 1-12 de 213 artigos, teses e dissertações.
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1. Interação de oncoproteínas virais E6 e E7 de HPV16/18 com alvos celulares potenciais para o desenvolvimento de estratégias terapêuticas. / Interaction of E6 and E7 viral oncoproteins of HPV16/18 with potential cellular targets to the development of therapeutic strategies.
O potencial oncogênico do papilomavírus humano (HPV) baseia-se na capacidade das oncoproteínas virais E6 e E7 alterarem o ciclo celular, levando à imortalização e malignidade das células. O importante papel das oncoproteínas na progressão tumoral e na interação com inúmeros alvos celulares tem relevância em estudos para o desenvolvimento de vaci
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/11/2012
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2. "Prevalência da infecção pelo Papilomavírus Humano (HPV) em homens soropositivos para HIV e homens parceiros de mulheres com infecção pelo HPV" / Human papillomavirus (HPV) prevalence in seropositive men for HIV and men partners of women infected by HPV
O Papilomavírus humano (HPV) é provavelmente o agente mais prevalente das doenças sexualmente transmissíveis do trato genital.Este estudo foi realizado para comparar as prevalências de HPV nos 144 raspados penianos de homens HIV positivos e negativos.Utilizou PCR PGMY09/11 e hidridização em pontos. A prevalência de HPV nos indivíduos HIV positivo fo
Publicado em: 2006
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3. At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses.
Recombinants of oncogenic and nononcogenic avian leukosis viruses were tested for their oncogenic potential in chickens. The results indicate that at least two regions of the viral genome determine the oncogenic potential of these viruses. The first region contains sequences that control viral mRNA synthesis. These sequences determine the potential of a viru
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4. Facts and Theories on Viruses Causing Cancer and Leukemia
It is possible to explain the familial incidence of cancer developing in several members of the same family tree, within the same as well as in successive generations, by an assumption that tumors and leukemia are caused by oncogenic viruses transmitted in a latent form from one generation to another in many animal species, presumably also in man. The term �
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5. Antigenic and Morphological Similarities of Progressive Pneumonia Virus, a Recently Isolated “Slow Virus” of Sheep, to Visna and Maedi Viruses
Progressive pneumonia virus, the causative agent of a slow, pulmonary disease of Montana sheep, was shown to be antigenically related to two other slow viruses of sheep, visna and maedi. Electron microscopic examination of infected cells revealed that the virus matures by a budding process and that the budding particles as well as the mature, extracellular v
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6. Concentration of Oncogenic Herpesviruses by Methyl Alcohol Precipitation
Oncogenic herpesviruses, like many other viruses, can be concentrated effectively from large volumes of culture fluids by precipitation with methanol with good recovery of infectivity.
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7. Type-specific antigenic determinants on the major external glycoprotein of high- and low-oncogenic murine mammary tumor viruses.
We recently showed that the 52,000-dalton external glycoprotein (gp52) of the highly oncogenic mouse mammary tumor viruses (MMTVs) of RIII, GR, and C3H mice contains both type- and group-specific antigenic determinants. This was demonstrated by using a competition radioimmunoassay with 125I-externally labeled virions and antisera to the gp52 of MMTV from RII
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8. A structural change of the plasma membrane induced by oncogenic viruses: quantitative studies with the freeze-fracture technique.
In BHK21 hamster cells a significant increase in density of intramembranous particles occurs in freeze-fractured plasma membranes after transformation by hamster sarcoma and polyoma viruses. A similar change has been observed in chick embryo cells infected and transformed by a mutant of Rous sarcoma virus thermosensitive for transformation, at both permissiv
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9. Acquisition of oncogenicity by endogenous mouse type C viruses: effects of variations in env and gag genes.
Several dual-tropic isolates derived from the thymuses of preleukemic or leukemic AKR mice and a more recrnt group of viruses generated by in vitro or in vivo passage of a poorly infectious endogenous virus of C3H mouse cells have been shown to be highly oncogenic. By analysis of the immunological properties of their gag gene-coded structural proteins, each
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10. Herpesvirus saimiri strains from three DNA subgroups have different oncogenic potentials in New Zealand white rabbits.
Herpesvirus saimiri is a primate tumor virus that induces acute T-cell lymphomas in New World monkeys. Strains of this virus have been previously classified into three groups on the basis of extreme DNA variability of the rightmost region of unique L-DNA. To compare the oncogenic potentials of various strains, we inoculated New Zealand White rabbits with vir
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11. Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host.
Chronic infection with hepatitis B viruses (hepadnaviruses) is a major cause of hepatocellular carcinoma (HCC), but the incubation time varies from 1 to 2 years to several decades in different host species infected with indigenous viruses. To discern the influence of viral and host factors on the kinetics of induction of HCC, we exploited the recent observat
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12. Sequence comparison in the crossover region of an oncogenic avian retrovirus recombinant and its nononcogenic parent: genetic regions that control growth rate and oncogenic potential.
NTRE 7 is an avian retrovirus recombinant of the endogenous nononcogenic Rous-associated virus-0 (RAV-0) and the oncogenic, exogenous, transformation-defective (td) Prague strain of Rous sarcoma virus B (td-PrRSV-B). Oligonucleotide mapping had shown that the recombinant virus is indistinguishable from its RAV-0 parent except for the 3'-end sequences, which