Oligoclonal Bands
Mostrando 1-12 de 52 artigos, teses e dissertações.
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1. For survival, the emergence of oligoclonal bands after multiple myeloma treatment is less important than achieving complete remission
Abstract Background: The emergence of oligoclonal bands, proteins differing from those originally identified at diagnosis, has been reported in multiple myeloma patients after high-dose chemotherapy followed by autologous stem cell transplantation and after successful conventional chemotherapy. The clinical relevance of oligoclonal bands remains unclear, bu
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-12
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2. Oligoclonal bands in the cerebrospinal fluid and increased brain atrophy in early stages of relapsing-remitting multiple sclerosis
OBJECTIVE: To determine if the presence of oligoclonal bands (OB) at early stages of multiple sclerosis was associated with higher brain atrophy, when compared with patients without OB. METHODS: Relapsing-remitting multiple sclerosis (RRMS) patients with less than two years of disease onset and OB detection in cerebrospinal fluid (CSF) were included. SIENAX
Arquivos de Neuro-Psiquiatria. Publicado em: 2012-08
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3. Estudo de bandas oligoclonais restritas ao líquido cefalorraquidiano em pacientes com esclerose múltipla na cidade de São Paulo / Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo
Introduction: The diagnosis of multiple sclerosis (MS) although clinical, is rounded out with the results of magnetic resonance imaging, in addition to an analysis of the cerebrospinal fluid (CSF), which form a set of indispensible tools. The presence of oligoclonal bands (OCB) in the CSF is used in the study and for the diagnosis of MS. The frequency of OCB
Publicado em: 2009
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4. Esclerose multipla : mediadores da resposta inflamatoria associadas a ressonancia magnetica quantitativa / Quantitative MRI and CSF inflammatory mediators in a sample of brazilian multiple sclerosis population : a prospective study
Quantitative MRI and CSF inflammatory mediators in a sample of brazilian multiple sclerosis population: a prospective study. Multiple sclerosis (MS) is referred to as a chronic inflammatory, demyelinating, and neurodegenerative disorder of the central nervous system (CNS), with a highly variable clinical course and prognosis. This is a prospective study to i
Publicado em: 2009
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5. Esclerose multipla : correlação clinica, liquido cefalorraquiano e neuroimagem
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) of unknown aetiology, which first manifestations occur in adolescence or in young adulthood, after multifocal demyelination caused by an autoimmune and inflammatory process. The clinical evolutive sequence can take the relapsing-remitting, secondarily progressive and primary pro
Publicado em: 2003
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6. Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS
Oligoclonal IgM bands restricted to cerebrospinal fluid are an unfavorable prognostic marker in MS, the most common demyelinating disease of the CNS. We have attempted to identify the B cell subpopulation responsible for oligoclonal IgM secretion and the specificity of these bands. In addition, we explored the relationship between specificity and disease evo
American Society for Clinical Investigation.
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7. Identification of virus-specific oligoclonal bands in subacute sclerosing panencephalitis by immunofixation after isoelectric focusing and peroxidase staining.
We developed a sensitive peroxidase staining procedure to identify oligoclonal band specificity in subacute sclerosing panencephalitis by subjecting serum and cerebrospinal fluid to isoelectric focusing and immunofixation with measles virus. The gel was washed and stained with horseradish peroxidase-conjugated goat antihuman immunoglobulin G. The samples sho
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8. Precipitation of measles virus proteins by immunoglobulin G fractions containing groups of oligoclonal bands isolated from sera of patients with subacute sclerosing panencephalitis.
Groups of oligoclonal immunoglobulin G (IgG) bands were isolated from sera of patients with subacute sclerosing panencephalitis by employing preparative isoelectric focusing. Six IgG fractions containing two to three oligoclonal bands with different isoelectric points were used to precipitate the proteins from Vero cells infected with measles virus. The resu
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9. Oligoclonal banding in the cerebrospinal fluid of patients with postencephalitic Parkinsonism.
Two recent sporadic cases of progressive Parkinsonism after encephalitis are described. Both patients had two oligoclonal protein bands in their CSF. These bands were not present in patients with idiopathic Parkinson's disease and might, therefore, be useful for diagnostic purposes, particularly when the history of encephalitis is uncertain.
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10. A comparison of cellulose acetate immunofixation with polyacrylamide gel electrophoresis for the detection of oligoclonal bands in unconcentrated cerebrospinal fluid.
Two methods of electrophoresis for the detection of oligoclonal bands in unconcentrated CSF were compared. A sample of 98 routine CSFs yielded 18 positives by polyacrylamide gel electrophoresis (PAGE) while cellulose acetate electrophoresis with immunofixation (CAIF) gave 13 positives (72% of the PAGE findings). Despite the loss of sensitivity the cellulose
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11. The significance of serum oligoclonal bands in neurological diseases.
The presence of oligoclonal bands (OCBs) of immunoglobulin G (IgG) in CSF provides evidence for the occurrence of a humoral immune response, but it is not always appreciated that the oligoclonal IgG may have originated in the serum. To determine the diagnostic significance of serum OCBs 146 patients with serum OCBs were identified among 1874 patients with su
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12. Oligoclonal banding of IgG in CSF, blood-brain barrier function, and MRI findings in patients with sarcoidosis, systemic lupus erythematosus, and Behçet's disease involving the nervous system.
A retrospective study of CSF and serum analysis from a total of 43 patients with sarcoidosis, 20 with systemic lupus erythematosus, and 12 with Behçet's disease with neurological involvement found local synthesis of oligoclonal IgG using isoelectric focusing and immunoblotting in 51%, 25%, and 8% respectively at some stage in their disease. Blood-brain barr