Olfactory Response
Mostrando 25-36 de 120 artigos, teses e dissertações.
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25. acj6: a gene affecting olfactory physiology and behavior in Drosophila.
Mutations affecting olfactory behavior provide material for use in molecular studies of olfaction in Drosophila melanogaster. Using the electroantennogram (EAG), a measure of antennal physiology, we have found an adult antennal defect in the olfactory behavioral mutant abnormal chemosensory jump 6 (acj6). The acj6 EAG defect was mapped to a single locus and
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26. Selective imaging of presynaptic activity in the mouse olfactory bulb shows concentration and structure dependence of odor responses in identified glomeruli
More chemicals can be smelled than there are olfactory receptors for them, necessitating a combinatorial representation by somewhat broadly tuned receptors. To understand the perception of odor quality and concentration, it is essential to establish the nature of the receptor repertoires that are activated by particular odorants at particular concentrations.
The National Academy of Sciences.
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27. Rapid application and removal of second messengers to cyclic nucleotide-gated channels from olfactory epithelium.
The last step in the second-messenger cascade mediating vertebrate olfactory transduction is the direct opening of a nonspecific cation channel by cAMP. The kinetic properties of this interaction are critical in determining the time course of the sensory response. To analyze these properties, excised inside-out membrane patches containing either the native c
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28. Expression Patterns of Odorant Receptors and Response Properties of Olfactory Sensory Neurons in Aged Mice
The sense of smell deteriorates in normal aging, but the underling mechanisms are still elusive. Here we investigated age-related alterations in expression patterns of odorant receptor (OR) genes and functional properties of olfactory sensory neurons (OSNs)—2 critical factors that define the odor detection threshold in the olfactory epithelium. Using in si
Oxford University Press.
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29. Analysis of synaptic potentials in mitral cells in the isolated turtle olfactory bulb.
1. The synaptic responses of mitral cells have been analysed in intracellular recordings from the isolated olfactory bulb of the turtle. 2. The response of a mitral cell to a single volley in the lateral olfactory tract consisted of and antidromic impulse and a complex hyperpolarizing potential that had the properties of an inhibitory post-synaptic potential
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30. Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons.
Olfactory marker protein (OMP) is an abundant, phylogentically conserved, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons. To address its function, we generated OMP-deficient mice by gene targeting in embryonic stem cells. We report that these OMP-null mice are compromised in their ability to respond t
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31. Optical Imaging of Postsynaptic Odor Representation in the Glomerular Layer of the Mouse Olfactory Bulb
Olfactory glomeruli are the loci where the first odor-representation map emerges. The glomerular layer comprises exquisite local synaptic circuits for the processing of olfactory coding patterns immediately after their emergence. To understand how an odor map is transferred from afferent terminals to postsynaptic dendrites, it is essential to directly monito
American Physiological Society.
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32. Analysis of a long-duration inhibitory potential in mitral cells in the isolated turtle olfactory bulb.
1. An inhibitory potential of long duration has been analysed in intracellular recordings from mitral cells in the isolated turtle olfactory bulb preparation. 2. A single volley in the olfactory nerves or lateral olfactory tract elicited synaptic inhibition in mitral cells, followed by a long-lasting hyperpolarization of the cell. This slow potential has bee
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33. Side-Specificity of Olfactory Learning in the Honeybee: Generalization between Odors and Sides
Honeybees (Apis mellifera) can be trained to associate an odor stimulus with a sucrose reward. The neural structures involved in the detection and integration of olfactory stimuli are represented bilaterally in the brain. Little is known about the respective roles of the two sides of the brain in olfactory learning. Does each side learn independently of the
Cold Spring Harbor Laboratory Press.
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34. Learning modulates the ensemble representations for odors in primary olfactory networks
Recent evidence suggests that odor-driven responses in the insect antennal lobe (AL) can be modified by associative and nonassociative processes, as has been shown in the vertebrate olfactory bulb. However, the specific network changes that occur in response to olfactory learning remain unknown. To characterize changes in AL network activity during learning,
National Academy of Sciences.
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35. Olfactory dysfunction in Parkinson's disease.
OBJECTIVE: To evaluate olfactory function in Parkinson's disease. METHODS: A standardised odour identification test was used, together with an evoked potential assessment with hydrogen sulphide. In addition, histological analysis was performed on the olfactory bulbs of cadavers who died from Parkinson's disease. RESULTS: Over 70% of patients studied (71 of 9
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36. N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.
N-Acetylaspartylglutamate, an endogenous brain peptide that binds with high affinity to a subpopulation of glutamate-binding sites in rat brain, is excitatory on rat piriform cortex pyramidal cells studied in a perfused brain slice. Both the monosynaptic excitation of the pyramidal cells elicited by stimulation of the lateral olfactory tract and the response