Nude Mice
Mostrando 13-24 de 932 artigos, teses e dissertações.
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13. Evaluation of 99mTc-HYNIC-βAla-Bombesin(7-14) as an agent for pancreas tumor detection in mice
Pancreatic adenocarcinoma is important in oncology because of its high mortality rate. Deaths may be avoided if an early diagnosis could be achieved. Several types of tumors overexpress gastrin-releasing peptide receptors (GRPr), including pancreatic cancer cells. Thus, a radiolabeled peptide derivative of gastrin-releasing peptide (GRP) may be useful as a s
Braz J Med Biol Res. Publicado em: 19/05/2015
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14. Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible
Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects
J. Appl. Oral Sci.. Publicado em: 2015-02
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15. DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth
DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity, which results in hypermethylation of DNA. The main objectives of this study were to determine whether DNA h
Braz J Med Biol Res. Publicado em: 30/09/2014
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16. Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cells
Protein phosphatase magnesium/manganese-dependent 1D (PPM1D) is a p53-induced phosphatase that functions as a negative regulator of stress response pathways and has oncogenic properties. However, the functional role ofPPM1D in bladder cancer (BC) remains largely unknown. In the present study, lentivirus vectors carrying small hairpin RNA (shRNA) targeting PP
Braz J Med Biol Res. Publicado em: 23/09/2014
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17. CIAPIN1 gene silencing enhances chemosensitivity in a drug-resistant animal model in vivo
Overexpression of cytokine-induced apoptosis inhibitor 1 (CIAPIN1) contributes to multidrug resistance (MDR) in breast cancer. This study aimed to evaluate the potential of CIAPIN1 gene silencing by RNA interference (RNAi) as a treatment for drug-resistant breast cancer and to investigate the effect of CIAPIN1 on the drug resistance of breast cancer in vivo.
Braz J Med Biol Res. Publicado em: 21/03/2014
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18. Primary tumorectomy promotes angiogenesis and pulmonary metastasis in osteosarcoma-bearing nude mice
PURPOSE: To investigate the effect of primary tumorectomy on angiogenesis and pulmonary metastasis in osteosarcoma-bearing nude mice. METHODS: Osteosarcoma was introduced to nude mice via subcutaneous injection of MG-63 cells. One hundred and eighty osteosarcoma-bearing mice were used equally in 3 parallel experiments. The effect of tumorectomy (TR) on the e
Acta Cir. Bras.. Publicado em: 2013-03
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19. Synergistic growth inhibition by sorafenib and vitamin K2 in human hepatocellular carcinoma cells
OBJECTIVE: Sorafenib is an oral multikinase inhibitor that has been proven effective as a single-agent therapy in hepatocellular carcinoma, and there is a strong rationale for investigating its use in combination with other agents. Vitamin K2 is nearly non-toxic to humans and has been shown to inhibit the growth of hepatocellular carcinoma. In this study, we
Clinics. Publicado em: 2012-09
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20. A conjugate of an anti-midkine single-chain variable fragment to doxorubicin inhibits tumor growth
Doxorubicin (DOX) was conjugated to a single-chain variable fragment (scFv) against human midkine (MK), and the conjugate (scFv-DOX) was used to target the chemotherapeutic agent to a mouse solid tumor model in which the tumor cells expressed high levels of human MK. The His-tagged recombinant scFv was expressed in bacteria, purified by metal affinity chroma
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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21. STGC3 inhibits xenograft tumor growth of nasopharyngeal carcinoma cells by altering the expression of proteins associated with apoptosis
STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in nude mice injected subcutaneously with Tet/pTRE-STGC3/CNE2 ce
Genetics and Molecular Biology. Publicado em: 02/02/2012
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22. BC047440 antisense eukaryotic expression vectors inhibited HepG2 cell proliferation and suppressed xenograft tumorigenicity
The biological functions of the BC047440 gene highly expressed by hepatocellular carcinoma (HCC) are unknown. The objective of this study was to reconstruct antisense eukaryotic expression vectors of the gene for inhibiting HepG2 cell proliferation and suppressing their xenograft tumorigenicity. The full-length BC047440 cDNA was cloned from human primary HCC
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-02
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23. Morphofunctional evaluation of human skin preserved in glycerol and exposed to gamma radiation: a study in athymic mice / Avaliação morfofuncional de pele humana conservada em glicerol e submetida à radiação gama: estudo em camundongos atímicos
Extensas lesões na pele expõem o organismo a uma série de agentes agressores, dificultando a reparação espontânea da pele e muitas vezes levando o paciente a óbito. Nesse caso, se não houver áreas doadoras de autoenxertos, pode se utilizar aloenxertos. Neste tipo de enxerto, os tecidos são processados em Bancos de Tecidos, onde se pode empregar a r
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2011
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24. Inhibition of STAT3 by RNA interference suppresses angiogenesis in colorectal carcinoma
In order to investigate signal transduction and activation of transcription 3 (STAT3) signaling on angiogenesis in colorectal carcinoma (CRC) after inhibiting STAT3 expression, we constructed the HT-29-shSTAT3 cell line by lentivirus-mediated RNAi. Cell growth was assessed with MTT and the cell cycle distribution by flow cytometry. CRC nude mouse models were
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-12